19-year-old shot dead by JDU leader's son for overtaking his SUV

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, Mar 18: BJP MLC Lahar Singh Siroya on Wednesday wrote a letter to Karnataka Chief Minister B S Yeddyurappa, urging him to allow half-an-hour daily discussion in the State Assembly and Council to take stock and review preparation of the government to contain the spread of coronavirus.

"Since the entire world including India is facing an emergency-like situation, it is appropriate for lawmakers to discuss the matter in the legislature. I would like to request you to allow the matter to be discussed every day in the upper house," said Siroya in his letter to the Chief Minister.

He said discussion and suggestions on the issue can help the government to improve the surveillance activities.

He said members of the Assembly can bring realistic information from their districts and present the same before the House.

Stressing that Bengaluru is a global hub of software and electronic industries, Siroya said: "We need to step up surveillance on the improvement of the international community. So, we have to discuss in detail and devise a robust strategy to contain the spread of the disease."

He asserted there is a possibility of people using social media to mislead public.

"lf the government discusses and debates the issue besides making announcements if any, there will be no scope for social media to mislead the public. Media is doing a good job in educating people. So, I would like to request you to involve the media and select NGOs to sensitise people and bring in the preventive mechanism of self-quarantine more effectively," he said.

Two more people have tested positive for COVID-19 in Karnataka on Wednesday, taking the tally of infected persons in the state to 13, Health Minister B Sriramulu said.

A total of 147 positive cases of coronavirus have been reported in India so far, as per the Union Ministry of Health and Family Welfare. The deadly virus has claimed three lives in the country, the first one was reported from Karnataka.

Bengaluru, May 28: As many as 115 new coronavirus cases were reported in Karnataka on Thursday taking the infection count to 2,533, Karnataka Minister S Suresh said.

The total coronavirus cases include 834 discharges, 1,650 active cases, 47 deaths so far due to the disease and two deaths due non-COVID causes, Suresh Kumar, who is minister for primary and secondary education, said during the daily COVID-19 briefing.

According to him, 29 cases were reported in Udupi on Thursday, followed by 24 in Dakshina Kannada district, 13 in Hassan, 12 in Bidar, nine in Bengaluru Urban, seven in Yadagiri, six in Chitradurga, five in Kalaburagi, four in Haveri, three in Chikkamagaluru, two in Vijayapura and one in Raichur.

The minister said among the new cases, 95 are inter-state passengers and two international passengers.

According to the health department, 84 infected people have returned from Maharashtra and eight from Tamil Nadu.

Among those discharged today, 13 are in Davangere, 12 in Dakshina Kannada, nine each in Yadagiri and Vijayapura, five in Gadag, three in Belagavi, one each in Mysuru and Bagalkote.

Two are severe acute respiratory infection cases.

There were, however, no coronavirus related deaths in the state today, the minister said.

Kumar said the government has issued another circular making changes in the quarantine rules.

"A person who has completed seven days of institutional quarantine and is asymptomatic can be permitted for home quarantine without a COVID test, subject to undergoing medical check-up," the minister said.

According to the circular, all elderly people of above 60 years of age and those with comorbidities such as diabetes, hypertension, asthma, heart ailment and renal diseases, are required to be clinically evaluated diligently prior to shifting them to home quarantine.

Such people will be under mandatory home quarantine for seven days, the circular read.