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Kalaburgi, May 27: Karnataka's Kalaburgi district recorded a maximum temperature of 44 degrees Celsius on Tuesday, as per information provided by the India Meteorological Department (IMD).

In light of the increasing mercury levels, people here were seen consuming sugarcane juice and cold drinks to beat the heat. Animals and birds could also be seen searching for water for relief from the scorching sun.

Locals of the area requested the district administration to take necessary actions such as spraying water on roads, in order to bring down the temperatures.

"We are facing huge heat waves in this district from the past two days, and even the temperature is around 44 to 45 degrees on a daily basis. So, it is a very alarming situation in Kalaburgi. When we move around the city, we are unable to find water and fresh fruit juice, and even if fresh juice is available, we are afraid of getting infected by COVID-19," said one local.

"If we carry cold water, it gets warm within half an hour, and gets unfit for drinking, and it is tough for us. I request the district administration to look into this matter and do the needful such as spraying water on the roads, etc. for slightest relief," he added.

We, the undersigned express our solidarity with Dr Zafarul Islam Khan, renowned scholar, journalist and presently Chairman of the Delhi Minorities Commission.

We strongly condemn the continued media trial and targeting of Dr Zafarul Islam Khan for his Facebook post thanking Kuwait for expressing solidarity with Indian Muslims. In his Facebook post, he mentioned the appalling deterioration of human rights of Indian Muslims who have been targeted by Hindutva bigots. A few politicians with ulterior motives and news channel anchors known for spreading bigotry and Islamophobia have mischievously sought to misinterpret his statement and ridiculously label him as anti-Hindu and anti-India.

He has only reiterated what many citizens of India, public figures, international institutions, various European governments, the United States of America and United Nations human rights mechanisms have repeatedly underlined their concern at the increasing human rights abuse and violations of religious minorities in India.

Dr Zafarul Islam Khan is a man of integrity. He is a scholar who is known to stand up for constitutional freedoms and values.

His work as the Chairman of Delhi Minorities Commission has been warmly applauded by human rights activists and NGOs across different faiths. His timely interventions on problems of minorities in Delhi have made him a respectable figure among not only Muslims but Sikh, Christians, Jains and Parsis. He is a humanist in the truest sense of the word.

The hateful propaganda against Dr Khan is one more illustration as how certain Indians fail to differentiate between Hinduism, a religion and Hindutva which is a supremacist political ideology.

Dr Zafarul Islam Khan is a leading Indian intellectual whose niche area is Islamic studies and Arab world. He enjoys great respect in the Arab and Muslim world for his understanding and knowledge. He is an alumni of the esteemed Jamia Al-Azhar and Manchester University.

Dr Khan is known for taking bold public positions. He was the first Muslim scholar in the world who denounced ISIL, which later became IS or ISIS. He issued a statement opposing the barbaric crimes of ISIL (IS or ISIS) and Boko Haram against minorities. He takes strong stands against extremism of all sorts. That makes him a prominent critic of RSS.

Dr Khan is a scholar ambassador and earned international prestige for the India. Any attack and targeting of him, is actually an insult to Indian constitution and ethos.

We demand the appropriate authorities of the Government of India take strong legal action against those who are distorting Dr Khan’s Facebook post, and spreading vicious false propaganda against him.

Signed by:

Swami Agnivesh

Mohammad Adeeb
Arun Kumar (Prof)

Zafar Jung

Kamal Faruqui

Annie Namala

Kavita Krishnan

Subhash Gatade

Jawed Naqvi

Indu Pratap Singh

Avinash Kumar

Iftikhar Gilani

Anil Chamadia

Xavier Dias

Denzil Fernandes (Dr)

Irfan Engineer

Faisal Khan

John Dayal (Dr)

Mujtaba Farooque

Ravi Nair

Abubakr Sabbaq (Adv)

Gopal Menon

Bilal Khan

Ashok Choudhury

Jaffer Latief Najar

Mujahid Nafis

Aseem Sundan

Poojan Sahil

Ankur Otto

Mariya Salim

Tanweer Alam

Juned Khan

E M Abdul Rahiman

Aditi Dutta

Devika Prasad

Ameeque Jamei

Suhaib Ansari

Gurminder Singh

A C Michael

Neelima Sharma

Aftab Alam (Dr)

Dhruva Narayan

Syed Saif Ur Rahman

Tanweer Fazal (Dr)

Thouseef Madikeri (Dr)

N.D. Jayaprakash

Salahuddin Ansari

Satyajeet Nambiar

Suhail KK

Abu Sufiyan

Sujata Madhok

Tariq Khan

Violin Mathew Benjamin

Shamsul Islam (Prof)

Sreedhar Ramamurthi

Mohd. Shahid (Prof)

Anand Vivek Taneja (Dr)

Kush Kumar Singh (Dr)

Mangla Verma

Vipul Kumar

Waquar Hasan

Braham Prakash

Abdul Rashid Agwan

Fawaz Shaheen

Guman Singh

Mohammed Hafeez Ulla

Kp Sasi

Mushfique Raza Khan

Partha S Banerjee

Gautam Majumdar

S.Q. Masood

Aiman J Khan

M. K. Faizy

Tasleem Rehmani (Dr)

Mohammed Shafi

Lenin Raghuvanshi (Dr)

Malik Motasim Khan

Kripal Singh Mandloi

Labeed Shafi

Qamar Intakhab

Raees Ahmed Siddiqui

Laeeq Ahmed Khan

Anthony Arulraj

Sadiq Zafar

Biju Gopidasan

George Pulikuthiyil

Mohd Abdullah

Mohd Sorab Hussain

Mukunda Kattel

Sandeep Pendse

Paul Newman

Ovais Sultan Khan

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer.