Amulya Leona’s family home in Chikkamagaluru attacked by alleged BJP supporters

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, Mar 6: The Karnataka government has directed school authorities to grant leave to students and staff suffering from cold or fever in the light of renewed coronavirus (COVID -19) fears.

"If any student, teacher of staff is suffering from respiratory infections, they should be granted leave. They should be allowed to come back to school only after confirming from the doctor that they are cured. In case of a student or staff staying at hostels developing any symptoms, they should be kept in a separate room," said the government circular.

Aiming at containing the spread of coronavirus, Sriramulu said, "We have formed 1,680 isolation wards in private hospitals. Chief Minister B.S. Yediyurappa has apprised Prime Minister Narendra Modi and Union Health Minister of the situation."

However, the Health Minister said no positive case has been recorded till now in the state.

"Tests are also being conducting on passengers arriving in Karnataka and all precautionary measures are being taken," said Sriramulu about the 40,000 people thermal screened at the Kempegowda International Airport (KIA) in the city. Major private hospitals in the city have geared up to treat suspected cases.

Five Karnataka districts bordering Kerala -- Dakshina Kannada, Kodagu, Udupi, Chamarajanagar and Mysuru -- continue to be under surveillance after three positive coronavirus cases were reported in Kerala

The deadly virus has killed a total of 2,912 people in mainland China till Saturday, bringing the global death toll to more than 3,000, authorities said on Monday.

The Karnataka Health and Family Welfare Department is observing 461 people under home quarantine even as no positive coronavirus case has been reported from the state, an official said on Thursday.

"We are observing 461 people for Coronavirus symptoms at their residences, however, no positive case has emerged from Karnataka," said state Health Department's Joint Director, Communicable Diseases, Prakash Kumar.

The five people under isolated observation at Rajiv Gandhi Institute of Chest Diseases continue to be so on Thursday as well. As many as 273 samples sent from the state for coronavirus testing reported negative.

In Karnataka, 68,717 passengers have been thermal-screened for the virus until now at Kempegowda International Airport in the city and Mangluru International Airport.

Another 5,103 passengers were also checked for the virus at Karwar and Mangluru seaports.

On Thursday, 16 people completed the mandatory 28-day observation period while a total of 225 people also underwent the same.

Karnataka is screening all international passengers and the state health department met the private sector hospitals to take stock of recent developments.

Kannur, Jun 21: Customs sleuths on Sunday seized 432 grams of gold worth around Rs 20 lakh from a passenger who arrived at Kannur International Airport from Dubai in Fly Dubai flight, scheduled under Vande Bharat Mission.

Customs Assistant Commissioner E Vikas-led team seized the smuggled gold from the passenger Usman of Malappuram district and detained him, sources said.

The seized gold was kept in his inner-wear.