Antibiotic may may kill dangerous skin cancer cells, says study

Agencies
October 7, 2018

London, Oct 7: An existing antibiotic may selectively kill dangerous cells within melanoma, the deadliest type of skin cancer, a study claims.

The research, published in the journal Cell Chemical Biology, found the drug, called nifuroxazide, showed promise for complementing existing melanoma therapies.

Researchers at the University of Edinburgh in the UK tested the drug’s effect on melanoma cells in mice and samples from human tumours.

They caution more research is needed to determine if it will be effective in people.

Within a single tumour there can be variation in the properties of the cells, with some more dangerous than others, in terms of their potential to support growth or become resistant to drug treatment.

Many of the more dangerous cells in melanoma tumours produce a lot of an enzyme called aldehyde dehydrogenase 1 (ALDH1).

Current research into therapies has focused on blocking ALDH1, but in this study the researchers went a step further and aimed to selectively kill cells producing high ALDH1.

They used the drug nifuroxazide, an antibiotic, that is activated by the enzyme ALDH1, which means that it only becomes toxic once it is inside cells producing ALDH1.

Using samples of human melanomas implanted in mice the researchers showed that the nifuroxazide therapy killed the tumour cells that produced a lot of ALDH1, without significant toxicity to other cells in the body.

The researchers hope that the strategy may complement existing melanoma treatments, called BRAF and MEK inhibitors.

Currently, some people’s tumours develop resistance to BRAF and MEK inhibitors and the researchers found that some of these resistant tumours were high in ALDH1.

In the lab, the researchers simulated this by treating cancer cells lines with BRAF and MEK inhibitors, which increased the number of cells with high levels of ALDH1 and made the cells especially sensitive to nifuroxazide treatment.

“We’ve shown this antibiotic that’s used mostly to target intestinal bacteria can also target and kill cancer cells high in the enzyme ALDH1,” said Liz Patton from the University of Edinburgh.

“It’s great that this antibiotic is approved for use in humans, but it wasn’t designed as a cancer drug, so we still need to find out if it’s safe and effective for cancer in humans — for example, can it get to the cancer in the body and are the doses needed safe,” said Patton.

“We may need to take the concept for how this antibiotic works and re-design it to make it better at killing cancer,” Patton said.

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News Network
February 22,2020

Feb 22: The subjective feeling of well-being experienced by many people with the practice of meditation is associated with specific changes in the brain, according to a study which may lead to better clinical recommendations of the practice.

The study, published in the journal Brain and Cognition, examined the effects of the technique known as Transcendental Meditation (TM), which consists of the silent repetition of a meaningless sound.

In the study, the researchers from the IMT School for Advanced Studies Lucca in Italy, enrolled 34 healthy young volunteers and divided them in two groups.

They said the first group practised TM 40 minutes per day in two sessions of 20 minutes each, one in the morning and the other in the evening.

The second group, the scientists said, did not change its daily routine.

Using questionnaires, they also measured the anxiety and stress levels of all the participants at the beginning of the study, as well as the subjects' ability to manage stressful situations.

According to the researchers, the participants were also subjected to a functional magnetic resonance imaging (fMRI) brain scan, in order to measure the organ's activity at rest, and changes in the excitation among different cerebral areas.

They repeated the tests after three months, at the end of the study.

According to the study, the levels of anxiety and stress perceived by the subjects who followed the meditation program were significantly reduced in comparison with those of the volunteers who did not practice TM.

"Magnetic resonance imaging also shows that the reduction of anxiety levels is associated with specific changes in the connectivity between different cerebral areas, such as precuneus, left parietal lobe and insula, which all have an important role in the modulation of emotions and inner states," said study co-author Giulia Avvenuti from the IMT School for Advanced Studies Lucca.

"In the control group, instead, none of these changes was observed. The fact that Transcendental Meditation has measurable effects on the 'dialogue' between brain structures involved in the modulation of affective states opens new perspectives for the understanding of brain-mind relationships," said Pietro Pietrini, IMT School's Director, and co-author of the study.

"It also extends the results of recent research suggesting that drugs therapies and psychotherapy leverage on the same biological mechanism," Pietrini said.

According to the researchers, even a few months of practice of TM can have positive effects which can be correlated with measurable changes in the brain.

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Agencies
June 20,2020

The World Health Organisation has warned that the COVID-19 pandemic is entering a "new and dangerous" phase. Thursday saw the most cases in a single day reported to the WHO.

Tedros Adhanom Ghebreyesus said the day had seen 150,000 new cases with half of those coming from the Americas and large numbers also from the Middle East and South Asia, the BBC reported.

He said the virus was still spreading fast and the pandemic accelerating.

He acknowledged people might be fed up with self-isolating and countries were eager to open their economies but he said that now was a time for extreme vigilance.

Maria van Kerkhove, technical lead of the WHO's COVID-19 response, told a press conference the pandemic is "accelerating in many parts of the world".

"While we have seen countries have some success in suppressing transmission and bringing transition down to a low level, every country must remain ready," she said.

Mike Ryan, the head of the WHO's Health Emergencies Programme, said that some countries had managed to flatten the peak of infections without bringing them down to a very low level.

"You can see a situation in some countries where they could get a second peak now, because the disease has not been brought under control," he said.

"The disease will then go away and reduce to a low level, and they could then get a second wave again in the autumn or later in the year."

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