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Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Kottayam, Mar 31: A 91-year-old and 88-year-old senior citizen couple were discharged from the isolation ward of government medical college after getting treated from COVID-19 on Monday.

"It is a testimony to the dedication and expertise of the medical staff as well as the strength of the Kerala public health system. We shall overcome," Kerala Finance Minister Thomas Issac tweeted as he praised the healthcare services for treating the elderly couple considered as highly vulnerable to the contagious virus.

Apart from the two senior citizens, five others suffering from COVID-19 have also been treated and discharged from the hospital.
Thomas, 91, and his wife Mariyamma, 88, who were under treatment at the Kottayam Medical College were already suffering from various age-related problems. The 91-year-old had a heart attack and severe breathing trouble when he was under treatment.

"The aged couple based in Ranni in Pathanamthitta district had got infected with the virus after coming into contact with their son, wife and grandson who had arrived from Italy. COVID-19 was confirmed in them on March 8. They were admitted to Pathanamthitta hospital. However, they were shifted to the Medical College in Kottayam the very next day as their condition was critical," the Kerala government said.

The family will have to remain in home-quarantine for 14 more days.

The Union Health Ministry said the death toll due to COVID-19 has risen to 32 and the number of total coronavirus cases to 1,251 as on Monday. 

There are 1117 active cases in the country with the state of Kerala contributing the highest number of cases which stands at 202.