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May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.

According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.

"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.

They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.

Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.

"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.

"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.

In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.

"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.

The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.

These children were then confirmed to have COVID-19.

While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.

Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.

According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.

"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.

Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.

While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.

However, he cautioned that more research is needed to confirm their findings.

"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.

Bengaluru, Mar 10: Three more positive COVID-19 cases have been confirmed in Karnataka taking the tally to four, state Health Minister B Sriramulu on Tuesday informed.

"Their family members have been isolated and their health is being monitored. I urge citizens to take precautionary measures and co-operate in preventing the spread of this infection," Sriramulu said.

As on Monday, the national tally of persons affected by the coronavirus is 45.

According to the Indian Council of Medical Research (ICMR), in the past 24 hours, one positive case from Kerala, two from Pune, and three from Bengaluru have been confirmed.

Apart from the ICMR; National Institute of Virology in Pune; 51 Virus Research and Diagnostic Laboratories; and National Centre for Disease Control, New Delhi are carrying out tests for COVID-19.

Bengaluru, Apr 10: With 10 new COVID-19 cases, Karnataka's tally of coronavirus cases has climbed to 207, the Karnataka government has said.

The 207 COVID-19 cases include 30 discharged and 6 deaths. Out of 10 new cases, 9 are close contacts of people who had earlier tested positive for coronavirus.

"10 more COVID-19 positive cases reported in Karnataka, taking the total number of positive cases in the state to 207, including 6 deaths and 30 discharged. 9 of the 10 new cases, are close contacts of people who had tested positive for the virus earlier," said the Karnataka government.

Meanwhile, the State Department of Health and Family Welfare has further notified 14 more COVID-19 dedicated hospitals in the state.

These hospitals include Bagalkot District Hospital, Chamarajanagar Institute of Medical Sciences, District Hospital Chikkaballapur, SNR District Hospital, Kandaya Bhavan Ramanagar, Tumkur District Hospital, Karwar Institute of Medical Sciences Uttara Kannada, Vijayapura District Hospital and Yadgiri District Hospital.

India's total number of coronavirus positive cases rose to 6,412 on Friday.

Out of the total cases, 5,709 are active patients and 503 of them have been cured/discharged, as per the Ministry of Health and Family Welfare.

With 30 new deaths reported in the last 12 hours, the toll stands at 199.