BJP hesitating to seek vote in Modi’s name; now it’s dependent on BSY, Sriramulu: DKS

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, May 28: A thousand government schools in Karnataka are set to get Englishmedium sections from this academic year (2020-21). These institutions will function in both English and Kannada medium.

The decision was taken by primary and secondary education minister S Suresh Kumar and officials of the education department at a meeting on Wednesday.

Suresh Kumar said dualmedium will help improve the standard of schools and enable their development. The poorest of the poor spend almost 40% of their income on their children’s education in private schools. With the introduction of dual-medium, the government hopes such families will be able to save their earnings, he said. These schools will impart lessons in both English and Kannada. They will also provide textbooks in both languages.

‘Kannada must for all’

The meeting reviewed implementation of the compulsory Kannada Language Learning Act, 2015. Officials from the Kannada Development Authority were present at the meeting who claimed that some private schools have failed to implement the Act properly.

“Action will be taken against such institutions. Every child studying in schools across the state must learn Kannada,” Kumar said at the meeting.

Bengaluru, Feb 26: Senior Congress leader Siddaramaiah said that Union Home Minister Amit Shah should issue strict orders to the police in Delhi to act in nation's interest and control the ongoing violence.

"Distressing scenes in Delhi!! #DelhiBurning as a result of ulterior motives of divisive forces within our Country. Police have completely failed in their responsibility. People have to remain calm and promote peace in the area for their own benefit," Siddaramaiah tweeted.

"Seven people dead and hundreds are injured, Amit Shah should issue strict orders to police to act in nation's interest and not in the interest of few people. As Gandhiji said, An eye for an eye makes the whole world blind. Peace and harmony should be our moto," he added.
Siddaramaiah further stated that the "triggering point of the #DelhiViolence seems to be the inciting speech of BJP leader Kapil Mishra."

"This actually qualifies for a sedition case as it was aimed at disturbing national peace and security. Police have to arrest him and bring normalcy in Delhi," he wrote.

Siddaramaiah has further asked Karnataka Chief Minister BS Yediyurappa to be careful "before situation goes out of hand."

"Delhi riots are in front of eyes. There will be tough situation here in state as well if those loose tongue leaders in BJP are not stopped in the state," he wrote.
As many as 18 people have lost their lives and around 190 are injured in the violence that has been raging in parts of North-East Delhi from Monday.