Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
 
      
Comments
Kill the killer, no need wait revenge is the good medicine in DK.. brothers dont wait search and kill them if they 3 also kill them
Ashraf is a rowdy sheeter. Why the CD report hid this fact?
inna lillahi wa inna ilayi raji'un : Surely we belong to ALLAH and to Him shall we return...
Dear SDPI ... Be patience and Use your intellect .... Dont get angry like the Ignorant do.
Seriously heart ranching murder, whoever murdered should be punished please brothers dont continue, weak heart people cant c this anymore.
you succeeded in this life and hereafter ....but who ever did it will bear the cost
INDIAN LAW IS EQUAL TO ALL
inna lillahi wa inna ilayhi raji'un
to those who dislike eye for an eye solution, what would you do if he was your blood relative? would your view be the same? wait for the investigation and wait for years and years for justice? People like you will always be around. Justice has to be done right now no matter what.
No matter if killed .....he offered the service which the killer didnt understand .......
May he be guided or he will be guided by the right way in right person and right time
strange to see the comments today lacks of people killed due to hate of religion ..and why it started in india ... guys pray for him RIP
only in india we are safe we should believe in our law
@Viren
I think you are a rowdy sheeter. Not him. he was facing not even a petty case in any police station.
Rightly said Natasha.
Serpents like Viren are spewing venom in the society and they will be destroyed
Dear Viren,
because of idiots like you. Hindu and Muslim Became enemy. There was a time when Idiots like you was not even born in our India. we used be like Brothers. May The Curse of Allah be on you/ May Allah Give u Hidayath..
Dear Coastal digest,
I m regular reader of your Website, I dont read any other news paper. I am seeing Viren Comment from years and i just control my patient. if next time i find any comments which spread hate abt Islam or Hindu or any religion and you people post it. That will be the last day and i will issue a ban poll on ur website.
Sorry if i hurt u in my words. May Allah bless you
inna lillahi wa inna ilayhi rajiwoon!
when injustice becomes law, Resistance Becomes Duety!
Silence is a Crime!
#i Stand with SDPI
Mullan Mullininda thegibeku kanoooooo
Just watch and see; it is started...........
good to see people find viren offensive ans not HANE ..
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