Brisk walking associated with 60-70% lower risk of death in women

Agencies
November 7, 2017

Washington D.C, Nov 7: A study states that more physical activity and higher intensities of exercise could decrease the risk of death in older women from any cause.

Lack of exercise or physical activity is estimated to cause as many deaths each year as smoking.

Current guidelines recommend at least 150 minutes a week of moderate intensity physical activity, or 75 minutes a week of vigorous-intensity aerobic physical activity (or a combination of the two), and muscle-strengthening exercises two or more days a week.

The study, led by investigators at Brigham and Women's Hospital, investigated physical activity of women measured over seven days using a wearable device called a triaxial accelerometer.

Moderate to vigorous intensity physical activity (e.g. brisk walking) was associated with 60-70 percent lower risk of death at the end of the four-year study among the most active women, compared to the least active.

"The fact the physical activity lowers mortality rate is nothing new - we have many studies showing this. However, previous studies have primarily relied on self-reported physical activity, and self-reports tend to be imprecise. Based on these self-report studies, we know that physical activity is associated with a 20-30 percent reduction in mortality rates, comparing the most with the least active. Using device-measured physical activity in the present study, we observed a 60- 70 percent risk reduction larger than previously estimated from self-report studies. For context, non-smokers have about a 50 percent reduction, compared with smokers," stated I-Min Lee, MBBS, ScD, associate epidemiologist at Brigham and Women's Hospital, and first author of the study.

"This study supports current guidelines for physical activity, such as those from the federal government and the American Heart Association, that emphasize moderate-intensity physical activity. It also adds to existing evidence that can inform upcoming physical activity guidelines over time."

This is one of the first studies to investigate physical activity, and a clinical outcome, using the newer generation triaxial wearable devices which have increased sensitivity to recognize physical activity and are capable of more precise measurements than the previously used uniaxial devices, or studies relying on self-reports only.

"We used devices to better measure not only higher intensity physical activities, but also lower intensity activities and sedentary behavior, which has become of great interest in the last few years," stated I-Min Lee, MBBS, ScD.

Data were analyzed from 16,741 participants (average age 72) from the Women's Health Study who wore the device for at least 10 hours a day, on at least four out of seven days.

Light physical activity, such as slow walking, was not associated with lower death rate during the study. Researchers note that light activity may be beneficial for other health outcomes not reported in this paper.

The findings have been published in Circulation.

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Agencies
March 3,2020

Taking multiple courses of antibiotics within a short span of time may do people more harm than good, suggests new research which discovered an association between the number of prescriptions for antibiotics and a higher risk of hospital admissions.

Patients who have had 9 or more antibiotic prescriptions for common infections in the previous three years are 2.26 times more likely to go to hospital with another infection in three or more months, said the researchers.

Patients who had two antibiotic prescriptions were 1.23 times more likely, patients who had three to four prescriptions 1.33 times more likely and patients who had five to eight 1.77 times more likely to go to hospital with another infection.

"We don't know why this is, but overuse of antibiotics might kill the good bacteria in the gut (microbiota) and make us more susceptible to infections, for example," said Professor Tjeerd van Staa from the University of Manchester in Britain.

The study, published in the journal BMC Medicine, is based on the data of two million patients in England and Wales.

The patient records, from 2000 to 2016, covered common infections such as upper respiratory tract, urinary tract, ear and chest infections and excluded long term conditions such as cystic fibrosis and chronic lung disease.

The risks of going to hospital with another infection were related to the number of the antibiotic prescriptions in the previous three years.

A course is defined by the team as being given over a period of one or two weeks.

"GPs (general physicians) care about their patients, and over recent years have worked hard to reduce the prescribing of antibiotics,""Staa said.

"But it is clear GPs do not have the tools to prescribe antibiotics effectively for common infections, especially when patients already have previously used antibiotics.

"They may prescribe numerous courses of antibiotics over several years, which according to our study increases the risk of a more serious infection. That in turn, we show, is linked to hospital admissions," Staa added.

It not clear why hospital admissions are linked to higher prescriptions and research is needed to show what or if any biological factors exist, said the research team.

"Our hope is that, however, a tool we are working for GPs, based on patient history, will be able to calculate the risks associated with taking multiple courses of antibiotics," said Francine Jury from the University of Manchester.

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Agencies
March 11,2020

With the sales of chicken and mutton going down due to the coronavirus scare, it is the humble 'Kathal' (jackfruit) is emerging as an acceptable alternative.

'Kathal' is now selling at ₹120 per kilogram -- an increase of more than 120 per cent over the normal ₹50 per kilogram.

The jackfruit, in fact, is now priced higher than chicken which is selling at ₹80 per kilogram due to poor demand.

"It is better having a 'Kathal' biryani instead of a mutton biryani. It tastes reasonably good. The only problem is that 'Kathal' has been sold out in the vegetable market and is difficult to find," said Purnima Srivastava whose family savours non-vegetarian food on a regular basis.

The corona scare has hit poultry business so hard and the Poultry Farm Association recently organized a Chicken Mela in Gorakhpur to dispel the misconception that birds are carriers of the deadly virus.

"In fact, we gave away plateful of chicken dishes for Rs 30 to encourage people to savour the delicacies. We cooked one thousand kilograms of chicken for the Mela and the entire stock was sold out," said Vineet Singh, head of the Poultry Farm Association.

However, the Mela did not do much to dispel the fears about chicken, mutton or fish consumption amid the virus outbreak.

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Agencies
March 27,2020

New Delhi, Mar 27: The Centre has restricted sale and distribution of "hydroxychloroquine" declaring it as an essential drug to treat the COVID-19 patients and meet the requirements of emergency arising due to the pandemic.

The Ministry of Health and Family Welfare on Thursday made the announcement making it clear that the order "shall come into force on the date of its publication in the official Gazette".

In the order, the government declared that the Central government is "satisfied that the drug hydroxychloroquine is essential to meet the requirements of emergency arising due to pandemic COVID-19 and in the public interest, it is necessary and expedient to regulate and restrict the sale and distribution of the drug 'hydroxychloroquine' and preparation based thereon for preventing their misuse".

"Now, therefore, in exercise of the powers conferred by Section 26B of the Drugs and Cosmetics Act, 1940 (23 of 1940), the Central government hereby directs that sale by retail of any preparation containing the drug Hydroxychloroquine shall be in accordance with the conditions for sale of drugs specified in Schedule H1 to the Drugs and Cosmetics Rules, 1945."

The order came at a time when the novel coronavirus claimed 16 lives and infected over 600 people across India.

The announcement regarding ban of sale and distribution of the drug was made by the government earlier but it issued an official Gazette notification on Thursday signalling that hydroxychloroquine -- an anti-Malaria drug -- will work as a medicine for treating coronavirus infected patients as well.

Recently, the national task force for COVID-19 constituted by Indian Council for Medical Research (ICMR) has recommended hydroxy-chloroquine as a preventive medication.

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