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May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.

According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.

"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.

They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.

Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.

"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.

"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.

In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.

"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.

The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.

These children were then confirmed to have COVID-19.

While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.

Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.

According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.

"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.

Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.

While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.

However, he cautioned that more research is needed to confirm their findings.

"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.

Bengaluru, Mar 25 : Karnataka recorded its highest single-day tally to date, as 10 people tested positive, taking the total number of cases to 51 in the state.

“Till date 51 COVID-19 positive cases have been confirmed in the state which includes one death and three discharged," the health department said in a statement on Wednesday.

The rise in cases adding to the growing national tally of people who have tested positive for COVID-19.

The daughter of a former union minister from the Bharatiya Janata Party (BJP) from Karnataka has also tested positive.

Bengaluru accounts for 32 of the total 51 cases recorded in the state so far,including three who have fully recovered and released.

Dakshina Kannada has five confirmed cases, Chikkaballapura and Kalaburagi has three cases each, Mysuru has and Uttara Kannada has two cases each and four other districts have one case each.

Prime Minister Narendra Modi has announced a 21-day lockdown of the country to keep people indoors and contain the spread of the virus in the community.

The government has also been trying to scale up testing.

Medical education minister K.Sudhakar on Wednesday told Mint that Karnataka will scale up testing by 10-fold with the help of government and private labs approved by the Indian Council of Medical Research (ICMR).

A total of 2,438 people have been tested in Karnataka and 2242 have tested negative, according to state health department. 214 people are lodged in medical hospitals.

Mangaluru, May 30: Coastal district of Dakshina Kannada today recorded third covid-19 death as a 67-year-old woman from Bantwal taluk succumbed to the coronavirus at the district Wenlock Hospital, the designated Covid hospital.

The victim is said to be a neighbor of two women (daughter-in-law and mother-in-law) who died of the coronavirus a few days ago. 

On April 18 due to difficulties in breathing, she was rushed to Wenlock Hospital, where she was tested positive for coronavirus. Initially she responded to treatment. However, her condition started worsening earlier this week and breathed her last today evening.

Her daughter also has been tested positive for the deadly virus and she is currently undergoing treatment.