Chemicals in fast food wrappers and clothes may lead to weight gain: study

Agencies
February 14, 2018

Feb 14: Chemicals used in food wrappers, non-stick pan coatings and clothing may boost body weight by interfering with metabolism, especially in women, US researchers said Tuesday.

These chemicals -- known as perfluoroalkyl substances (PFASs) -- have previously been linked with cancer, hormone disruption, immune dysfunction, high cholesterol, and obesity.

"Now, for the first time, our findings have revealed a novel pathway through which PFASs might interfere with human body weight regulation and thus contribute to the obesity epidemic," said senior author Qi Sun, assistant professor in the Department of Nutrition at Harvard University T.H. Chan School of Public Health.

Researchers found that PFASs -- also known as "obesogens" because they interfere with body weight regulation -- were linked to a slower resting metabolic rate.

People with higher levels of PFASs in their blood also had more sluggish metabolisms after weight loss. The study tracked data from 621 overweight and obese participants in a clinical trial on weight loss conducted in the mid-2000s.

The study looked at the effects of four heart-healthy diets on weight loss over a period of two years.

Participants also had levels of PFASs in their blood measured.

On average, those in the program lost 14 pounds (6.4 kilograms) in the first six months, but regained six lbs (2.7 kg) over the course of the following year and a half.

"Those who gained the most weight back also had the highest blood concentrations of PFASs, and the link was strongest among women," said the report in the journal PLOS Medicine.

"On average, women who had the highest PFAS blood levels (in the top third) regained 3.7-4.8 lbs (1.7-2.2 kg more body weight than women in the lowest third."

Researchers also discovered that those with higher blood concentrations of PFASs "were significantly associated with lower resting metabolic rates."

PFASs have been have been around for 60 years, and have contaminated drinking water near some industrial sites, military bases, and wastewater treatment plants.

The chemicals can accumulate in drinking water, persist for a long time in the body, and are difficult to avoid.

"We typically think about PFASs in terms of rare health problems like cancer, but it appears they are also playing a role in obesity, a major health problem facing millions around the globe," said study co-author Philippe Grandjean, adjunct professor of environmental health at Harvard Chan School.

"The findings suggest that avoiding or reducing PFAS exposure may help people maintain a stable body weight after they successfully lose some weight, especially for women."

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Agencies
May 5,2020

The lockdown forced by the coronavirus in India has had some unexpected but positive fallouts: It has brought families together and reduced corporate politics, says an expert working in the field for the past decade.

"Today the whole world is on lockdown because of COVID-19, and all that we read, talk and hear is about life and death. We can't deny that the times are tough and the future is uncertain. But I would like to turn the coin and see the other side: the positive side," Shikha Mittal, Founder Director of Be.artsy told IANS in an interview.

Be.artsy is one of India's leading social awareness enterprises which deals with emotions at work and promotes arts as a communication tool for workplaces.

"In the 21st century, personally and professionally, people are practising politics over humanity, competition over collaboration, and have lost touch with themselves due to materialistic desires. During the lockdown, we are forced to confront our existing daily lives, and two interesting things that we can ponder upon, have emerged.

"First, have we ever looked at our family with the same lens as we are using today? What is it that we are doing differently with family today, and what can we do to carry our actions of today into our tomorrow? This is the premise of the #aajjaisakalcontest" that Be.artsy has launched across India.

The aim is "to encourage people to share one habit or life skill that they never practiced earlier, but post Covid-19 would like to continue and enjoy".

How did Be.artsy come about?

"I used to be in the corporate world, earning promotions and greater responsibility. However, the work conditions in those days were unfriendly to women and I had faced many instances of sexual harassment and workplace harassment in the six years of my corporate career. And that's when I had an epiphany."

Be.artsy's most popular programmes are on Prevention of Sexual Harassment (POSH) and on Financial Literacy which makes young people financially independent and better prepared to face the corporate world. "We know that a stitch in time (of planning for the future) saves nine (debt trap, dependence, health emergencies, expenses exceeding income, no savings, families without support, retirement in poverty, lost dreams, extravagance). This can only be achieved by sensitisation," Mittal explained.

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Agencies
February 27,2020

Washington D.C, Feb 27: New research shows that adults who have low fruit and vegetable intake are more likely to be diagnosed with an anxiety disorder.

"For those who consumed less than 3 sources of fruits and vegetables daily, there was at least at 24% higher odds of anxiety disorder diagnosis," says the lead author of the Canadian Longitudinal Study, Karen Davison, who is a health science faculty member, nutrition informatics lab director at Kwantlen Polytechnic University, (KPU) and North American Primary Care Research Group Fellow.

"This may also partly explain the findings associated with body composition measures. As levels of total body fat increased beyond 36%, the likelihood of anxiety disorder was increased by more than 70%," states co-author Jose Mora-Almanza, a Mitacs Globalink intern who worked with the study at KPU.

"Increased body fat may be linked to greater inflammation. Emerging research suggests that some anxiety disorders can be linked to inflammation," says Davison.

In addition to diet and body composition measures, the prevalence of anxiety disorders also differed by gender, marital status, income, immigrant status and several health issues.

An important limitation of the study was that the assessment of anxiety disorders was mostly based upon self-reporting of a medical diagnosis.

"It is estimated that 10% of the global population will suffer from anxiety disorders which are a leading cause of disability," says Karen Davison

"Our findings suggest that comprehensive approaches that target health behaviours, including diet, as well as social factors, such as economic status, may help to minimize the burden of anxiety disorders among middle-aged and older adults, including immigrants," she concluded.

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Agencies
June 10,2020

Early treatment with the antiviral drug remdesivir has been found to reduce viral load and prevent lung disease in macaques infected with SARS-CoV-2 that causes COVID-19, according to a study.

The findings, published in the journal Nature on Tuesday, support the early use of remdesivir treatment in patients with COVID-19 to prevent progression to pneumonia.

Researchers from the National Institutes of Health in the US noted that remdesivir has broad antiviral activity and has been shown to be effective against infections with SARS-CoV and MERS-CoV in animal models.

The drug is being tested in human clinical trials for the treatment of COVID-19, they said.

Researcher Emmie de Wit and colleagues investigated the effects of remdesivir treatment in rhesus macaques, a recently established model of SARS-CoV-2 infection.

Two sets of six macaques were inoculated with SARS-CoV-2.

One group was treated with remdesivir 12 hours later -- close to the peak of virus reproduction in the lungs -- and these macaques received treatment every 24 hours until six days after inoculation.

In contrast to the control group, the researchers found that macaques that received remdesivir did not show signs of respiratory disease, and had reduced damage to the lungs.

Viral loads in the lower respiratory tract were also reduced in the treated animals; viral levels were around 100 times lower in the lower-respiratory tract of remdesivir-treated macaques 12 hours after the first dose, they said.

The researchers said that infectious virus could no longer be detected in the treatment group three days after initial infection, but was still detectable in four out of six control animals.

Despite this virus reduction in the lower respiratory tract, no reduction in virus shedding was observed, which indicates that clinical improvement may not equate to a lack of infectiousness, they said.

Dosing of remdesivir in the rhesus macaques is equivalent to that used in humans, the researchers noted.

They cautioned that it is difficult to directly translate the timing of treatment used in corresponding disease stages in humans, because rhesus macaques normally develop only mild disease.

However, researchers said the results indicate that remdesivir treatment of COVID-19 should be initiated as early as possible to achieve the maximum treatment effect.

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