Child anxiety could be a factor in school absences

Agencies

February 28, 2019

A new research now finds that anxiety can be a factor in poor school attendance among children and young people. The study, by the University of Exeter Medical School conducted a systematic review, which analyses all available evidence in the field.

The study, published in Child and Adolescent Mental Health, increases our understanding of the link between anxiety and poor school attendance, particularly when unexcused.

The research, supported by the Wellcome Trust and the National Institute for Health Collaboration for Leadership in Applied Health Research and Care (CLAHRC) South West Peninsula (PenCLAHRC), says more studies are needed that follow children over time to clearly disentangle whether the anxiety leads to poor school attendance or the other way round.

The team categorised school attendance into the following categories: absenteeism (i.e. total absences); excused/medical absences; unexcused absences/truancy; and school refusal, where the child struggles to attend school due to emotional distress, despite awareness from parents and teachers.

Findings from eight studies suggested a surprising association between truancy and anxiety, as well as the expected link between anxiety and school refusal.

Lead author Katie Finning said, “Anxiety is a major issue that not only affects young people’s schooling, but can also lead to worse academic, social and economic outcomes throughout life. It’s important that we pick up the warning signs and support our young people as early as possible. Our research has identified a gap of high-quality studies in this area, and we urgently need to address this gap so that we best understand how to give our young people the best start in life.”

Professor Tamsin Ford, who was involved in the research, further added “School staff and health professionals should be alert to the possibility that anxiety might underlie poor school attendance and can also cause lots of different physical symptoms, such as tummy and headaches”.

Lots of things about school can trigger anxiety in children and it is important to realise that while we all get anxious about somethings, anxiety that is severe can have a major impact on children’s development.

The researchers concluded that anxiety is highly treatable and there are effective treatments. It is also important to understand that anxiety can lead to impulses to avoid the thing that makes one anxious. Although this avoidance reduces anxiety in the short term, it makes it even harder to cope with the trigger next time and so makes the problem worse.

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Remdesivir slows COVID-19 progression in macaques: Study

Agencies

June 10,2020

Early treatment with the antiviral drug remdesivir has been found to reduce viral load and prevent lung disease in macaques infected with SARS-CoV-2 that causes COVID-19, according to a study.

The findings, published in the journal Nature on Tuesday, support the early use of remdesivir treatment in patients with COVID-19 to prevent progression to pneumonia.

Researchers from the National Institutes of Health in the US noted that remdesivir has broad antiviral activity and has been shown to be effective against infections with SARS-CoV and MERS-CoV in animal models.

The drug is being tested in human clinical trials for the treatment of COVID-19, they said.

Researcher Emmie de Wit and colleagues investigated the effects of remdesivir treatment in rhesus macaques, a recently established model of SARS-CoV-2 infection.

Two sets of six macaques were inoculated with SARS-CoV-2.

One group was treated with remdesivir 12 hours later -- close to the peak of virus reproduction in the lungs -- and these macaques received treatment every 24 hours until six days after inoculation.

In contrast to the control group, the researchers found that macaques that received remdesivir did not show signs of respiratory disease, and had reduced damage to the lungs.

Viral loads in the lower respiratory tract were also reduced in the treated animals; viral levels were around 100 times lower in the lower-respiratory tract of remdesivir-treated macaques 12 hours after the first dose, they said.

The researchers said that infectious virus could no longer be detected in the treatment group three days after initial infection, but was still detectable in four out of six control animals.

Despite this virus reduction in the lower respiratory tract, no reduction in virus shedding was observed, which indicates that clinical improvement may not equate to a lack of infectiousness, they said.

Dosing of remdesivir in the rhesus macaques is equivalent to that used in humans, the researchers noted.

They cautioned that it is difficult to directly translate the timing of treatment used in corresponding disease stages in humans, because rhesus macaques normally develop only mild disease.

However, researchers said the results indicate that remdesivir treatment of COVID-19 should be initiated as early as possible to achieve the maximum treatment effect.

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Pasteurising breast milk may inactivate novel coronavirus, claims study

News Network

July 10,2020

Toronto, Jul 10: Pasteurising breast milk at 62.5 degrees Celsius for 30 minutes inactivates the SARS-CoV-2 virus that causes Covid-19, making it safe for consumption by babies, a study claims.

According to the research published in the Canadian Medical Association Journal, current advice for women with Covid-19 is to continue to breastfeed their own infants.

In Canada, it is standard care to provide pasteurised breast milk to very-low-birth-weight babies in hospital until their own mother's milk supply is adequate, the researchers said.

"In the event that a woman who is Covid-19-positive donates human milk that contains SARS-CoV-2, whether by transmission through the mammary gland or by contamination through respiratory droplets, skin, breast pumps and milk containers, this method of pasteurisation renders milk safe for consumption," said Sharon Unger, a professor at the University of Toronto in Canada.

The Holder method, a technique used to pasteurise milk in all Canadian milk banks at 62.5 degrees Celsius for 30 minutes, is effective at neutralising viruses such as HIV, hepatitis and others that are known to be transmitted through human milk, the researchers said.

In the latest study, the researchers spiked human breast milk with a viral load of SARS-CoV-2 and tested samples that either sat at room temperature for 30 minutes or were warmed to 62.5 degrees Celsius for 30 minutes.

They then measured for active virus, finding that the virus in the pasteurised milk was inactivated after heating.

More than 650 human breast milk banks around the world use the Holder method to ensure a safe supply of milk for vulnerable infants, the researchers said.

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