Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer.
Udupi, Jan 24: A hilarious speech delivered by Congress leader CM Ibrahim during the recent biennial Paryaya festival in which the 85-year-old Pejawar mutt seer Sri Vishwesha Tirtha Swami ascended the Paryaya Peetha in Udupi has gone viral on social media, prompting the former’s fans and political rivals to engage in a debate.
Comments
C.M. Ibrahim..unfit to be a Muslim
Hey guys!
Don't you have anything else to do? Commenting and issuing Fatwa on each and every silly things?!!! CMI is a politician who will yell anything that yield him political mileage. And for preaching, this is not a platform for it either. May be you were not aware that the famous Lulu's Yousuf Ali donated to Viswa Hindu Parishad's International Conference in London recently.
Navoodu Billah, even we cant say Nabi Sws as god, we can only say fi Naari jahanam
No wonder if cm calls pejavara as god he has different gods everywhere ,he bow AP ustad too while AP followers say Allah Akbar to AP ..which is big shirk?
I think there is third 'walking god' which mr.ibarhim forgot to mention in his speech mr, kantapuram musliyar. Mr, ibrahim is really a lucky person for getting 'holy trinity'.!!!!
\CM\" Go adress the function but do not SALE your faith in cheap rate."
Fee nari jahannum.....
Ibrahim Lost his mind
All those who commented here failed to realize the greatest \Hikmah\" hidden behind CM Ibrahim's statement. He is just following the model of our greatest prophet Hazrat Ibrahim (a.s), who had stated that moon is god and son is god. His intention was to convince the Mushrik that they are not gods.
Similarly when those two walking gods leave this world, our CM ibrahim will go to Udupi and say: \"See all are dead. the one who is alive and will be alive forever is the only true god\"...
hahaha.. am kidding."
Dear all,
I am Not supporter of any politician........
He said that GOD, Please do Understand he did not call him \ALLAH\", When COW can become GOD Mother, why can't be Mr. Seer be a God, after all their are 33 crores of GODS.
Why should we give give importance , as called him a GOD, Let them add another GOD in the list, as RECOMMENDED BY Mr. IBRAHIM"
C. M. Ebrahim now in ATTH BITTH
Nahoodu Billhah.
Is he a real Muslim or Name sake Muslim.I really Wonder,Even Hindus do not believe pejavar sree as GOD.Nor pejavara Sree Quoted himself as a GOD.In one of his interview i heared C.M Ibrahim introduced H.D Devegavda as MANEDEVAARU.I really dont understand Why he is giving GOD'S Status to the Human being.
I know Muslims do not entertain or believe in such policies...
I do remember this CM Ibrahim's 20 year old speech in Bengaluru. He was addressing a muslim gathering. Here are the excerpts:
\Ee CM Ibrahim 100% Musalmaan. Jafar Sharif haage 50% Musalmaan alla naanu. Ee kade Maseedigu hogtare aa kade devastaanakkoo hogatare namma 'kaafar' sharif\".... Naanu eega thaane hajj maadi bandiddene\"....
And now what the hell he is saying?"
confession of hypocrisy.
First of all he does not know the main message of Islam which is oneness of God. (even if he knows it, still does not know the seriousness of God).
Ulema the scholars say 1 third of Quran(almost 200pages OR 10Parts of Quran) is only about oneness of God.
This is the key of Islam. Unless a person knows it(Oneness of God), he can not go forward to learn Islam.
Islam is based on this oneness. So, Islam does not allow for associating anything with the God. Even the Gods special qualities can also be not seen in others.
Even a negligible minute portion can not be equated to that one and only God, who controls the entire universe.
Even we can not say our mother, father also to the level of God.
It is the duty of every Muslim not to make such mistakes of equating anything with the God. This is called as Shirk associating someone with the God.
May Allah forgive our mistakes, help us to learn the fact and share with others.
What about Devegowda ? he made him party president, union minister. May Allah guide him to right path.
Why only two gods? Include Kalladka Bhat and make it three gods! Perfect Trinity
He is already Durga Poojary, it is no surprise that he says whoever God. Thee are some more big so called leaders smilar to Mr. Ibrahim's category who prays and also becoming President of Uroos etc. Even one of our Vice Chancellor also in his grade.
All these people are giving wrong signal to others about our religious.
It is welcome to go and speak at Swamys's presence but not in this level.
Marle..
La haula wala quvvata illa billah....
This fellow went to Kerala and declared AP Ustad as greatest auliya allah
Now went to Udupi and declared pejawar seer as god..
Now tell me who is great- auliya or god?
If Pejawar seer is god, who is his messenger? CM Ibrahim himself?
When U depend on Gori rituals it will take you to this height.. Graves are not for asking prayers. it is to reminds us muslims to recognise the blessing of ALLAH and our fate to end up in the graves. When we make the Graves our protector. The end result will take YOU to such steps which doesnt recognise the TRUE creator even after praying and making zikr hundreds of times...
If U ask, Ask ALLAH alone and trust him. Never depend on something which prophet muhammd pbuh never taught us. ALLAH is our protector - No need any intermedite to reach our creator. AL -hamdullillah.
The photo is very suitable for this report. CM Ibrahim raising his finger and reciting Kalima shahadah... \Ash-hadu Pejawar swami bla bla bla...\""
Yes Yes... Pejawar seer is god for saabis like CM Ibrahim.. Not for Hindus, for whom he is just a great swamji.. We are upper religion. our relgion's seers are their religion's gods... ahahaha
To Fathima, Dubai. Your statement is wrong. How you agree two god. Do you have sense. If you think like that, you done shirk. So make thouba and pray almighty Allah for your wrong statement.
He is an opportunists!
Baqoul shayer (about politicians )
Unka kiya hai ?
Wo to apne baap bhi badaltey hai !
This is the sign of Jaahil!
Ok Ok. Karnataka has two gods.. agree.. Now tell me Kerala has how many gods??? Only one?
If he belives there if God other than Allah , He is no more Muslim.
If he Belive There is God other thean Allah , He is no more
There no GOD but ALLAH.. and QURAN challenges the creation to VERIFY what is said in the QURAN to prove false... If U dare please TRY.
ALLAH says in QURAN : Say \ If the mankind and the jinns were together to produce the like of this QURAN, they could NOT produce the like thereof, even if they helped one another\" - QUran 17:88
And if YOU are in doubt concerning that which WE have sent down (The QURAN) to our slave (Muhammad pbuh) then produce a surah(chapter) of the like thereof and call your witnesses (supporters and helpers) besides ALLAH. if YOU are TRUTHFUL - Quran 2:23
Worship the CREATOR not his CREATION."
SSF's spokes person. lol
There is no GOD but ALLAH & Muhammd pbuh is last and final messenger of GOD who came after prophets like Jesus, moses, abraham, noah and Adam and several other messenger that ALLAH has sent to the people who worshiped the man made Gods and idols. Their only concern was people should worship the CREATOR who created us all. & not fall TRAP to the so called gods which is man made...
CM ibrahim is showing and strengthening u to the path of FALSEHOOD which he himself need to answer to the one who gave us Soul.
Dear HINDU brothers ... Look for QURAN , u will be cleared of who is GOD and Who are the agents of Devil which is also a creation of God.
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