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Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Kasaragod, Mar 23: The district administration on Monday decided to abandon efforts to map out the movement details of the NRI who came from Dubai recently and came into contact with many in North Kerala.

The district has been completely locked down since Monday morning, on the directive of the Central Government. Prohibitory orders have been slapped in the district since Sunday night to restrict socialisation of the people.

As the person now in isolation have allegedly been non-cooperative, the authorities were finding it difficult to sketch out a rote map as his movement and socialisation has been so vast and wide since his arrival here on March 12.

The middle aged and popular NRI who landed at Karipur airpprt on March 11 had been in Calicut till midnight prior to boarding the Maveli Express to make it to his hometown Kasaragod, which is 160 kms away from Calicut. He had come into contact with very many, including two MLAs of the district, prior to getting tested positive and getting isolated in the hospital.

Mangaluru, Feb 16: An elderly woman from Tamil Nadu was on Saturday reunited with her daughter and son after 14 years at the Mangaluru's White Doves destitute home.

"Mary only knew her name when she came here 10 years ago. Recently, she told us about her home town," Corrine Rusquinha, founder of White Doves told media.
Mary had gone missing 14 years ago from her hometown Kortampet in Tamil Nadu.

"Ten years ago, she was spotted by Mangaluru police who brought her to White Doves home late one evening. Initially, she could only speak Tamil, so it was presumed she was from Tamil Nadu. She was on psychiatric treatment," Rusquinha said.

A few days back, a visiting priest at the White Doves home spoke to Mary in Tamil and asked about her hometown.

"Surprisingly, she could recall the name of her hometown, following which the visiting priest contacted the pastor at Kortampet. Mary's family, including her daughter Gnana Anthony, who is a paramedic student in Coimbatore, was informed about Mary," she said.

Soon after, Gnana and her elder brother came to Mangaluru to take their mother back to their home.

Mary's husband Jhonson, who worked as a cook, had died within a year of losing his wife.