Cold weather may up heart failure risk in elderly: study

Agencies

September 27, 2017

Toronto, Sept 27: Exposure to cold or high-pressure weather may trigger events leading to hospitalisation or death in elderly patients with heart failure, a study has warned.

Researchers at Universite Laval and Universite de Sherbrooke in Canada suggest that elderly patients with heart failure should avoid fog and low cloud in the winter as a preventive measure.

Previous research has shown that changes in the weather can affect the health of vulnerable people - for example, heat waves and cold spells have been shown to increase disease and even lead to death in people from low-income neighbourhoods.

Researchers studied the impact of changes in temperature and air pressure on heart failure patients. The team assessed 112,793 people aged 65 years and older who had been diagnosed with heart failure in Quebec between 2001 and 2011.

The participants were followed for an average of 635 days. During this time, the researchers measured the mean temperature, relative humidity, atmospheric pressure and air pollutants in the surrounding environment and studied the data to see if there was an association.

The study, published in the journal Environment International, showed a higher risk of hospitalisation or death in the winter period of the year (October to April) compared to the summer period (May to September).

Researchers noticed that the risk to experience hospitalisation or death of heart failure cause was increased of 0.7 per cent for every one degree Celsius decrease in the mean temperature of the previous seven days.

They also found that the risk of heart failure incident increased by 4.5 per cent for each increase of one kilopascal (kPa) in atmospheric pressure.

In other words, a drop of 10 degrees Celsius in the average temperature over seven days, which is common in several countries because of seasonal variations, is associated with an increased risk in being hospitalised or dying of heart failure of about seven per cent in people aged over 65 diagnosed with the disease.

"Our study suggests that exposure to cold or high- pressure weather could trigger events leading to hospitalisation or death in heart failure patients," said Pierre Gosselin, professor at Universitie Lava.

"This means that they should avoid exposure to fog and low cloud weather in winter as they often accompany high pressure systems," said Gosselin.

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'Children under the age of 5 carry higher levels of Covid-19'

Agencies

August 2,2020

Washington, Aug 2: Children under the age of five have between 10 to 100 times greater levels of genetic material of the coronavirus in their noses compared to older children and adults, a study in JAMA Pediatrics said Thursday.

Its authors wrote this meant that young children might be important drivers of Covid-19 transmission within communities -- a suggestion at odds with the current prevailing narrative.

The paper comes as the administration of US President Donald Trump is pushing hard for schools and daycare to reopen in order to kickstart the economy.

Between March 23 and April 27, researchers carried out nasal swab tests on 145 Chicago patients with mild to moderate illness within one week of symptom onset.

The patients were divided into three groups: 46 children younger than five-years-old, 51 children aged five to 17 years, and 48 adults aged 18 to 65 years.

The team, led by Dr Taylor Heald-Sargent of the Ann & Robert H. Lurie Children's Hospital, observed, "a 10-fold to 100-fold greater amount of SARS-CoV-2 in the upper respiratory tract of young children."

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The authors added that a recent lab study had demonstrated that the more viral genetic material was present, the more infectious virus could be grown.

It has also previously been shown that children with high viral loads of the respiratory syncytial virus (RSV) are more likely to spread the disease.

"Thus, young children can potentially be important drivers of SARS-CoV-2 spread in the general population," the authors wrote.

"Behavioral habits of young children and close quarters in school and daycare settings raise concern for SARS-CoV-2 amplification in this population as public health restrictions are eased," they concluded.

The new findings are at odds with the current view among health authorities that young children -- who, it has been well established, are far less likely to fall seriously ill from the virus -- don't spread it much to others either.

However, there has been fairly little research on the topic so far.

One recent study in South Korea found children aged 10 to 19 transmitted Covid-19 within households as much as adults, but children under nine transmitted the virus at lower rates.

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Govt revises dosage of anti-viral drug remdesivir to be administered to coronavirus patients

Agencies

July 4,2020

The Union health ministry on Friday revised the dosage of anti-viral drug remdesivir to be administered to coronavirus patients in the moderate stage of illness from the earlier six days to five days as it issued an updated 'Clinical Management Protocols for COVID-19'.

The drug, administered in the form of injection, should be given at a dose of 200 mg on day one followed by 100 mg daily for four days (total five days), the new treatment protocols stated.

The Health Ministry on June 13 had allowed the use of remdesivir for restricted emergency use in moderate cases under "investigational therapies".

"Under emergency use authorisation, remdesivir may be considered for patients in moderate stage requiring oxygen support," the document stated.

It is not recommended for those with severe renal impairment and high level of liver enzymes, pregnant and lactating women, and those below 12 years, it said.

The ministry also okayed off-label application of tocilizumab, a drug that modifies the immune system or its functioning, and convalescent plasma for treating COVID-19 patients in the moderate stage of illness as "investigational therapies".

It also recommended hydroxychloroquine for patients during the early course of the disease and not for critically-ill patients.

On June 27, the ministry had included an inexpensive, widely used steroid dexamethasone in treatment protocols for COVID-19 patients in the moderate to severe stages of their illness among other therapeutic measures.

The ministry advised use of dexamethasone, which is already used in a wide range of conditions for its anti-inflammatory and immunosuppressant effects, as an alternative choice to methylprednisolone for managing moderate to severe cases of coronavirus infection.

India's COVID-19 cases soared by over 20,000 in a day for the first time taking the country's total tally to 6,25,544 on Friday while the death toll climbed to 18,213 with 379 new fatalities, according to the Union Health Ministry data updated at 8 am.

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