May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.
According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.
"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.
They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.
Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.
"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.
"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.
In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.
"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.
The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.
These children were then confirmed to have COVID-19.
While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.
Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.
According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.
"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.
Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.
While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.
However, he cautioned that more research is needed to confirm their findings.
"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.
Comments
He has made our Mangalore proud. Congratulations Dear.There are lots of youths are their like Gururaja. Unfortunately without proper education , finance and proper guidance they could not achieve anything.
Most of them are under the fold of Sangha Pariwar, where their rich leaders sends there own children abroad for education and they use these boys for goondasm in Mangalore.
nice lift, hardwork came to like a fruit.
really great, working for indian airforce only a big achievement,. clubbing to that he took gold medal in weight lifting, proud to be mangalorean.
parents really lucky to have this kid, god bless u all
awesome lift, deserve the golden medal,
Congratulation Mr. Gururaj... Good Luck ...
Not only a Tuck driver, even a lowest in the man made caste system cam also participate and they are also a human being.
He is in the open society. He can dream and accomplish it.
The constitution is secular, but the people of some sects are making polarization.
The God has not made such division.
Parents must be proud of him, did a very good achievement.
excellent, well done all the best keep up the winning movement.
Congrats Gururaj,U have made the country proud.All the best for Olympics.
Rich Muslim Fathers Son(Father in Gulf,Father big business in Mlore) from Mangalore roams in City Center/Forum...hahaha...Wa avasthe marre.Care ijji.
Marali schoolige alla...dakshina kannadada makkalige bekirudu Shale/Colleginalli sari daarige/100% markige.
Just go and see Aloysius/Milagris muslim students mark....hahaha...lagadi pother matha....ONLY JOLLY.
live example for poor family kids, if someone want to get success they dont need anybody, hardwork make them success.
we are proud of you, a national salute to the brave boy.
well done boy, keep it up and congratulation.
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