Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
Comments
Rakesh
why sit in DOHA come to INDIA and start \Swatch Bharath\" before that clean your \"dirty mind\""
nationals=those are protest peacefully .
anti nationals=beating the people, taking law in hand, not respecting supreme court order,abusing people.
now decide who is antinational.
Dear Mohammad and Syed Jubail, Every one has a right to say his opinion or comment on any issues. so please refrain yourself from wrong comments.
Thanks to PFI to register their unhappy on Ananth statement against Islam and Muslims.
#4 RAKESH DOHA, BE CAREFUL YOU ARE NOTED BY PFI ACTIVISTS FROM DOHA.....DONT COMMENT SUCH A HARSH WORD TO MUSLIM COMMUNITY....
Rakesh Doha, Kindly refrain from commenting against muslims as you are in a muslim country and should be thankful that your daily bread is coming from muslims. First clean your thinking SWACH BRAIN
Sagar & Rakesh please give one anti national activity of PFI...
But for RSS so much available....Sindhagi flag, major bomb blast - Ajmer Dargha, Mecca Majsid, samjota Express, demolition of Babri Masjid and lot more...
We all knew after Modi government u all people are frustrated....u all require a change now better all chaddi gang migrate to Nepal because no one will disturb u there...
azadi from PFI, well known anti national group, let me give one example if your true believer of god your should support all the religion. bhagwan commented against hindu god !!! if u people are not anti national u have to protest against that also. clearly pfi related all people and groups are anti national. if u want a wonderful national please avoid protest against the one who commented on u, your god, protest against effects on each and every one,
KICK OUT RSS FROM THIS BEAUTIFUL COUNTRY....THEY DONT DESERVE TO BE A PART OF THIS LOVELY COUNTRY.......I LOVE MY INDIA
I HATE RSS IN INDIA
WE WANT AZAADI FROM RSS, VHP,BD SRS, ANTI NATIONALISTS GROUP....
SAVE INDIA FROM RSS
PFI is only hope for the future
People criticise only those who work for the community....as you see that RSS was attacking MULIMS verbally and physically ....but time has changed .....it now attacks verbally PFI (as it has no guts to face PFI physically) because PFI fight to the limit against any elements which is against our constitution and against any Fascist so called Powers and against Anti nationals like Muthaliks who hoisted Pakistan flags
by the way we forgot that Govts taken the Sindhagi Flag issue than JNU fake slogan issues...this is real Fascism
come on people ...dont here gossips against Popular Front of India ...its all Gossips either from So called Secular Muslim leaders who for their self interest go against it ...or RSS who are seeing PFI as thret to their ultimate Goal of Brahminism INDIA
u guys cannot do anything , what happened to baby nirbhaya ( fake case) , all people know about your community mentality .instead of do some good job like swach bharath . we dont see no proactive lead taken by muslim community on this part .
guilty must be punished, good luck pfi u will get justice.
anti national protest, anti national party of india.
PFI doing good protest, protest till ananth gets maximum punishment.
Add new comment