ABVP activists attack college girl, then accuse her of raising pro-Pak slogan

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, Jun 1: Karnataka's Department of Health and Family Welfare on Sunday released the protocol for inter-state travellers to the State during phased reopening --#Unlock1.

Five points protocol in this regard are: 1. Mandatory Self- Registration on Seva Sindhu Portal by all travellers before entering Karnataka:

a. Name, Address and Mobile Number to be provided

b. No approval required

c. Use of same Mobile number for multiple registrations not allowed except in the case of a family.

d. Business visitors to give details (name, mobile and address of persons in Karnataka they intend to meet).

e. Transit travellers to provide an address in destination state and indicate exit check post from Karnataka.

2. Health Screening of all incoming persons at entry points.

a. Border Check-posts, Airports, Railway stations and Bus stand

b. Home Quarantine hand-stamping on hand for 14-days period as per quarantine norms

3. Quarantine norms are based on three parameters

I. Symptomatic on arrival from any State: 7 days of Hospital isolation at COVID Care Centre(CCC)/Dedicated COVID Health Centre (DCHC) followed by 7 days of home quarantine or manage as per symptoms.

II. Test immediately on arrival: If positive, shift to Dedicated COVID-19 Hospital (DCH). If negative, no further test required

III. Asymptomatic on arrival:

* For persons coming from Maharashtra

a) 7 days of institutional quarantine followed by 7 days of home quarantine

b) Test if they develop symptoms during the quarantine period

c) Exceptions for Special Category Asymptomatic persons--14-days home quarantine (one attendant to be permitted) and Special category passengers--Death in the family, Pregnant Women, Children aged below 10 years, Elderly aged above 60 years, Serious illness, Human Distress

d) Business travellers from Maharashtra: To establish that one is a business traveller, a person should show confirmed return flight/train ticket which should not be more than 7 days later from the date of arrival.

In case one is coming by road, he/she should provide the address proof of person in Karnataka he intends to meet. In addition, the person should produce -- one having COVID-19 negative test certificate, which is not more than two days old -- exempted from quarantine.

One does not have a COVID-19 negative test certificate, such a person should go for institutional quarantine of two days within which COVID-19 test should be conducted at his/her own cost. After the test result is negative, the person is exempted from quarantine. No hand stamping of the business visitor is required.

e) All travellers from Maharashtra who come with COVID-19 negative test certificate from an ICMR approved lab, which is not more than two days old from the date of arrival, are exempted from seven days of institution quarantine. They can be asked to go for 14 days of home quarantine.

f) Transit traveller from Maharashtra: To establish that one is a transit traveller, a person should show flight/ train ticket for the onward journey which should not be more than 1 day later from the date of arrival. In case one is travelling by road, he/she should provide the identity proof and address proof in the destination state. Such traveller should be hand stamped if travelling by road as "Transit Traveller."

*For persons coming from other States

a) 14 days of home quarantine

b) Test if they develop symptoms during the home quarantine period

c) For persons where home quarantine is not possible, then institutional quarantine should be done, especially when we have a large family or no separate room for home quarantine, slum or overcrowded areas where home quarantine can not be followed.

d) Business visitors from the Other States: To establish that one is a business traveller, a person should show confirmed return flight/train ticket which should not be more than 7 days later from the date of arrival. In case one is coming by road, he/she should provide the address proof of the native State. No quarantine, and no hand stamping for business visitors from other states.

e) Transit traveller from the other States: To establish that one is a transit traveller, the person should show flight/train ticket for the onward journey which should not be more than one day later from the date of arrival. In case one is travelling by road, he/she should provide the identity proof and address proof in the destination state. Such traveller should be hand stamped if travelling by road as "Transit Traveller."

4. Home Quarantine: Home quarantine follow-up for all incoming persons except business visitors and transit travellers

A. For Rural Areas--

* Home quarantine poster on the home door.

* Information to two neighbours

* Gram Panchayat Task Force to carry an overall responsibility of Home Quarantine

* 3-Member team in every village to monitor

* Flying Squad: FIR against violation of home quarantine and shift to institutional quarantine

* IVRS Call-centre outbound calls

* Quarantine watch App-daily self-monitoring upload-Temperature, Finger-tip pulse-oximetry for elderly and persons with co-morbidity

B. For BBMP and other Urban Areas--

* Home Quarantine Poster on the home door.

* Information to two neighbours and resident welfare/apartment owner's association.

* Ward level team to carry an overall responsibility of home quarantine

* 3-member team at booth level to monitor along with the involvement of Resident Welfare/Apartment Owners' Associations

* Flying Squad: FIR against violation of home quarantine and shift to institutional quarantine

* IVRS Call-centre outbound calls

* Quarantine watch App: Daily self-monitoring upload- temperature, finger-tip pulse-oximetry for elderly and persons with co-morbidity

Karnataka government on Sunday issued guidelines, which will come into force from June 1 and continue till June 30.

According to the new guidelines, religious places and places of worship for the public, hotels, restaurants and other hospitality services, and shopping malls will be permitted to open from June 8.

Union Ministry of Home Affairs (MHA) on Saturday announced new guidelines for phased re-opening of "all activities outside containment zones for the next one month beginning June 1.

In an order, Karnataka government said that phased re-opening of areas outside the containment zones, all activities will be permitted, except the following, which will be allowed, with the stipulation of following Standard Operating Procedures (SOPs) to be prescribed by the Ministry of Health and Family Welfare (MoHFW).

According to the Union Health Ministry, there are 2,922 confirmed COVID-19 cases in the State including 1,877 active cases, 997 recovered and 48 deaths.

Mangaluru, Apr 4: Dakshina Kannada district deputy commissioner (DC) Sindhu B Rupesh in an official reminder has ordered milk unions to disburse about 5,000 litres of milk to residents of notified and non-notified slums, construction labourers and migrant labourers and their families in shelters in the district.

A decision regarding the free distribution of milk to such needy families was taken in a meeting by the chief minister on April 1.

The DC has ordered cooperative milk unions in the district to distribute milk to such families from April 4 till April 14.