Students go on cleanliness drive to create awareness

Mangaluru, Jan 3: A young entrepreneur reportedly jumped off the Netravati bridge near Thokkottu on the outskirts of the city today morning.

The youth who allegedly committed suicide has been Navesh Kottari, 30, a resident of Ullalbail. He was the proprietor of N J Shamiyana.

The incident took place at around 6:30 a.m. Police and fire brigade rushed to the spot after sometime and launched search operation for the body in the river Netravati.

The body was retrieved in the afternoon.

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, May 9: A three-year-old boy was killed by a leopard in the early hours of Saturday in Magadi taluk near Bengaluru.

According to police, the boy identified as C Hemanth, was sleeping with his parents - Chandrasekhar and Mangalagowramma - outside his grandfather Chikkanna's residence at Kadaraiana Palya.

The couple, residents of Dodderi, near Big Banyan Tree (Dodda Alada Mara), had been staying at Chikkanna's [Mangalagowramma's father] residence since past a few days following the outbreak of COVID-19 epidemic in Bengaluru.

Some of the family members, with the child, had slept outside the residence on Friday as the temperature was high. The feline might have taken the child between 1.30 a.m. and 4 a.m., and killed it on the outskirts of the village, said the sources.

After a frantic search, family members and villagers found the mutilated body of the child in the early hours. The leopard had left the partially devoured body on the outskirts of the village, added the sources.

According to the villagers, many felines have been prowling in the area, probably arriving from forests around Magadi and attached areas, for the last several weeks.

The Forest Department officials said that they have launched an exercise to trap the animal by placing cages with live baits.

According to preliminary investigations, the child was killed by a leopard. Pugmarks were found near the body. A detailed investigation and post-mortem report will find the exact cause for the death.

The incident has sent shockwaves in the vicinity of the village. According to the sources, people are planning to launch a protest to condemn the killing of the boy.

Minister for Forest and Environment B.S. Anand Singh has announced a compensation of ₹7.5 lakh to the family of the victim.

Accompanied by Bengaluru Rural Lok Sabha member D.K. Suresh, Magadi legislator Manjunath and senior officials, Mr. Singh visited the place on Saturday morning.

Addressing media persons, he said that the department has decided to start combing operations for the leopard.

Mr. Suresh said the leopard might have come from Thippagondanahalli reservoir's catchment area on the outskirts of Bengaluru. The leopard has already tasted the blood of the child and hence the department should initiate immediate action [as the chances of the feline becoming a man-eater is high, Mr. Suresh added.