Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
Comments
great work IFF MAY ALLAH BLESS UR WORK
Good work done by Indian Feternity Forum and all the Donors. May Allah accept their good deeds.
IFF has been doing social works from many years for NRIs in KSA on humanity base.
great relief for family. Good work by IFF.
Good work by IFF team .
Congratulations to the persons released, the families, Mangaloreans, Kannadigas, all Indians in India and abroad. Good efforts and good work by IFF. Hatts off to their team and all those who have supported in this case. Its easy to comment. Not an easy task when we are out of our homeland. The cases runto generations.
Dear Brother Bunaz, Appreciate your comment and I know its very easy to sit inside the AC room and comment about the scenario at the end.
You defintely lack knowledge in this matter.
Their actual prison period was 8 years, but they were unable to come out as they were charged with huge fine of SAR 6.7 millions. IFF coordinated very well with Consulate and other officials and Lawyer was appointed by IFF as well. Finally they were successful in reducing the fine amount.
Thats when generous good hearted Mangalorean Business men joined their hands to support IFF to pay the needy amount.
If need be please contact nearest IFF office if you need further information on this.
Masha Allah great work by iff , without iff effort and doners it couldn't happend. I closely watch this issue , and iff also donated some part of amount in this case and effort also done by iff. So some political party taking this opportunity by wrong way. When they had power they couldn't do any single help for this guys. But now they need name in this. Any how people will know about iff . They don't need any name , Masha Allah by there work and effort people recognized iff by lot of cases handled by iff. We know recently they had work for jubail incident, helped there family members to took body to india. Masha Allah great work by iff , keep it up . May Allah bless u both iff and doners . Ameen ya rub
Masha Allah good work by IFF. keep going.
And Bunaz..if you think making follo up with authority to get them released then you should have tried.
Don't get jealous ..try to appreciate people's work or keep quite.
In many years Iff and other organizations tried to solve but unfortunately they couldn't do that .
I don't agree without donor it could be .
Then why IFF couldn't do in the early years
They got enough punishment 13 years in jail . Easily IFF got credit
May Allah bless the donors
Alhamdulillah....good job done by iff and some indian businessmen in jubail.
Alhamdulilla
A big salute to kind heart generous Mangalorean business fraternity. without their help it was impossible to get release.
Great job INDIAN FRATERNITY FORUM (IFF)... It was really a long struggle .... Alhamdulillah at the end of the day u have done really a great job ...... May Almighty Allah reward you...
Alhamdlilah...
Masha Allah ..great work IFF had taken up issue and hard work with support of Indian businessmen, dua of all
May Allah give good health those who work behind this issue, keep doing hard work towards to humanity.
Masha allha great work by india fraternity forum .
with the help of great business donor's ,
may allha bless both of them.
Well done IFF
Great work IFF Masha Allah, May Allah Accept the good deed.
Masha Allah Great Work 'Indian Fraternity forum (IFF) Allah Accept all u r good deeds..
The highest credit should go to Mangalorean Businessmen who paid a huge amount of money to STC. Without their contribution it would have never been a release for them. IFF coordination is also appreciable.
The youngsters should learn the lesson from this episode that to earn money they should not go for a haram way to become a quick rich. There are still lots of people who are doing wrong way to earn money in the gulf. It is a warning call for all of them.
Masha Allah....Great work Indian Fraternity Forum (IFF)
Masha Allah great job done by India Fraternity Forum, kudos to all the donars who joined hands. May allah accept all these things from you. Expatriates in the kingdom are still facing many issues, request with IFF and all selfless donars to join togather and work for the needy.
This is great Achievement of India Fraternity forum. Keep It up.
Masha Allah
Great Work done by IFF.
Masha ALLAH ...great job done by India fraternity forum with the support of kind hearted business people's, this shows if we unite to serve the community with all kind of support, nothing is impossible. ALLAH may accept this good deed and give it's hajar to one all, those who directly or indirectly supported this ...IFF hats off ... continue your service to the community...!!
Great work from INDIA FRATERNITY FORUM (IFF).... MASHALLAH
Well done IFF, it was not an easy case to handle yet Iff has achieved it and released them and made their families happy , truly the rewards for this will be given by ALLAH immensely .
May Allah accept the noble work and keep doing this kind of social work to humanity
Great Work IFF and Team! Keep it up!!
Great Work IFF Masha Allah!! May Allah Accept the good deed!!!
Congratulations IFF May Allha accept all ur good deeds....
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