Mangaluru: Bombay Residency opened

Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Bengaluru, Jul 20: Janata Dal (Secular) leader HD Kumaraswamy has urged the Karnataka government to stop putting warning signboards in front of COVID-19 patients' houses alleging that they are leading to "social discrimination and untouchability" in the present times.

"A local government warning signboards in front of the homes of COVID-19 infected people is leading to neo-social discrimination and untouchability in the new age. Even after infection, the individual and family should live with dignity. The government should immediately stop the practice of placing signboards," Kumaraswamy's first tweet read.

"Instead of placing them in front of their homes and creating untouchability, send health workers to their homes to create courage and awareness. They should be told not to leave the house. There is no such degrading practice left behind. I would like to ask Chief Minister Karnataka BS Yediyurappa to pay attention to this," he added.

The former chief minister further said that threatening to cancel the licenses of medical colleges for refusing treatment to patients would not solve the problem and urged the government to take them into confidence instead of rebuking them.

"Refusing treatment is the fault of any hospital. But for the same reason, threatening to cancel government medical college licenses is not right. There is no profit in this emergency of health. MCI also has the power to revoke the licenses of medical colleges. Remember not the government," he said.

"In this case, the government should look to the Medical Colleges to get their services in order to get them to trust them instead of getting angry. Let them focus on meeting their needs. I insist on a collective fight against the coronavirus through this," he further added.

The COVID-19 count in Karnataka reached 63,772 on Sunday, including 39,370 active cases and 23,065 cured and discharged patients.

Bengaluru, Jun 4: All shops, offices, malls, commercial establishments and others in Karnataka must not allow Covid-stamped people to enter their premises before the completion of the prescribed quarantine time, said a top official on Wednesday.

"They should not allow those with quarantine stamp to enter before the end of their quarantine period or till they get current Covid negative test report," ordered Chief Secretary T.M. Vijay Bhaskar.

Bhaskar has also issued the order to all religious places, hotels and others to first check for quarantine stamp on all their customers or visitors before they enter the premises.

"All shops, commercial establishments, offices, factories, malls, religious places, hotels and etc.. are required to check for quarantine stamp on all their customers or visitors before they enter the premises," he said.

In the event of a violation, Bhaskar said the police should be informed at 100.

He issued the same order to the general public and resident welfare associations asking them to be vigilant.

"General public and resident welfare associations are advised to report any violation of the quarantine in their neighbourhood to the police at telephone number 100," said the chief secretary.

The orders came under the head aRole of general public, resident welfare associations and commercial establishments''.

General public, commercial establishments and resident welfare associations have been empowered to report quarantine violations at a time when many activities are set to reopen from June 8 as part of Unlock - 1, after more than two months of lockdown.