May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.
According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.
"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.
They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.
Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.
"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.
"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.
In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.
"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.
The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.
These children were then confirmed to have COVID-19.
While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.
Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.
According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.
"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.
Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.
While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.
However, he cautioned that more research is needed to confirm their findings.
"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.
Comments
Masha Allah
Congratulatuions Sister Fathima all the very best for your future.
Mabrook Fathima Keep it up
Mash Allah , Great Job Done By Fathima and one of the toughest Job on earth is Indian CA, Great Fathima you made Muslim Community Proud .
Masha Allaha,,, Good Achivement.. keep it up.. sis.
I think he is talking about His own Party.
KESARU = RSS, KAMALA = BJP
Great achievements fathima hamza congratulations, let fulfill your future studying dream Masha allah.
Sudhar Javo Naren. Dont waste your valuable life. Be clean minded and clean hearted. Pray for your right guidance from Almighty God.
Ma Sha Allah Sister.. May Allah bless you in all your future steps..
Frustated person is disliking all comments. :D Sudhaar jaao yaar abhi bhi bahuth waqt hey
Congratulations fatima .may Allah bless you in good health and knowledge
kesarinalli kamala...
Masha Allah alf mabrook. Excellent performance.keep it up
Fathima ,you made your parents ,family and our community proud.
you made us BWF very proud, and myself and on behalf of BWF congratulations for your bright future. Let All your hopes and dreams be fulfilled
Masha Allha.. congratulations..
ALHAMDULILLAH. ALF MABROOK AND CONGRATULATIONS TO MS.FATHIMA HAMZA, & HER PARENTS MR.HAMZA ABDUL KHADER & MRS.ZAINAB MUMTAZ & THE WHOLE FAMILY., WHO ARE CLOSELY KNOWN TO ME AND MY FAMILY. IT IS A VERY GLAD NEWS TO HERE ABOUT THIS GREAT ACHIEVEMENT OF PASSING OUT HER CA EXAM IN FIRST ATTEMPT, MASHA ALLAH. IT IS CLEARLY EVIDENT HERE ABOUT HER DEDICATION, COMMITTMENT, HARDWORK & FOCUS ON THE SUBJECT, WHICH GAVE HER SUCCESSFUL RESULT. OFCOURSE, PROPER GUIDANCE AND UPBRINGING BY HER PARENTS. MAY ALMIGHTY ALLAH BLESS HER & HER PARENTS & FAMILY WITH HIS MERCIFUL AND BOUNTIFUL BLESSINGS AND ALSO A SUCCESSFUL PROFESSIONAL AND PERSONAL FUTURE FOR HER, AAMEEN.
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