Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
Comments
KAR-NATAKA...
:(
Most of the picture shows they are laughing also the police.. Which raises question of understanding!
Der was a statement frm our Dept regarding d stiff action. Is dis called stiff action?
Stiff action wud b a reality if scenario was different, if muslims was protest without permission.
Double standard
why laathi is not working here ??
Enough drama...Dirty politics...
Wah eth maryadeyna janaklu.. and oh my deware what a huge huge dozens of crowds.. oh my deware i cant even count how many they are :D
You foolish guys, Tippu did not destroy temples but in fact he built them and renovated them all....
In fact you destroyed babri masjid a few years back....how bad you guys are....moreover killing innocent muslims at that time and as well during modi's regime in Gujrath...bad people....
Tippu Zindabad!
How they laugh each other like children are playing. this is nothing else they know each other very well because both are chaddis.
In delhi how they drag Najeeb's mother .
well done BJP protest till end.
Kateel is a elected Member of Parliament. He should keep it in mind that all community from his constituency voted for his current position.
Every indian can protest. Then why Mr. Kateel is not participating in Muslim or Christian community protest?? Amazing
discrimination.
Wa/ Wa Master Kateel you Criminal looters thought to do some Loot Pat because of the Great Warriors Name!!!!!! Bap Ray Bap Which Part of the world you are in??? when you Criminal Looters thinking what?? we all understand you are all workless and how long you can leave this type of Life???? what you think being MP??
Never ever see like you Buffoon!!!
\Every Dog has its own day Kateelanna\"
Jai Hoo Siddanna,
Jai Hoo Parmarashwaranna."
let them do jayanthi or kabur whats the problem for u guys. please leave the place and queue up in the bank to exchange the notes.
Most of pics.. laughing each other. Protesters & Police.
conspiracy between Protesters and Police \YOU PRETEND LIKE BEATEN UP AND I PRETEND LIKE BEATING UP\""
Why police released all of this Gundas. Police should have done lati charge and put all of them behind bar under gunda act. Instead of carrying them like babies police could have beaten them with lati. Because of these anti national elements ad terrorists our india is in danger. Please punish them all including our useless MP.
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