Mangaluru: Thousands throng funeral of Mustafa Kavoor

Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Bengaluru, Apr 14: Despite lockdown in the country to contain the spread of coronavirus, former chief minister of Karnataka and Janata Dal-Secular leader, HD Kumaraswamy has decided to go ahead with marriage of his son Nikhil.

"Marriage will be performed in closed doors among the family members, which may be around 50 people. Family members only will be present in the marriage and all the precautionary measures will be followed as per the guidelines given by the government," Kumaraswamy said.

Nikhil Kumaraswamy, who contested Lok Sabha election from Mandya, is also the national youth wing president of Janata Dal-Secular. His marriage has been fixed with niece of former Congress minister M Krishnappa on April 17.

"Date was fixed months ago and we canot miss the good star and holy muhurtham. That is why we have decided to perform marriage on the fixed date among the family members," he said.
Marriage will be performed at bride Revati's residence.

Earlier Kumaraswamy and family had plans to perform the marriage at a location near Ramnagar, which is also former chief minister's constituency.

Bengaluru, Mar 3: Senior Congress leader and Leader of Opposition in Karnataka Assembly Siddaramaiah on Tuesday said that the party's protest will continue until the Speaker will allow them to discuss BJP MLA Basanagouda Patil Yathnal's recent comments on freedom fighter HS Doreswamy.

"Our protest in the well of state assembly will continue until Speaker allows us to discuss about Basanagouda Patil Yatnal," Siddaramaiah said.

Congress MLAs staged a protest in the Karnataka Assembly and entered the well demanding BJP MLA Basanagouda Patil Yathnal's apology for his 'Pakistani agent' remark.

Earlier, Congress leaders on February 26 staged a protest on the same issue in front of Mahatma Gandhi's statue at Vidhana Soudha.

Yathnal, on February 25, called Doreswamy a fake freedom fighter and a Pakistani agent while addressing the media. His comments triggered a controversy drawing sharp remarks from Congress and other parties.