Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
Comments
this boppa,vijay and naren dont hve the clear picture of this RSS and sangi guys so they brak from there side as they blive we all muslims are blongs to terrorist grp thn can they explain abt this RSS and sangi guys wht they are upto they want to divied the country or make a peace loving country. till now they divied the country by the name of religons .
this guys plan same policy which played by british divied and rule this sangi and RSS are born under there rules this sangis helped thm even nw they do the same.
comment #6 wht u written in last line of ur comment this shld b applied for the people inculding sangi and RSS guys aswel
dont blame we muslims we are very proud INDIAN MUSLIMS
we are proud to b an INDIAN more then u sangi and rss guys
and dont blame others first look into u wht gd deed hve u don till nw this for boppa,vijay and naren
Dear Naren
you dont have 70 virgins ...you have to taste only one that too Najas......... Brother Mustafa left this Duniya as Tippu did . and enjoying the favours from the creator . when he was hacked to death by cowards in the dark with the help of Coward fascist police . no problem we are borned for that we do not mourne but his family will curse you and you sangh .
Bopanna and vijay, every one will know your bulsh*t sangi parivar, you are sitting in and posting comments, stupid come out, you go and fight instead of sending poor in rana rang,
Naren, don't post your stupid and bulsh*t comments, come and fight face to face, Israel is your father country they also like you killing innocent people in back door.................ISIS and RSS is the same.....isis will not attack israel because its born from there only..
Ameen
Bupa, vijaya ..Mangalore ( Naren ignored ) ....Guys if u want to know the truth about this case contact the Vakil Dinesh Hegde Ulapady...before barking
So naren kotian,
Then start to attack anti nationalist first from mohan baaghwath, thogadia and so on means rss must be removed from the route. Then only brotherhood will remain in our great country India.
Jai Hind
same third rated guys rejoiced when muslim gangs killed prashanth poojari ... and yesterday one jihadi sitting in saudi , i think by name ahmed ... said next round will be of kiran shetty :) it shows ... and it says everything ... let it be ... i wish all murderers of prashanth poojari meets same end ,i pray to god ... israel policy follow madle beku ... when anti nationalist strike our eyes , we must strike their heart, kidneys ,eyes , liver ... legs and brain ... then only systerms will be back to normal .
Well said Bopanna....these people(so called peace lovers)they only know to blame RSS...
Dear Bopanna,
What about the gather during poor prashanth poojary funeral.All are belongs to anti India criminal rss group.
Karnataka police dept is well aware about all criminal groups. They never bow to any influence or to any muscle power. They kicked your dirty leader Togadia from airport back to his home town hell.
Jai Hind! Jai Karnataka!
Bopanna seems to have too much of hatred towards mulsims despite being and earning in an Islam country
If he hates muslims he has no moral rights to be, where he is currently
A theif's friend will be another theif only.
Let the police keep an eye on all these people who attended the event - a lot of terrorists there I am sure
Masha Allah great .Rest in peac my brother mustafa.
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