Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
Comments
i think Rahim Uchil is also on this dias and gave a speech supporting Nalin. Rahim will be next bjp mp. Is Rahim going to change his religion to save himself from the goondas of sangh parivar.
MP apina yogyete unda? Backlash malpavunait usshaar. Kelavu koditt malpader. Anda, Dever na backlash mokleg artha apuji.
whatever ...he will continue to win everytime he stands ... papa frustration nodree ... modle note ban mirchi ittange aagide ivakke ... next benami baratte , jothege zakir naik na mele multiple raids ... totall jihadi terrorism infrastructure collapsed for time being ... hawala ,hundi ge bidda hodetha dinda kundi ge kempu menasina kaayi ittida haage agide ... alvenree faizhal bhai....faizal bhai banree ,, johny walker kalsana ... athava ice cube kalsana ... swalpa ice cube mele kootu kolree ... hahaha
What about your team of 30 members who killed young Poojary in the mid of the road ???? why don't you talk ??? what about your team who killed Harish , innocent boy who was riding bike along with him muslim friend ???
Our sisters were raped and killed in Dharmastala and elsewhere why don't you protect for that poor death?
Awu ninna kannug thojujjja.. He is communal goonda not MP.
Try to make people together not to break??
Whoever attack or killed he should get severe punishment regardless of cast and community.
What about your team of 30 members who killed young Poojary in the mid of the road ???? why don't you talk ??? what about your team who killed Harish , innocent boy who was riding bike along with him muslim friend ???
Our sisters were raped and killed in Dharmastala and elsewhere why don't you protect for that poor death?
Awu ninna kannug thojujjja.. He is communal goonda not MP.
Try to make people together not to break??
Whoever attack or killed he should get severe punishment regardless of cast and community.
Hahahah..
Ulta chor kothwal ku daante!!!!
is he MP or goonda???? shame on such MPs....... no wonder he has proved that communal violence is created by his so called jumla party.....he must be arrested n thrown to bellary jail for threatening openly,,,,,,,
Totally rss want to do unrest in Karnataka. The elected representative from Mangalore don't know the value of Indian Constitution nor he know the meaning and responsibility of MP. Such a low grade fellow with worst attitude. His duty is to maintain law and order and to take care of the citizen l/o that he is with anti nations terror group. And threatening
to do bloodshed.
Seems his days r near.
Its shame for all those who voted Mr.Kateel, the MP who does not know even how to speak and the responsibility being an MP.
where is raheem uchil? he is missing??
Its time to wake up......you already deposited your money ...now barking ......poya ninna bandawal eethene......Pak flag hoisting...Go Kalla saganike ...Manipal Rape....Henda.....Gambling ...Pan......evishtu Bajrangdal amthhu chaddigala hanebaraha....saku nataka ....samanya janarannu maralu maduvudu nillisu
Please confirm retaliation on whom please clarify Mr kateel n group.
Why the district police dept kept quite on such terror groups and with their third rate leaders.
Hope state govt will take action on nalin. Elected people's representative's duty is to maintain law and order i/o that acting against the constitution is a Desh Drohi he is a terrorist.
This is the right time to take action on such criminals if not public mud stand together and retaliate.
Jai HIND!
lol... poor patient hindus sitting and watching leaders drama...
I think , nowadays , these leaders are not getting , as much support as they required....
nimage asttu desha bakthi iddre.. namm deshada gadi kaeeeri... illa andre yetto badwaru nam deshadalli ondu hottu outa illade saeeta iddare awarannu addru kapadi.. e reeti bogali yenu prayojane illa..
what abt attack on others? who will b responsible ?
People elected you as MP not to stage protest over unnecessary issue. Go to parliament and bring our 15 lack.
I think only Mangalorean cheddis never understand cheddi deception ???????
Jai sri ram .. He is right ...
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