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Washington, Jul 1: The United States has approved four coronavirus vaccine candidates for clinical trials, Food and Drug Administration (FDA) head Stephen Hahn told reporters.

"Four vaccines have been approved for moving into clinical trials... and another six are in the pipeline for us to review," Hahn said during a press briefing on Tuesday.

The US Administration launched in May Operation Warp Speed, a joint project of Health and Defense Departments, which aims to deliver 300 million doses of a vaccine for COVID-19 by January 2021.

The country's top pandemics expert Anthony Fauci warned on Tuesday, however, that there is no certainty the United States will be able to develop a vaccine against COVID-19 that works and will be safe.

Data on vaccine effectiveness, he added, may be available in the winter or early next year.

Canadian researchers are developing a DNA vaccine for SARS-CoV-2, the coronavirus that causes COVID-19 and has currently infected nearly 5,00,000 people worldwide and crippled the global economy.

Entos Pharmaceuticals, a health-care biotechnology company headed by a University of Alberta researchers, develop new therapeutic compounds using the company's proprietary drug-delivery platform and has begun manufacturing vaccine candidates against the novel coronavirus.

"Given the urgency of the situation, we can have a lead candidate vaccine within two months. Once we have that it's a race to get it into clinical trials," said John Lewis, CEO of Entos and a Professor at the University of Alberta in Canada.

Lewis said in comparison to a traditional vaccine, DNA-based vaccines hold several advantages.

Nucleic acids are introduced directly into the patient's own cells, causing them to make pieces of the virus--tricking the immune system into mounting a response without the full virus actually being present, the researcher said.

According to the company, the approach is recognised as being easier to move into large-scale manufacturing, offers improved vaccine stability and works without needing an infectious agent.

In the current absence of a vaccine for COVID-19, several companies around the world are mounting efforts to begin similar work.

The first clinical trial using a DNA-based vaccine developed by Moderna Inc.in the US on March 13.

Their approach allows for antibodies to be made in the human trial volunteers against a specific protein on the surface of the coronavirus that lets the virus enter human cells.

The hope is that the antibodies will stop the interaction.

Though this approach is designed to be effective against COVID-19 specifically, Lewis said Entos is taking a different tack.

The company plans to use plasmid DNA to amplify the production of key coronavirus surface and structural proteins with each injection, with an eye to the bigger picture.

"Many of the structural proteins in the virus are pretty well conserved across all the coronaviruses, including SARS and MERS," said Lewis.

"We're hoping that if we express more of the structural proteins that are common to most coronaviruses, we can inhibit the current COVID-19, and also potentially protect against all coronaviruses both past and future," Lewis added.

To move the project forward quickly, the company is seeking financial support from both provincial and federal levels of government.

"We have the opportunity to save a lot of lives, and I think it's really upon us and governments to find solutions for that," Lewis said.

London, Apr 12: British Prime Minister Boris Johnson has thanked the medics and staff of the state-funded National Health Service (NHS) for saving his life after he tested positive for the coronavirus, saying he owed them his life.

In his first public statement since being moved out of the intensive care at St. Thomas’ Hospital in London on Saturday, the 55-year-old Johnson said, “I can't thank them enough, I owe them my life.”

Downing Street has said that Johnson, who completes a week in hospital on Sunday after being shifted there with persistent COVID-19 symptoms, continues to make “very good progress” while on the ward.

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He has been able to take short walks as his doctors monitor his recovery after being moved out of the intensive care and has been watching films and doing puzzles in his hospital bed.

Johnson's fiancee Carrie Symonds, who is pregnant with their first child, is said to have sent him letters and baby scans to lift his spirits during his time in the hospital.

Thousands of get-well-soon cards have also poured in for the prime minister since he went into self-isolation after testing positive for coronavirus over two weeks ago.

Asked about plans for his return to work, UK Home Secretary Priti Patel said on Saturday that the UK PM needed "time and space to rest, recuperate and recover".

The Indian-origin Cabinet minister, who led the daily Downing Street update on the pandemic on Saturday, revealed that the UK had recorded 917 new coronavirus deaths, taking the total deaths in the country to 9,875.

According to the Johns Hopkins University data, the country has nearly 80,000 coronavirus cases.

Patel urged people to stay at home over the Easter weekend to curb the spread of the virus, despite warm and sunny weather across parts of the UK.

“We have given the police powers to enforce the necessary measures we have put in place, including through enforcement fines," said Patel.

"If you don't play your part... our selfless police will be unafraid to act. You will be endangering the lives of your own family, friends and loved ones," she said.

Meanwhile, an Easter message posted on the official 10 Downing Street Twitter account on behalf of the prime minister also urged people to stay at home to save lives.

It read: “Wishing everyone a very happy Easter from Downing Street.

“This year across the country churches will remain closed, and families will spend the day apart. But by staying home, remember, you are protecting the NHS and saving lives.”