Food-borne bacteria up miscarriage risk early in pregnancy

February 22, 2017

Feb 22: Listeria, a common food-borne bacterium, may pose a greater risk of miscarriage in the early stages of pregnancy than previously thought, says a study.

pregnancy“For many years, listeria has been associated with adverse outcomes in pregnancy, but particularly at the end of pregnancy,” said one of the researchers Ted Golos, Professor at University of Wisconsin-Madison in the US.

“What wasn’t known with much clarity before this study is that it appears it’s a severe risk factor in early pregnancy,” Golos said.

Pregnant women are warned to avoid many of the foods -- among them unpasteurised milk and soft cheese, raw sprouts, melon and deli meats not carefully handled -- that can harbour listeria, because the bacterium is known to cause miscarriage and still-birth, and spur premature labour.

But when it occurs, listeria infection in pregnancy may go unnoticed.

For the study, four pregnant rhesus macaques at the Wisconsin National Primate Research Centre were fed doses of the listeria comparable to what one might encounter in contaminated food.

None of the monkeys showed obvious signs of infection before their pregnancies came to abrupt ends, according to the results published in the journal mBio.

But in tissue samples taken after each monkey experienced intrauterine fetal death, the researchers found that listeria had invaded the placenta -- the connection between the mother-to-be and the foetus, which usually prevents transmission of bacteria -- as well as the endometrium, the lining of the uterus.

The researchers believe the inflammation caused by the maternal immune response to the fast-moving listeria also affects the placenta, keeping it from protecting the foetus.

The results suggest listeria (and perhaps other pathogens) may be the culprit in some miscarriages that usually go without diagnosed cause.

“There are effective antibiotics available. It is treatable,” said lead author of the study Bryce Wolfe, a graduate student at University of Wisconsin-Madison.

“The issue is that because it’s asymptomatic, the foetus may be infected by the time anyone realises the mother was infected,” Wolfe explained.

Comments

Wellspringivfs…
 - 
Thursday, 8 Feb 2018

Great post. Pregnant women are warned to avoid some foods such as unpasteurized milk, raw meat, and sprouts etc. because that may harbor listeria which may cause pregnancy complications such as miscarriage and stillbirth. http://www.wellspringivfsurrogacy.com/

Leesa
 - 
Thursday, 4 Jan 2018

Nice article. Listeria, a common food-borne bacterium increases the risk of miscarriage in early stages of pregnancy. It is important to follow the food safety measures. Listeria infection in pregnancy often goes unnoticed because of lack of awareness.  Expecting mothers should strictly avoid the food intake which contains listeria, as it may lead to miscarriage. To know more about pregnancy visit http://www.progenesisivf.com/

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Agencies
May 17,2020

Geneva, May 17: Spraying disinfectant on the streets, as practised in some countries, does not eliminate the new coronavirus and even poses a health risk, the World Health Organization (WHO) warned on Saturday.

In a document on cleaning and disinfecting surfaces as part of the response to the virus, the WHO says spraying can be ineffective. "Spraying or fumigation of outdoor spaces, such as streets or marketplaces, is... not recommended to kill the Covid-19 virus or other pathogens because disinfectant is inactivated by dirt and debris," explains the WHO.

"Even in the absence of organic matter, chemical spraying is unlikely to adequately cover all surfaces for the duration of the required contact time needed to inactivate pathogens." The WHO said that streets and pavements are not considered as "reservoirs of infection" of Covid-19, adding that spraying disinfectants, even outside, can be "dangerous for human health".

The document also stresses that spraying individuals with disinfectants is "not recommended under any circumstances".

"This could be physically and psychologically harmful and would not reduce an infected person's ability to spread the virus through droplets or contact," said the document.

Spraying chlorine or other toxic chemicals on people can cause eye and skin irritation, bronchospasm and gastrointestinal effects, it adds.

The organisation is also warning against the systematic spraying and fumigating of disinfectants on to surfaces in indoor spaces, citing a study that has shown it to be ineffective outside direct spraying areas.

"If disinfectants are to be applied, this should be done with a cloth or wipe that has been soaked in disinfectant," it says.

The SARS-CoV-2 virus, the cause of the pandemic that has killed more than 300,000 people worldwide since its appearance in late December in China, can attach itself to surfaces and objects.

However, no precise information is currently available for the period during which the viruses remain infectious on the various surfaces.

Studies have shown that the virus can stay on several types of surfaces for several days. However, these maximum durations are only theoretical because they are recorded under laboratory conditions and should be "interpreted with caution" in the real-world environment.

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Agencies
February 6,2020

Researchers have found the rates of lung cancer are higher in young women than men.

The study, published in the journal Pediatrics, examined lung cancer rates in young adults in 40 countries across five continents and uncovered a trend of higher lung cancer rates in women compared with men in recent years.

The emerging trend was widespread, affecting countries across varied geographic locations and income levels.

The changes appeared to be driven by a rising rate of adenocarcinoma lung cancer among women, said the study researchers from University of Calgary in Canada.

Lung cancer rates have been higher among men than women because men started smoking in large numbers earlier and smoked at higher rates; however, recent studies have reported converging lung cancer incidence rates between sexes.

Among men, age specific lung cancer incidence rates generally decreased in all countries, while in women the rates varied across countries with the trends in most countries stable or declining, albeit at a slower pace compared to those in men.

For the findings, lung and bronchial cancer cases between 30-64 age group from 1993-2012 were extracted from cancer incidence in five continents.

The study found the higher emerging rates of lung cancer in young women compared to young men.

According to the researchers, future studies are needed to identify reasons for the elevated incidence of lung cancer among young women.

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Agencies
June 4,2020

The World Health Organisation on Wednesday said that anti-malarial drug hydroxychloroquine (HCQ) will return to the solidarity trial for the potential treatment of coronavirus disease.

At a press conference in the WHO headquarters in Geneva, Director General Tedros Adhanom Ghebreyesus said: "On the basis of the available mortality data, the members of the committee recommended that there are no reasons to modify the trial protocol. The Executive Group received this recommendation and endorsed continuation of all arms of the solidarity trial, including hydroxychloroquine."

The world health body had temporarily suspended the usage of HCQ from the solidarity trial for coronavirus treatment on May 25 soon after a study published in one of the most reliable medical journals, which had suggested that the drug could cause more fatalities among COVID-19 patients.

However, the WHO chief said that the decision was taken as a precaution while the safety data was reviewed.

Ghebreyesus also said that the Data Safety and Monitoring Committee will continue to closely monitor the safety of all therapeutics being tested in the solidarity trial.

"So far, more than 3,500 patients have been recruited in 35 countries. WHO is committed to accelerating the development of effective therapeutics, vaccines and diagnostics as part of our commitment to serving the world with science, solutions and solidarity," he said.

Soon after HCQ was suspended from the trial, the Indian government had said that the antimalarial drug has been known for its benefits for a long time and its usage will be continued on the frontline workers, including police and healthcare professionals, as prophylaxis. The government had also said that studies were being conducted and the drug would be included in the clinical trial also for the treatment of coronavirus disease.

US President Donald Trump also had strongly advocated the use of HCQ and called it a "game-changer". He went to the extent of saying that he had taken the medicine.

Launched by WHO and partners, solidarity trial is an international clinical trial to find an effective treatment for COVID-19, including drugs to slow the progression of the disease or improve survival. The trial, which enrols patients from different countries, "will compare four treatment options against standard of care to assess their relative effectiveness against COVID-19", said WHO. 

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