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Mumbai, Mar 25: Filmmakers and actors, including Karan Johar, Taapsee Pannu and Ayushmann Khurrana, have pledged their support to a new initiative aimed at supporting the daily wage-earners who have been severely affected by the lockdown imposed to combat coronavirus.
The country is witnessing a 21-day lockdown, as announced by Prime Minister Narendra Modi, to contain the spread of the virus, which has claimed the lives of over 20,000 people globally.

The initiative, I Stand With Humanity, started by organisations -- the International Association for Human Values, the Art of Living Foundation and the Indian Film and TV Industry, will provide families of daily wage workers with 10 days of essential food supplies.

"I pledge to contribute and support this initiative! This is a situation that needs all our help, love, care and support," Karan posted on Twitter.

Taapsee said everyone must come forward to help the daily wage workers.

"This one for the daily wage workers. Because we need to do our bit for the ones who work with/for us. If not corona, lack of basic food might take them down. Let's help them to get through this," the actor wrote.

Ayushmann described the initiative as "truly noble".

"I vow to support this and contribute. India and Indians are under threat and each one of us have the power to make a difference. Let's support and care for each other as much as we can in this time of crisis. #Istandwithhumanity," he tweeted.

Kiara Advani and Rakul Preet Singh also pledged to contribute towards the initiative.

"Let's contribute! While some of us are safe at home, we can help those struggling right now... donate," Kiara said.

Rakul tweeted, "I support this noble initiative. Happy to contribute for this humanitarian cause. While staying safe at home, I urge every one else also to contribute online."

Actor Varun Sharma said, "I pledge to contribute & support this initiative #iStandWithHumanity"

"In times like these, we need to step up for the ones in need. I'm happy to contribute for this humanitarian cause. And guys whoever can help, you all can also contribute online," actor Sidharth Malhotra tweeted.

Filmmaker Nitesh Tiwari wrote, "There are a lot of daily wage earners who need our help during this tough time. Please help as much as you can. Here's the link to contribute online."

Actor Bhumi Pednekar said it was important to get together and help those who are "vulnerable and in need".

Actor Dia Mirza said, "We are in this together. YES we will help #DailyWageEarners get through this with hope and dignity. I am contributing to this effort and I hope many others in our fraternity will do as well."

Filmmakers Aanand L Rai and Sanjay Gupta have also backed the cause.

"One of the greatest gift a person can give another, is support. I whole heartily support this noble initiative. While staying safe at home, I urge every one else also to contribute online," Aanand tweeted.

Gupta called upon the public to help the daily wage-earners through the initiative.

On March 18, the Producers Guild of India had announced that they have set up a relief fund for daily wage-earners impacted by the shutdown of film, television and web productions amid coronavirus pandemic.

Their decision came after many filmmakers, including Sudhir Mishra, Vikramaditya Motwane and Anurag Kashyap, raised concerns over the impact of shutdown on the daily wage workers.

South star Pawan Kalyan announced on Twitter that he will donate Rs 1 crore to PM relief fund.

B N Tiwari, President of Federation of Western India Cine Employees (FWICE), however, claimed there has been no help from Bollywood personalities or the Producers Guild of India so far.

"In the South, Rajinikanth has donated Rs 50 lakh which is a great thing. But here, we haven't received any call or help from anyone from Bollywood yet."

"There is one production company called Frames that produces TV shows, they have given ration worth Rs 25 lakh but it is stuck at Navi Mumbai and we haven't been able to give that to workers as they can't come here. We are toying with the idea of taking help of police authorities to give the ration to the workers," Tiwari told news agency.

Kochi, Mar 30: Kerala High Court, while hearing a petition filed against Karnataka's decision to block the border with Kerala, on Monday said that no lives should not be lost in the name of fighting coronavirus.

Kerala High Court also said that "the current problem should be resolved amicably. Both the Union government and the Karnataka government should rise to the occasion."
The Central government has informed Kerala High Court that the movement of goods and medical services qualify under essential services, which is permitted despite the lockdown, and added that directions have been issued to give priority to the movement of such goods and services.
Meanwhile, the Karnataka government has sought a day's time to clarify their stand.

The matter will be taken up for further hearing via video conference tomorrow.
Kerala government has submitted that the action of Karnataka government to close the border is illegal as all the national highways in the country come under the jurisdiction of the National Highway Authority.

Meanwhile, Congress MP Rajmohan Unnithan has also approached the Supreme Court seeking directions to open the Karnataka-Kerala border to allow movement of ambulances and other emergency vehicles for the transport of essential items to Kerala.

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer.