Battle for Mangaluru: Khader, Santosh, Ashraf field six common questions

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

The carnage or to put it more precisely the anti Muslim violence in Delhi (February-March 2020) has shaken us all. Analysts are burning midnight oil yet again to understand the deeper causative factors of the same. 

One of the neglected aspects of analysis of communal violence has been the one related to prevalent factor of Caste in Indian society. Caste is inherent in the scriptures called as Hindu scriptures; caste has been the rigid frame work of Hindu society, which has also penetrated into other religious communities in India.

The deeper connection between Hindu nationalism or Hindutva and caste has been explored somewhat but not too many studies have taken up the relationship between the communal violence and caste in India.

Suraj Yengde (IE, Delhi Pogrom is an attempt to Divert attention from Government’s Failures, March 8, 2020) makes some points on this issue. Yengde points out, “Many are still downplaying the Delhi riot as an affliction of Hindutva or Hindu-Muslim binaries. It is neither. It is not religious but caste tensions that encourage such treacherous acts.”    

He quotes from the Gujarat activist Raju Solanki, “in the 2002 Godhra riots there were 2,945 arrests in Ahmadabad. Of these, 1,577 were Hindus and 1,368 Muslims. Among the Hindus arrested, 797 were OBCs, 747 Dalits, 19 Patels, two Baniyas, and two Brahmins. The upper castes became MLAs, the rest were jailed. Also, it is not an accident that Dalits constitute nearly 22% of the total arrests in India; Adivasis 11%, Muslims 20% and OBCs 31%. More than 55% of under trials also come from the same communities (NCRB 2015).”

While this data is on the dot it must be stated that while caste has lot of role in the emergence of politics of Hindutva, in the resultant violence the primary focus has been religion, here caste plays a role which is secondary in some ways.

To trace the outline of the Hindu nationalism’s prime mover RSS; one can definitely say that its formation and rise is primarily due to the rising caste consciousness and the beginnings of struggles aimed at injustices due to the caste Varna System. While Hindu Mahasabha was already on the scene as parallel and opposite to the Muslim League, these formations initially had only Kings and landlords. Later these formations were joined in by some elite, affluent sections of society.

RSS in particular was a response to the ground level changes resulting in coming up of low caste/average people in social and political space. It was the non-cooperation movement led by Gandhi and then the non Brahman movement in Nagpur-Vidarbha area which disturbed the Brahmanical sections, supported by landlord-kings, to take up the agenda of Hindu nation. The core articulation of Hindutva politics was to present the glorious ancient times, when Manu Smriti’s laws ruled the roost. These were getting a jolt now as the efforts of Joti Rao Phule and later the campaigns of Ambedkar started empowering the downtrodden dalits. This was a serious threat to Brahmanical system.

While this was the core an external threat was to be created to ‘unify’ Hindu society. And here the Muslims, Muslim Kings rule came in as handy. It is this anti Muslim tirade and actions which was the frontage for Hindutva, while the anti dalit-agenda was the real underlying motive. The whole of Shakha (RSS branches) baudhiks (intellectual sessions) were structured around this. The promotion of communal historiography, the hatred for Muslims was the visible part of RSS training, while glorification of past is the fulcrum which in a way is the code language for retaining the hierarchy of caste and also of gender.

Practically also if we see the strengthening of Hindutva began on the issue of a Muslim king destroying the temple of the birth place of Lord Ram, this campaign got its vitriol after the implementation of Mandal Commission in 1990. The anti Muslim Hate and promotion of values of caste and gender hierarchy are synthesized by Hindutva politics. That’s as far as the political agenda of Hindu nationalism goes. As far as communal violence is concerned, it has been an anti Muslim work through and through. All the statistics shows that victims of communal violence are primarily Muslims, around 80% of victims being Muslims. These Muslims do come from all sections of Muslims, more from the poor.

The caste comes into operation in the mechanism of riot production. Hindutva politics, through its extensive network has been working relentlessly among dalits. The recent book by Bhanwar Meghwanshi, “I was a Kar Sevak”, brilliantly describes the mechanism of co-opting dalits into the agenda of sectarian politics. RSS has floated innumerable organizations, like Samajik Samrasta Manch, which work among dalits to promote Brahmanical values and to integrate dalits into the scheme of Hindutva politics. They are made to act as foot soldiers of Hindu nationalist politics. Those who spread hate through indoctrination and propaganda are safe in their cozy houses or offices while the poor dalits are made to soil their hands with the blood of religious minorities.

The face of Gujarat violence, Ashok Mochi, now talks of dalit-Muslim unity. The data compiled by Raju Solanki and quoted by Yengde is the norm in the cases of violence in India. Those who are incited, those who are later charged with violence are not the ones who give donations to RSS or support its various activities. Most of these do come from the sections of indoctrinated youth from downtrodden communities.

Yengde has done a valuable job in drawing our attention to the role of caste in communal violence; the problem with his thesis is the undermining the role of ‘Hate against religious minorities’, which is the base on which the violence is orchestrated. The extent and degree of indoctrination done through shakhas is very powerful and effective. This can gauzed from the experiences of the likes of Bhanwar Meghwanshi, who tells us the difficulties he had to face to come to grips of reality of caste while overcoming the RSS propaganda.

Mangaluru, Mar 30: In continuing cases of tipplers in the southern states ending their lives due to non-availability of liquor during the lockdown, two men committed suicide in Karnataka's Dakshina Kannada district.

The two suicides were reported in Kadaba taluk on Saturday, police said.

Tomy Thomas (50), a rubber tapping labourer in an estate at Kutrupadi village of the taluk, was found hanging at his rented house on Saturday. Thomas, a native of Kottayam in Kerala, had joined at the estate here a month ago.

Local people said he was desperately moving around in the last few days asking about places where he can get liquor. He had also not reported to work in these days. The body has been kept at the mortuary of a hospital at Deralakatte.

In another incident, a 70-year old man, belonging to Kodimbala village in the taluk, allegedly hanged himself from the branch of a tree near his house at Nakur.

The deceased has been identified as Thomas, who had left his family here 30 years ago and had been working in Kerala. He had returned here only a few years back.

Sources said Thomas, an alcohol addict, was having health problems related to withdrawal. He has been living on pavements at Kadaba without going home.

Kadaba police has registered cases in connection with the two incidents.

Incidents of tipplers committing suicide have been reported in Kerala and Telangana in the past few days. Two men ended their lives in Kerala today while a 50-year old daily wage worker jumped to death from a building in Hyderabad on Friday.