Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer.
Comments
I was surprised with these people who run educational institutions since long, and the management not understand the rights of Muslims women, that is also simple wearing scarf as it is a moral and religious rightrs of muslim women,and girls, it covers the chastity and aura of a girl ,a mother , and as well all women, but why these nuns are discriminating with muslim community only, by the way why they cannot work without their scrafs inside school or college, Every muslim women is a spiritually religious to wear scraf or cover the chastity with the scarf ..complare to few nuns only wear scarfs since it is their religious rights.
I am asking the management of college to settle the matter peacefully .
No one is abusing her, but for the decision what she has taken is just showing her personality whether she is a angel or simply a common woman who is making a religious chaos between two Community. Respect each others community is what we learn from from Masjid and Church. But here this is going some other way.need to stop before the situation is worsened
I request all the muslim students to wear the same dress what the madam is wearing - problem solved..
Angle......... my foot!!!...if man can become angle then i would have been the first...
Shocked to read brainless comments from Muslims. Muslims cannot build an institution like St Agnes College in Mangalore. But they talk about their rights in Christian and Hindu managed colleges. What a tragedy. May Allah grant good sense to Muslims so that they realize their foolishness.
Never expected such a drity mind set opinion form a religious preacher. She can wear full hijab and Muslim students not permitted. It is well clear to understand what time of human being she is and what is her intention.
Check her passport how many times she visited isreal
Dear Management
When you are implementing any rule's, it should be such that you should be following it. If your principal herself is wearing then how ethical is that to stop the students wearing it.
Hijab is for to cover the modesty and not for exposing.!! Please respect each others propsective.
Sr Dr M Jeswina AC is not a divine woman. She is an angel. Those who mock her must be extremists or anti-social elements.
One more Threat for Indian Democracy by the Principal of St. Agnes College Mangalore, Sr Dr M Jeswina AC.
If the Principal can wear the Scarf, then why Shouldn’t the Students.
Again why its Double standard and what is the Method behind this policy.
Common, once again we all indian’s should BIGOT this policy of St Agnes College Mangalore.
i donno hu ur. but i felt ur comment on the issue of head scarf as funny. as hijab for men and women is farl or compulsory den u need to follow it. to be a citizen of a country u must follow the rules of that country. similarly if u want to be a muslim u need to follow the rules of islam. otherwise u r not called one.u can say that islam is in heart need not show in hijab. when imaan is in heart then definitly hijab will be der otherwise u need to check ur imaan not alter the rules of islam.
Principal Mam can wear fully covered headscarf. But students (muslim) can't...
Dear All
this is the height of hypochracy ..... she herself opt for it , and say you dont wear it ???// in Quran its mentioned ..''Do not preach unless you follow it ''
Dear Sister Dr. Jeswina
How can You prevent and take this decision being in a headscarf? Interestingly you preach this and practice proudly and roam around the world wearing such dress code which you and your institutions are opposing other community. May I ask you on behalf of society with all due respect to your valuable service to the education, what kind of justification you are putting forward to media and seeing students attend classes ignoring their constitutional demand. Dear Sister, will you implement and make it mandatory same rules for students who are wearing a similar dress which you are into? If not this approach will be called communalism or fascism (Sorry for using such words).
Dear Principal, Institutions are not at all allowed to restrict a students religious practice at any place inside the campus. In front of the constitution your college rules will fall down and your college rules should be modified. Look at the hypocrisy you are playing with the students. You will enter the class with your scarf on. And you want a particular community student to remove it? What kind of justice it is.No education institutions are even allowed to impose uniform system for students. We condemn your act. Just don't drag this issue more, please behave mature
Catholic run schools and colleges always do like this.
I am not sure whether there is male teacher in this college, if yes, then the women have right to observe hijab inside the classroom as well. No rules is bigger than the personal right guaranteed to individuals living in India. If this principal mam have right to observe her personal hijab inside her cabin, then Muslim women also should be given their rights.
easy solution, let Muslim students accepts the principal madam dress code, in this matter, let it teacher will be role model for students, accept it
dear college management and student,
as soon as i saw people discussing and sharing the views regarding the ban of women scarf in the college auditorium, i too wants to share some views and ideas related to this. as far as college rules and regulation is concern ban of scarf is acceptable. but if we follow the rules and regulation of my lord it is unacceptable.
student should first contact pricipal regarding whatever issues they. and it the liability of the management to solve the issue in favour of the student because whatever issue they are raising it is the issue to uplift the women rather degrading. hoping the maangemnt to solve the issue in favour of student.
In Islam, men have an obligation to God and to women to observe hijab. I imagine a conversation between someone teaching the Quran and a guy as follows:
Teacher: Don’t stare at women.
Guy: But she’s wearing revealing clothing!
Teacher: Why are you staring? Stop.
Guy: But it’s revealing.
Teacher: Why-are-you-staring?
Guy: Uh…
It’s that simple.
If a guy chooses to accept Islam, Islam says he must observe hijab. The Prophet Muhammad’s directives further affirm this view. He admonished men, “Be chaste yourselves, and women will be chaste as well,” again putting the primary burden of hijab on men.
This point was again illustrated when the Prophet rode with his companion Al Fadl bin Abbas. A woman described as strikingly beautiful approached the Prophet to seek his guidance on some religious matters. Al Fadl began to stare at her because of her beauty.
Noting this, the Prophet Muhammad did not scold the woman for dressing immodestly or revealing her beauty. Instead, he “reached his hand backwards, catching Al Fadl’s chin, and turned his face to the other side so that he would not gaze at her”. Thus, the Prophet Muhammad once more established that the primary burden to observe hijab rests on men.
Ughhhhh. Individual choice yes. But college has certain rules. You don't want to follow the rules, you don't join that particular college. Also, Islam is a very beautiful religion. Let's not make it all about the Hijab.
All students (irrespective of religion) should obey collage or school rule.
missionary school management are allowing sisters to wear their dress similar to Principal dress but they are restricted to hijab.
There is no comparison between student and principle..
Rules are only followed by the students.
Prici mam… whatever u are wearing is a perfect Hijab in Islam. Kindly allow Muslim girls also to wear the same in classroom.
Hahahahhah.. what a pic!!!! She can wear headscarf but Muslim students can’t wear!!!
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