SFI leader stabbed to death on college campus in Kerala

Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Mysuru, Jan 21: South Indian actor Rashmika Mandanna, whose house was raided recently by IT sleuths, appeared for an inquiry along with her father Mr Madan Mandanna, here on Tuesday.

She arrived at the office of Principal Commissioner for IT, at Nazarbad, in the city. She was accompanied by nine persons, including auditors and accountants, who carried two backpacks and a kitbag.

Mr Madan mandanna said, "the IT officials have sought some documents and we are here to submit them."

Bengaluru, Mar 27: Karnataka has so far witnessed 62 Covid-19 positive cases including 3 deaths and five discharges, according to mid-day bulletin released by the Department of Health and Family Welfare.

The state on Friday witnessed a sudden spike in the number of Covid-19 cases with the officials confirming seven new positive cases overnight (26 March 5:00 pm to 27 March 8:00 am) across the state including a 10-month-old baby boy becoming the youngest Covid-19 patient in Karnataka and second youngest patient in India after 8-month-old baby in Jammu and Kashmir.

According to mid-day bulletin released by the Department of Health and Family Welfare on Friday, Karnataka witnessed 62 Covid-19 positive cases including 3 deaths and five discharges. The 10-month-old baby (P56) even though had no travel history to any of the Covid-19 affected countries, officials revealed that the family members had taken the baby to Kerala and six primary contacts have been established and put under home quarantine.

This apart, a 20-year-old male (P57) who returned from Colombo, a 25-year-old female (P58) who returned from London have also been tested positive for Covid-19. Further, a 35-year-old female (P59) and 33-year-old female (P61) said to be the primary contacts of P25 (House Maid) have also been tested positive according to the officials

Besides, a 60-year-old male (P60) who returned to Sira in Tumakuru by train from New Delhi died on Friday morning also tested positive. His primary contacts, including health care professionals have been put under house quarantine. According to officials a 22-year-old male (P62) from Uttara Kannada with travel history to Dubai has also been tested positive for Covid 19 on Friday.

According to bulletin, all the patients barring P60 are being treated at designated isolation hospitals in Mangaluru, Bengaluru and Uttara Kannada. In the meantime, P1 and P3 from Bengaluru have been discharged from RGICD, according to officials.