In meeting with Malaysian PM, Modi raises issue of Dr Zakir Naik’s extradition

Canadian researchers are developing a DNA vaccine for SARS-CoV-2, the coronavirus that causes COVID-19 and has currently infected nearly 5,00,000 people worldwide and crippled the global economy.

Entos Pharmaceuticals, a health-care biotechnology company headed by a University of Alberta researchers, develop new therapeutic compounds using the company's proprietary drug-delivery platform and has begun manufacturing vaccine candidates against the novel coronavirus.

"Given the urgency of the situation, we can have a lead candidate vaccine within two months. Once we have that it's a race to get it into clinical trials," said John Lewis, CEO of Entos and a Professor at the University of Alberta in Canada.

Lewis said in comparison to a traditional vaccine, DNA-based vaccines hold several advantages.

Nucleic acids are introduced directly into the patient's own cells, causing them to make pieces of the virus--tricking the immune system into mounting a response without the full virus actually being present, the researcher said.

According to the company, the approach is recognised as being easier to move into large-scale manufacturing, offers improved vaccine stability and works without needing an infectious agent.

In the current absence of a vaccine for COVID-19, several companies around the world are mounting efforts to begin similar work.

The first clinical trial using a DNA-based vaccine developed by Moderna Inc.in the US on March 13.

Their approach allows for antibodies to be made in the human trial volunteers against a specific protein on the surface of the coronavirus that lets the virus enter human cells.

The hope is that the antibodies will stop the interaction.

Though this approach is designed to be effective against COVID-19 specifically, Lewis said Entos is taking a different tack.

The company plans to use plasmid DNA to amplify the production of key coronavirus surface and structural proteins with each injection, with an eye to the bigger picture.

"Many of the structural proteins in the virus are pretty well conserved across all the coronaviruses, including SARS and MERS," said Lewis.

"We're hoping that if we express more of the structural proteins that are common to most coronaviruses, we can inhibit the current COVID-19, and also potentially protect against all coronaviruses both past and future," Lewis added.

To move the project forward quickly, the company is seeking financial support from both provincial and federal levels of government.

"We have the opportunity to save a lot of lives, and I think it's really upon us and governments to find solutions for that," Lewis said.

Mangaluru: The first-of-its kind Beach Zumba event organized by Veekshitha Arasa on January 26th at Panambur Beach, Mangaluru attracted huge crowd and entertained the masses. Thousands of people who visited the beach last Sunday evening witnessed and danced along with the talented Zumba instructors from Bengaluru and Mangaluru. The show lasted for almost two hours.

The programme was organized by Veekshitha Arasa in association with Panambur Beach Tourism with the cooperation of Panambur Police and sponsorship of AJ Hospital & Research Centre, APD Foundation and SS Arrangers & Caterers.

Panambur Beach Tourism CEO Yatish Baikampady, APD Foundation Trustee Abdullah Rehman and Santhosh Kumar from SS Arrangers and others flagged off the event by releasing saffron, white and green balloons (the colours of Indian tricolor) to mark the nation’s Republic Day. Panambur beach police officials too participated in the inauguration. Veekshitha Arasa’s husband Rohan Lobo, Veekshitha’s parents Bhaskar Arasa and Geetha B Arasa too joined in.

This was done with the message ‘Let the love for health and fitness fly high among the citizens much like the soaring spirit of patriotism’. Speaking on the occasion, Veekshitha said that it was her dream to conduct a Zumba event in the city. “This is my small attempt at promoting fitness among the citizens of Mangaluru. There should be more such events,” she said.

Meenal Dubey, Ashwitha Shetty, Vishal Rai, Aishwarya, Namratha Shekar, Shruthi Keerthiraj, Vinayak Acharya, Kavitha Manish and Urmi were some of the enthusiastic Zumba instructors who performed with Veekshitha.

RJ Nayana and Saravanan Govindaswamy compered the event.

London, Jun 25: British Prime Minister Boris Johnson has called on India and China to engage in dialogue to sort out their border issues as he described the escalation in eastern Ladakh as "a very serious and worrying situation" which the UK is closely monitoring.

The first official statement of Mr Johnson came during his weekly Prime Minister's Questions (PMQs) in the House of Commons on Wednesday.

Responding to Conservative Party MP Flick Drummond on the implications for British interests of a dispute between a "Commonwealth member and the world's largest democracy on the one side, and a state that challenges our notion of democracy on the other," he described the escalation in eastern Ladakh as "a very serious and worrying situation", which the UK is "monitoring closely".

"Perhaps the best thing I can say... is that we are encouraging both parties to engage in dialogue on the issues on the border and sort it out between them," the Prime Minister said.

In a statement in New Delhi on Wednesday, the Ministry of External Affairs (MEA) said India and China have agreed that expeditious implementation of the previously agreed understanding on disengagement of troops from standoff points in eastern Ladakh would help ensure peace and tranquillity in the border areas.

During the diplomatic talks between India and China, the situation in the region was discussed in detail and the Indian side conveyed its concerns over the violent face-off in Galwan Valley on June 15. Twenty Indian Army personnel were killed in the clash. There were reports of several casualties for the Chinese army too, but China hasn't declared any official number yet.

The talks were held in the midst of escalating tension between the two countries following the violent clashes in Galwan Valley on June 15.

The Indian and Chinese armies are engaged in the standoff in Pangong Tso, Galwan Valley, Demchok and Daulat Beg Oldie in eastern Ladakh. A sizable number of Chinese Army personnel even transgressed into the Indian side of the Line of Actual Control in several areas including Pangong Tso.