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May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.

According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.

"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.

They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.

Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.

"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.

"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.

In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.

"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.

The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.

These children were then confirmed to have COVID-19.

While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.

Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.

According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.

"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.

Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.

While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.

However, he cautioned that more research is needed to confirm their findings.

"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.

Bengaluru, Apr 11:  Amid nationwide lockdown in the wake of COVID-19, former Karnataka Chief Minister HD Kumaraswamy on Saturday urged the state government to announce a relief package for farmers.

Prime Minister Narendra Modi on Saturday held a video conference with Chief Ministers.

Taking to Twitter, Kumaraswamy wrote, "As the lock down continues, what action plan does the government have to tackle the challenges of ensuring marketing channels for farm produce with timely transport and ensuring uninterrupted supply of essential groceries to towns and cities?"

He later asked the government to act "swiftly and effectively".

"On one hand we see farmers throwing their produce in despair and losing their livelihoods. On the other hand supplies to towns are depleting. This is threatening both lives and livelihoods. The government must act swiftly and effectively," Kumaraswamy tweeted.

"I urge the state government to immediately announce relief package to farmers by way of direct benefit transfer mechanism and purchase all the agricultural produce so as to avoid farmer suicides," he added.

With 40 deaths and 1,035 new COVID-19 cases in the last 24 hours, India on Saturday witnessed a sharpest ever increase in coronavirus cases, taking the tally of the infected people in the country to 7,447, according to the Ministry of Health and Family Welfare.

Bengaluru, Jul 20: Karnataka on Monday reported 3,648 COVID-19 cases taking the tally to 67,420, informed the state health department.

According to a bulletin issued by the department, the state recorded 72 more deaths due to COVID-19 with the toll at 1,403 while six patients who tested positive for the infection have died due to non-COVID causes, as of Monday.

There are 42,216 active cases in the state.
As many as 730 patients were discharged today, taking the total discharged patients to 23,795.
Bengaluru recorded the highest number of cases and deaths today at 1,452 and 31, respectively, informed the state health department.

India's COVID-19 case tally crossed the 11-lakh mark with the highest single-day spike of 40,425 new cases and 681 deaths reported in the last 24 hours, said the Union Health and Family Welfare Ministry on Monday.

The total cases in the country now stand at 1,118,043 while the death toll is 27,497.

The ministry said the total number of cases include 390,459 active cases and 700,087 cured/discharged/migrated.