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Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Bengaluru, Jan 8: CISF personnel at Bengaluru airport on Wednesday detained two persons after they found two live bullets in their baggage during the routine inspection.

The detained person, said to be of a Mangaluru origin who arrived at the airport on Wednesday morning has claimed to be serving the American military. His mother who had arrived with him too has been taken into custody.

According to officials during the questioning, the man said that he was on a leave and that as he had hurriedly packed his belongings at the last minute there was a possibility that the bullets might have fallen into his bag mistakenly.

Mangalore, May 2: More than 500 families received ration kits in a distribution drive conducted by St Agnes College in outskirts of Mangaluru on Wednesday.

Since the lockdown was announced, the management, staff and alumni of St Agnes College are playing an active role in ensuring no one is deprived of food and essentials during these challenging pandemic times.

The College as part of its Agnes towards Community (ATC) programme had adopted villages such as Munnur, Harekala, Amlamogaru, Someshwara and Pavur. Various development drives are conducted in these villages by the staff and students. However, due to the COVID-19 lockdown, the activities undertaken in these villages were kept on hold.

The College recently received information from its network that several families in these villages are struggling for food and essentials.

The College management in association with its alumni and well-wishers took-up the initiative to distribute ration kits consisting of rice, dal, spices, tea powder, hygiene products and other essentials to 500 needy families belonging to these villages.

The drive was held in presence of Zilla Panchayat member Dhanalakshmi Gatty and other Gram Panchayat members.

"We were able to provide food to 600 and more families in different villages and to the stranded migrant workers in the city during this time of crisis because of the generous contributions of our staff, alumni and well wishes" says Sr Dr. M. Jeswina A.C.

The College management expresses its gratitude to all donors, especially the staff, alumni and those associated with the college.