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Thiruvananthapuram, Apr 10: Eight foreign nationals from Italy and United Kingdom, who were undergoing treatment in Kerala, have recovered fully from COVID-19, Chief Minister Pinarayi Vijayan said on Thursday.

The state reported 12 more positive cases of coronavirus on Thursday taking the total number of confirmed cases to 357, Vijayan said as he cautioned that the strict vigil against the pandemic will continue.

While the northern districts of Kannur and Kasaragod reported four cases each, two cases were reported from Malappuram district and one each from Kollam and Thiruvananthapuram districts, Vijayan told reporters after a COVID-19 review meeting here.

Of the eight foreign nationals, seven were undergoing treatment at the Ernakulam Medical College Hospital and one in Thiruvananthapuram Medical College Hospital, Vijayan said, adding that some of the patients were in a serious condition.

The seven foreigners from UK, admitted in Ernakulam medical college, were part of the group which had on March 15 tried to leave the country without permission while being under observation at Munnar, a hill station in the state.

The Italian tourist in Thiruvananthapuram was staying at a resort at Varkala near here and was admitted to hospital on March 13, Vijayan said.

"The recovery of this UK tourist group, which comprised of 83 and 76-year-olds is a testimony to our robust healthcare system and good treatment extended to these patients," the chief minister said.

It has been 100 days since the first COVID-19 case was reported in the state and since then, a total of 357 cases have been confirmed and currently, 258 patients are under treatment in different hospitals.

Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.