Cops raid slaughterhouse; arrest 3; seize 3 cows, 200kg meat, 3 vehicles

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, Jun 24: The Karnataka government on Tuesday announced that fever clinics would be established at all district-level and taluk-level hospitals, wherein fever cases would be screened in a separate area.

"Fever clinics to be established at all district hospitals/district-level hospitals and taluk-level hospitals, wherein all fever cases should be screened 24x7 in a separate area and for Influenza-Like Illness (ILI) and Severe Acute Respiratory Illness (SARI) cases to be subjected for swab testing," read a circular from the Department of Health and Family Welfare dated June 22.

The circular said that private institutions in the corporation areas should also be designated as fever clinics.

"100 per cent of Community Health Centres (CHC), 50 per cent of Primary Health Centres and Urban Primary Health Centres (UPHC) to be converted as exclusive fever clinics to screen ILI/SARI during working hours. The remaining PHC/UPHC to cater to non-COVID-19 cases. All health institutions need to have a separate entry for COVID and non-COVID services," the circular further said.

Karnataka on Tuesday reported 322 fresh COVID-19 positive cases and eight deaths.
According to the state health department, the total number of positive cases has mounted to 9,721 and 150 deaths. So far, 6,004 people have been discharged.

Mangaluru, May 6: The Karnataka NRI Forum - UAE has collected the details of those seeking to return to Karnataka amidst coronavirus lockdown.

Of these, 121 of these expats are pregnant women, 27 are senior citizens, 157 are in urgent medical need, 522 are unemployed, 377 are in the UAE on visit visa, 109 are in the UAE on expired residency visa, 30 are students and 566 others.

On Tuesday, May 5, the Government of India released a list of flight schedules for the repatriation of Indians who are stranded abroad. "...sadly we do not see any flights going from UAE to Karnataka," the KNRI said in a letter to Union Minister of Chemicals and Fertilizers D V Sadananda Gowda, who is also a Kannadiga.

"We, Dubai Anivasi Kannadigaru and KNRI have collected the information of those who are in dire condition and would like to travel immediately. We would like to bring to your attention that in this list there are pregnant women and senior citizens who are in critical conditions and are waiting to travel," the KNRI wrote, urging the Union Minister to start at least one flight to Mangaluru as the majority are from this coastal city and not from Bengaluru.

Additionally, in order to help these struggling Kannadigas, the KNRI has notified the Government of India and Government of Karnataka several times through letters and conference calls, along with the Kannadiga's helpline, UAE.

With the help of likeminded businessmen and professionals, the KNRI Forum and Dubai Anivasi Kannadigaru have opened a helpline called "Kannadigas Helpline" through which they have received around 2,500 requests for food, medical, legal and other assistance.