Demonetisation: Banks to use indelible ink while exchanging notes

Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Mangaluru, May 7: Thousands of migrant workers from Uttar Pradesh and Bihar, led by Congress leader Mithun Rai, staged a protest here on Wednesday demanding that they be allowed to return to their native places.

The workers started a protest demonstration opposite Mangaluru City Corporation office in the city. Police dispersed the crowd for violating social distancing norms.

The workers said they have nowhere to go and nothing to eat. Therefore, they are demanding to be sent back to their states. They however, had crowded together without following the social distance norm. 

In the wake of protest, prohibitory orders under section 144(3) were imposed in Dakshina Kannada district between 7pm and 7 am till May 17 to check the spread of Covid-19.

Bengaluru, Apr 11: The coronavirus-driven lockdown will continue for another 15 days, but relaxations will be allowed in a graded manner, Karnataka Chief Minister B S Yediyurappa said after a four-hour-long video conference with Prime Minister Narendra Modi on Saturday.

“Agriculture and industrial sectors will be given relaxation. Government offices will be allowed to work with partial strength. But the PM said detailed guidelines will be issued in two days,” Yediyurappa said, briefing reporters. 

“Importantly, the lockdown for the next two weeks will be different than how it was in the past three weeks. The Centre, keeping in mind economic activities, especially agriculture, industry and employment of labourers, the Centre will tell us what needs to be done,” the CM said.
 
According to Yediyurappa, PM Modi told all chief ministers that the next 2-3 weeks will be critical. “The next few weeks will decide whether or not we have succeeded. If the situation worsens, we have to face the crisis,” Yediyurappa said, quoting Modi. 

Apparently, Modi sought details on the COVID-19 situation from 12-13 states where the situation is grave. “He did not take a report from Karnataka,” Yediyurappa said. “This morning, seven new cases were reported in the state, taking our tally to 214. Nationally, we were in the third place; we’re now 11th,” he said, hailing the efforts of officials involved in fighting the pandemic. 

The CM said it was “inevitable” to continue the lockdown for another 15 days. “But for citizens to get essential supplies, there’s no bar on them going by walk alone. Also, we will see to it that agricultural activities are not affected anywhere,” Yediyurappa said.