Dubai: Mangaluru girl Beulah Ruth Pinto bags 2nd place in ‘BurJuman’s Rising Stars’

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Bengaluru, Feb 26: Congress leaders on Wednesday staged a protest in front of Mahatma Gandhi's statue at Vidhana Soudha here against BJP MLA Basanagouda Patil Yathnal's alleged remarks accusing freedom fighter HS Doreswamy of being a "Pakistani agent".

Former Chief Minister and senior Congress leader Siddaramaiah, KPCC working president Eashwar Khandre also joined the protest.

Yathnal on Tuesday called Doreswamy a fake freedom fighter and a Pakistani agent, while addressing the media.

His comments triggered a controversy drawing sharp remarks from Congress and other parties.

Congress has demanded an apology from Yathnal and has also urged that his Assembly membership be cancelled.

"Session proceedings will not continue until Yathnal apologises," said senior Congress leader HK Patil while addressing the protest earlier today.

Siddaramaiah asserted that making "provocative" comments against such a freedom fighter is obnoxious.

Former KPCC president Dr G Parameshwar said: "Yathnal is a criminal who had mentioned in his election affidavit that he had 27 cases against him. He has made such loose comments against the freedom fighter. He should apologise for his remarks."

Dubai, May 18: An Indian working in a mining company in the UAE has become the latest expatriate to have lost his job for hate-filled social media posts targeting Islam and Muslims.

Brajkishore Gupta was fired without notice for calling Indian Muslims 'coronavirus spreaders' and hailing the Delhi violence as 'divine justice' in his Facebook posts.

Gupta, who is from Chapra, Bihar, was employed by Stevin Rock, a mining company headquartered in Ras Al Khaimah city.

"This isolated incident involving a junior employee was investigated and dealt with immediately resulting in the termination without notice of this person's employment with Stevin Rock," said the company's business development and exploration manager Jean-Francois Milian.

"Our company policy supports the direction of the UAE government in promoting tolerance and equality and strongly renouncing racism and discrimination and we have sent communications to all of our employees irrespective of their religious or ethnic background reminding them that any such behaviour is unacceptable and will lead to immediate dismissal," Milian was quoted as saying in the report.

Three Indians based in the UAE were either fired or suspended from their jobs for "Islamophobic" posts on social media early this month.

On April 20, India's ambassador to the UAE Pavan Kapoor had warned Indian expatriates against such behaviour.

"India and UAE share the value of non-discrimination on any grounds. Discrimination is against our moral fabric and the Rule of law. Indian nationals in the UAE should always remember this," he said in a tweet.

Last month, Sharjah-based businessman Sohan Roy had to apologise for "unintentionally hurting religious sentiments" through his poem, which alluded to a Muslim religious group.

In March, chef Trilok Singh was fired from a restaurant in Dubai for an online threat against a student in Delhi over her views on the Citizenship Amendment Act.