Emmanuel Macron is France's youngest leader since Napoleon

May 8, 2017

Paris, May 8: Three years ago, hardly anyone knew his name.

But in a once-unimaginable scenario, Emmanuel Macron - at 39, the boy wonder of an aging political establishment - won the French presidency Sunday with a tidal wave of popular support. He will soon be France's youngest head of state since Napoleon Bonaparte as well as its first modern president not to belong to either of the center-left or center-right parties that have run this country for 60 years.

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After the success of the Brexit campaign in Britain and the upset victory of Donald Trump in the U.S. presidential election, Macron's win has been billed as having curbed the global tide of anti-establishment populism. In the vote's second and final round, he defeated Marine Le Pen, the leader of the far-right National Front, a strongly anti-immigrant party tainted by the perception that it is tolerant of anti-Semitism and Nazi nostalgia.

"I will fight with all my strength against the division that is undermining and defeating us," Macron said, just after the results were announced. "For the next five years, I will serve on your behalf with humility, devotion and determination."

Macron's story is one of a highly improbable ascent in a system that typically rewards entrenched political dynasties.

"It's entirely unprecedented in the Fifth Republic," said Francois Heisbourg, a well-known French defense expert who has advised Macron on security and terrorism issues. "It's extraordinarily unusual, the way he has broken through the system - coming from nowhere."

Macron, who has never held elected office, has now been elected to one of the most powerful executive offices in the Western world, holding the top job of the second-largest economy in a troubled Europe. How he did it, analysts say, rests on a combination of luck and a campaign message attuned to a new political moment.

In France, 2017 proved an ideal year to run as an independent candidate. A rare political vacuum emerged, and Macron - a former Socialist economy minister who stepped down from his post in July - was able to take full advantage of it.

With the public frightened by a slew of terrorist attacks by Islamist extremists, and with employment at double digits, France's Socialist Party, under incumbent President Francois Hollande, sank to historic levels of unpopularity. Largely for the sake of the party, Hollande promised in December not to seek re-election, but his Socialist stand-in, Benoit Hamon, was eliminated in the election's first round, winning just a meager 6.35 percent of the vote.

France's mainstream conservative party, Les Republicains (the Republicans), were undermined by a spending scandal involving Francois Fillon, its contender. Once the undisputed favorite, Fillon suffered a fatal blow after Le Canard Enchaine, a French satirical newspaper, accused him of funneling about 900,000 euros ($990,000) of public funds to his wife and children for work they never did.

Macron perceived that the "new divide" among French voters was not the historic cleavage between left and right but rather one between an open and closed society, Heisbourg said. This was the line Le Pen and the National Front had embraced for years, but few in the established parties ever responded directly.

Defending an open, multicultural society was a central component of En Marche (Onward), the movement Macron launched in 2016. "Globalization can be a great opportunity," he said at one point on the campaign trail. "There is no such thing as French culture," he said at another. "There is culture in France, and it is diverse."

The great French novels are often stories of ambitious young men from the provinces who come to Paris to seek their fortunes. For many, Macron is no exception. The literary son of doctors from provincial Amiens, he graduated from France's elite Ecole Normale d'Administration, the traditional breeding ground of presidents.

Some in the French press have placed the first sign of Macron's formidable ambitions in, of all places, his love life - namely, in his dogged pursuit of his wife, Brigitte, his former high school teacher and a woman 24 years his senior. As Brigitte Macron told a French documentary maker last year: "Bit by bit, he defeated all my resistance, in an amazing way, with patience." The candidate showed the same persistence in capturing the Elysee Palace.

"I have known failures, sometimes bitter, but I have never allowed myself to turn away," Macron wrote in his 2016 book, "Revolution."

That doggedness - along with a calculating eye for useful associations, critics say - brought him into contact with many prominent French thinkers and government officials, who then helped him advance.

In the late 1990s, while still a graduate student, Macron worked as an assistant to Paul Ricoeur, a prominent French intellectual and writer; by the mid-2000s, he was working for the Finance Ministry, on a commission dedicated to stimulating economic growth. It was there that he met Jacques Attali, a prominent economist and Parisian power broker who many say later ushered Macron along a speedy path to the highest echelons of the Hollande administration.

In an interview, Attali, who has also served as an adviser to the Macron campaign, rejected out of hand the idea that the candidate was mainly a gifted networker. "He would be where he is today with or without my help," Attali said.

If Macron's ambition has led him to considerable success, it has also earned him enemies - including, some say, Hollande, whom he served as economy minister but then abandoned to launch his party. "Emmanuel Macron betrayed me methodically," Hollande said last year, according to Le Monde newspaper.

Jean Pisani-Ferry, another Macron adviser and the author of much of the candidate's platform, brushed off the comment.

"He launched another politics, created a new movement. Political life wouldn't exist otherwise," Pisani-Ferry said in an interview.

Despite the improbable nature of Macron's victory, France's new president will face a considerable challenge as he attempts to form a government. Given that he has no party structure behind him, he will be deeply affected by the results of parliamentary elections, slated for June.

"There is huge uncertainty regarding the parliamentary elections to come, because France's main political forces were largely absent in the second round - the traditional right wing, the Socialists and the far left," said Patrick Weil, a leading French legal scholar and historian. "Now they are frustrated, and they are ready to take their revenge in the legislative elections."

In the past, when the National Front made it to the final round of the presidential election, the rest of the political spectrum united in opposition to the extreme right. But this year, certain politicians hesitated to back Macron in the final round, notably the far-leftist Jean-Luc Melenchon. Many voters also opted to abstain or to cast blank ballots.

"You might have higher mobilization for the parliamentary elections than usual, which, given turnout in the presidential election, could mean a higher legitimacy for the parliament than for the presidency," Weil said.

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Agencies
April 28,2020

Washington, Apr 28: US President while addressing a news conference on coronavirus pandemic said his administration has launched "very serious investigations" into China's response to the novel coronavirus.

"And we are not happy with China, we are not happy with that whole situation, because we believe it could have been stopped at the source," he said. "It could have been stopped quickly and it wouldn't have spread all over the world," the BBC reported.

Trump has been critical of China as the pandemic has progressed and has frequently touted his decision to close the US borders to China in an effort to curb the outbreak. Some health experts have said the effort bought time for the US to prepare, but the Trump administration has been accused of squandering the opportunity.

"Nobody except one country can be held accountable for what happened," Trump said.

"Nobody's blaming anybody here, we're looking at a group of people that should've stopped it at the source."

The US will never forget those who were "sacrificed for a reason of incompetence or something else other than incompetence," he added.

"They" - referring to China - "could've protected the whole world - not just us - the whole world," he said.

At the starting of the conference Trump said COVID-19 cases are declining or stablising across the country.

"In all cases getting better," he said. "Really a horrible situation that we've been confronted with, but they're moving along."

He added there's a "hunger" to get back to work.

"Ensuring the health of our economy is vital to ensuring the health of our nation - these goals work in tandem."

The president has suggested an unnamed individual "a long time ago" could have stopped the "unnecessary death[s]" due to COVID-19.

"There has been so much unnecessary death in this country," he said.

"It could've been stopped and it could've been stopped short, but somebody a long time ago, it seems, decided not to do it that way and the whole world is suffering because of it."

He did not say who he was referencing and gave no other details.

Trump was asked if he has considered delaying the November presidential election.

"I never even thought of changing the date of the election," he answered. "Why would I do that? November 3rd. That's a good number."

Trump called the suggestion "made up propaganda" and said that "sleepy Joe" Biden - his presumptive Democratic rival - was likely unaware his campaign had put the statement out.

Former Vice-President Joe Biden said at a virtual fundraiser last week that he thought Trump would "try to kick back the election somehow".

The president has frequently levelled insults at his Democratic opponent by questioning the former vice-president's mental fortitude.

"I look forward to that election," Trump said.

The president responded to a question criticising Health Secretary Alex Azar's early downplaying of the disease by saying it was "unfair". He claimed Democrats did the same, including Speaker of the House of Representatives Nancy Pelosi.

"I was very fortunate through luck or whatever that we closed the border, we put a ban on China," he said.

"But I could tell you that Nancy Pelosi was dancing in the streets in Chinatown. She wanted to go, let's go out and party. That was late in February."

Back in February, Pelosi had encouraged people to visit San Francisco's Chinatown to help struggling businesses. She did not propose any parties, as the president suggested.

The city issued a stay-at-home order in March.

A reporter asked: If an American president loses more Americans over the course of six weeks than died during the entirety of the Vietnam war, does he deserve to be reelected?

Trump took the question in stride.

"So, yeah, we've lost a lot of people but if you look at what original projections were, 2.2 million, we're probably heading to 60,000 - 70,000," he said.

"It's far too many - one person is too many for this. I think we've made a lot of really good decisions," he added. "The big decision was closing the border, doing the ban on people coming in from China."

He also brings up the "unbelievable" job his administration did with ventilators.

"I think we've done a great job. And I will say this - one person is too many."

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News Network
April 28,2020

Washington, Apr 28: After nearly three weeks in an intensive care unit in Los Angeles, doctors treating 41-year-old Broadway actor Nick Cordero for COVID-19 were forced to amputate his right leg.

The flow of blood had been impeded by a blood clot: yet another dangerous complication of the disease that has been bubbling up in frontline reports from China, Europe and the United States.

To be sure, so-called "thrombotic events" occur for a variety of reasons among intensive care patients, but the rates among COVID-19 patients are far higher than would be otherwise expected.

"I have had 40-year-olds in my ICU who have clots in their fingers that look like they'll lose the finger, but there's no other reason to lose the finger than the virus," Shari Brosnahan, a critical care doctor at NYU Langone said.

One of these patients is suffering from a lack of blood flow to both feet and both hands, and she predicts an amputation may be necessary, or the blood vessels may get so damaged that an extremity could drop off by itself.

Blood clots aren't just dangerous for our limbs, but can make their way to the lungs, heart or brain, where they may cause lethal pulmonary embolisms, heart attacks, and strokes.

A recent paper from the Netherlands in the journal Thrombosis Research found that 31 percent of 184 patients suffered thrombotic complications, a figure that the researchers called "remarkably high" -- even if extreme consequences like amputation are rare.

Behnood Bikdeli, a doctor at New York-Presbyterian Hospital, assembled an international consortium of experts to study the issue. Their findings were published in the Journal of The American College of Cardiology.

The experts found the risks were so great that COVID-19 patients "may need to receive blood thinners, preventively, prophylactically," even before imaging tests are ordered, said Bikdeli.

What exactly is causing it? The reasons aren't fully understood, but he offered several possible explanations.

People with severe forms of COVID-19 often have underlying medical conditions like heart or lung disease -- which are themselves linked to higher rates of clotting.

Next, being in intensive care makes a person likelier to develop a clot because they are staying still for so long. That's why for example people are encouraged to stretch and move around on long haul flights.

It's also now clear the COVID-19 illness is associated with an abnormal immune reaction called "cytokine storm" -- and some research has indicated this too is linked to higher rates of clotting.

There could also be something about the virus itself that is causing coagulation, which has some precedent in other viral illnesses.

A paper in the journal The Lancet last week showed that the virus can infect the inner cell layer of organs and of blood vessels, called the endothelium. This, in theory, could interfere with the clotting process.

According to Brosnahan, while thinners like Heparin are effective in some patients, they don't work for all patients because the clots are at times too small.

"There are too many microclots," she said. "We're not sure exactly where they are."

Autopsies have in fact shown some people's lungs filled with hundreds of microclots.

The arrival of a new mystery however helps solve a slightly older one.

Cecilia Mirant-Borde, an intensive care doctor at a military veterans hospital in Manhattan, told AFP that lungs filled with microclots helped explain why ventilators work poorly for patients with low blood oxygen.

Earlier in the pandemic doctors were treating these patients according to protocols developed for acute respiratory distress syndrome, sometimes known as "wet lung."

But in some cases, "it's not because the lungs are occupied with water" -- rather, it's that the microclotting is blocking circulation and blood is leaving the lungs with less oxygen than it should.

It has just been a little under five months since the virus emerged in Wuhan, China, and researchers are learning more about its impact every day.

"While we react surprised, we shouldn't be as surprised as we were. Viruses tend to do weird things," said Brosnahan.

While the dizzying array of complications may seem daunting, "it's possible there'll be one or a couple of unifying mechanisms that describe how this damage happens," she said.

"It's possible it's all the same thing, and that there'll be the same solution."

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News Network
April 10,2020

Melbourne, Apr 10: Scientists have identified six drug candidates from more than 10,000 compounds that may help treat COVID-19.

The research, published in the journal Nature, tested the efficacy of approved drugs, drug candidates in clinical trials and other compounds.

"Currently there are no targeted therapeutics or effective treatment options for COVID-19," said Professor Luke Guddat from the University of Queensland in Australia.

"In order to rapidly discover lead compounds for clinical use, we initiated a programme of high-throughput drug screening, both in laboratories and also using the latest computer software to predict how different drugs bind to the virus," Guddat said.

The project targeted the main COVID-19 virus enzyme, known as the main protease or Mpro, which plays a pivotal role in mediating viral replication, the researchers said.

This makes it an attractive drug target for this virus, and as people don't naturally have this enzyme, compounds that target it are likely to have low toxicity, they said.

"We add the drugs directly to the enzyme or to cell cultures growing the virus and assess how much of each compound is required to stop the enzyme from working or to kill the virus. If the amount is small, then we have a promising compound for further studies," said Guddat.

After assaying thousands of drugs, researchers found of the six that appear to be effective in inhibiting the enzyme, one is of particular interest.

"We're particularly looking at several leads that have been subjected to clinical trials including for the prevention and treatment of various disorders such as cardiovascular diseases, arthritis, stroke, atherosclerosis and cancer," Guddat said.

Researchers said compounds that are already along the pipeline to drug discovery are preferred, as they can be further tested as antivirals at an accelerated rate compared to new drug leads that would have to go through this process from scratch.

"With continued and up-scaled efforts we are optimistic that new candidates can enter the COVID-19 drug discovery pipeline in the near future," Guddat said.

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