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May 12: Children suffering from non-respiratory disease symptoms like diarrhea and fever, or those with a history of exposure to the novel coronavirus, should be suspected of having COVID-19, a new study says.

According to the research, published in the journal Frontiers in Pediatrics, gastrointestinal symptoms first suffered by some children hints at potential infection with SARS-CoV-2 through the digestive tract.

"This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children," the scientists from Tongji Hospital in China wrote in the study.

They explained that the gastrointestinal symptoms could be arising since the type of receptors in lung cells targeted by the virus can also be found in the intestines.

Most children are only mildly affected by COVID-19, and the few severe cases often have underlying health issues, the researchers said.

"It is easy to miss its diagnosis in the early stage, when a child has non-respiratory symptoms, or suffers from another illness," said study co-author Wenbin Li, who works at the Department of Pediatrics, Tongji Hospital.

"Based on our experience of dealing with COVID-19, in regions where this virus is epidemic, children suffering from digestive tract symptoms, especially with fever and/or a history of exposure to this disease, should be suspected of being infected with this virus," Li said.

In the study, the scientists described the clinical features of children admitted to hospital with non-respiratory symptoms, who were subsequently diagnosed with pneumonia and COVID-19.

"These children were seeking medical advice in the emergency department for unrelated problems, for example, one had a kidney stone, another a head trauma," Li said.

The study noted that all the children had pneumonia, which was confirmed by chest X-ray scan before or soon after admission.

These children were then confirmed to have COVID-19.

While their COVID-19 symptoms were initially mild or relatively hidden before their hospital admission, four out of the five cases had digestive tract symptoms as the first manifestation of this disease, the researchers said.

Li hopes that doctors will use the findings to quickly diagnose and isolate patients with similar symptoms, which may aid early treatment and reduce transmission.

According to the researchers, the children's gastrointestinal symptoms, which have also been recorded in adult patients, could be an additional route of infection.

"The gastrointestinal symptoms experienced by these children may be related to the distribution of receptors and the transmission pathway associated with COVID-19 infection in humans," Li explained.

Since the virus infects people via the ACE2 receptor, which can be found in certain cells in the lungs as well as the intestines, COVID-19 might infect patients not only through the respiratory tract in the form of air droplets, but also through the digestive tract by contact or fecal-oral transmission, the study noted.

While COVID-19 tests can occasionally produce false positive readings, Li said all the five children assessed in the study were infected with the disease.

However, he cautioned that more research is needed to confirm their findings.

"We report five cases of COVID-19 in children showing non-respiratory symptoms as the first manifestation after admission to hospital. The incidence and clinical features of similar cases needs further study in more patients," he said.

Bengaluru, Feb 6: Chief Minister B S Yediyurappa inducted 10 BJP MLAs to his Cabinet here on Thursday. They are among the 17 Congress-JD(S) MLAs who defected last year.

The much-delayed expansion came almost two-months after the MLAs won the bypolls held in December. During the period, the defectors camp exerted pressure on Yediyurappa to expand the Cabinet and include all the MLAs who contested the bypolls.

The new ministers sworn in are S T Somashekar, Ramesh Jarkiholi, Byrati Basavaraj, K Gopalaiah, B C Patil, Dr K Sudhakar, Shivaram Hebbar, Anand Singh, Narayana Gowda and Shrimanth Patil.

One of the 11 MLAs from the defectors camp, Mahesh Kumathalli was not inducted as he hailed from the same constituency as Deputy Chief Minister Laxman Savadi. Three others, MTB Nagaraj, H Vishwanath and R Shankar are likely to be inducted in June.

Governor Vajubhai Bala administered oaths to the new ministers at Raj Bhavan, where hundreds of supporters came to witness the event. Authorities had also beefed up security arrangements outside Raj Bhavan for the ceremony.

Earlier, Yediyurappa was to induct 10 newly-elected MLAs and three old-timer BJP MLAs. But on Wednesday evening, the BJP's central leadership stepped in to decide that only 10 newly-elected MLAs should be inducted after disgruntlement surfaced among BJP MLAs over former minister C P Yogeeshwar's induction.

Several MLAs led by chief minister's political secretary MP Renukacharya had raised a hue and cry over allotting berths to those who lost Assembly polls. A group of 13 to 15 MLAs had also demanded adequate representation to Kalyana Karnataka region, alleging that the new Cabinet had excess representation from few districts of Karnataka, such as Bengaluru Urban and Belagavi.

Bengaluru, Apr 15: With the reporting of the death of an 80-yr-old female from Hirebagewadi taluk in Belagavi district, the number of persons, who were died due to COVID-19 related disease, increased to 12, in Karnataka on Wednesday.

According to official sources, the deceased was a relative of another COVID-19 infected person, was succumbed to death this morning at a designated Hospital in Belagavi district.