Free bus, Metro passes to elders if JD(S) comes to power: HDK

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Karanataka, Apr 20: Chief Minister of Karnataka BS Yediyurappa launched an online crash course programme 'GetCETGo', here on Monday.

GetCETGo is the state government's free online crash course programme to help all students of Karnataka prepare for Common Entrance Test (CET) and National Eligibility-cum-Entrance Test (NEET).

The programme was launched by the state government amid the disruption in education sector caused due to the nationwide COVID-19 lockdown.

Students can access the content through the web portal and the Android Application that has been developed by Sinchu Infotech and Deeksha Online.

They can also avail comprehensive study material with practice questions, chapter-wise tests, revision videos and mock tests.

According to the state government, this programme will benefit around 1,94,000 students.

Bengaluru, May 23: Karnataka reported 216 covid-19 positive cases in last 24 hours, marking the highest single day spike in the state ever since the first case was detected on 8 March. 187 of these 216 patients have recently returned from Maharashtra.

A 32-year old male resident of Bengaluru died on Saturday making it the 42nd fatality in the state.

The spike on Saturday takes the total number of covid-19 positive closer to the 2,000 mark and the number of active cases to 1,307 in the state, according to the daily health bulletin of the health department.

Yadgir in northern Karnataka recorded 72 cases on Saturday while Raichur recorded 40 cases. Cases in the sugarcane growing region of Mandya continued to rise as 28 people tested positive on Saturday that takes the total number of active cases to 211 as against Bengaluru that has 124.

Gadag registered 15 cases while Bengaluru recorded 4 cases.

Most of those who tested positive on Saturday had returned from other states, especially Maharashtra, one of the worst affected regions in the country.

The spike in cases comes even as the B.S.Yediyurappa-led state government is deliberating further easing of lockdown restrictions post 31 May. The state government has already resumed public bus and train services as well to facilitate inter-district movement of people that has added to fears of spreading the virus from cities to villages where healthcare infrastructure is poor and inadequate.

Karnataka will also see domestic flight arrivals from Monday.

In a statement on Saturday, Bengaluru International Airport said that it introduced ‘Parking-to-Boarding contactless’ journey.

“We have introduced innovative contactless procedures to minimise exposure at the Airport. These enhancements demonstrate our continued commitment to keep our passengers safe in this environment," said Hari Marar, managing director and chief executive of the airport said in a statement on Saturday.