Govt to bear Rs 78 cr cost of 108-ft-tall Kempegowda statue outside Airport: DyCM

Kundapur, Apr 28: The local police have arrested two people for threatening and preventing an Associated Social Health Activist (ASHA) workers from discharging their duties during the lockdown.

Police said on Tuesday that the arrested are Sandeep Mesta and Mahesh Kharvi.

According to official sources, the health officials had put Sandeep under quarantine for 28 days.

However, he was seen wandering in the streets and ASHA worker C Laxmi warned him to stay indoors.

Irked by the warning Sandeep, along with his friend Mahesh Kharvi waylaid her and threatened to kill for objecting his movement.

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Mangaluru/Bengaluru, Jan 23: A day after two senior functionaries of the BJP — a deputy chief minister and a political secretary to the chief minister — made provocative speeches against a minority community, Nalin Kumar Kateel, state president of the saffron party, on Wednesday issued a gag order, banning functionaries from talking on issues without the party’s approval.

Deputy CM Govind Karjol and Honnalli legislator MP Renukacharya had passed comments castigating Muslims, in the process seriously denting the image of the party which is trying to avoid controversies in its efforts to allay fears on the Citizenship (Amendment) Act. The comments come on the heels of Ballari City legislator Somashekara Reddy warning Muslims at a pro-CAA rally of repercussions if they do not fall in line.

Kateel said a gag order has been “clearly” communicated to all concerned at a recent meeting that he and chief minister BS Yediyurappa had chaired. “Our message to party functionaries is in line with what Prime Minister Narendra Modi has told his council of ministers and party MPs — to focus on their work and constituencies rather than comment on issues. Let them leave this task to official spokespersons of the party,” Kateel said.

However, it appears the message hasn’t gone through to Renukacharya, Yediyurappa’s political secretary. A day after courting controversy by saying anti-nationals were using mosques to store weapons, Renukacharya said he stood by his comments and launched a fresh tirade against madrasas, saying they were manipulating youth and encouraging terrorism.

Speaking to reporters on Wednesday, Renukacharya said: “In our [temple-run] institutions, nothing anti-national is taught. We only teach values that are mandated for life. But at madrasas, youth are manipulated by teaching terrorism. Why do we need such schools? The majority of those accused of terrorism are Muslims.”

He immediately followed up this comment by saying he did not imply all Muslims were terrorists. The Honnalli MLA justified his comments saying he did not receive a single Muslim vote in the 2018 assembly elections. “They [Muslims] come to us seeking our help. They want the BJP for development, but when it comes to elections, they vote for Congress and JD(S),” Renukacharya said. He said no “special packages” will be distributed to Muslims in his constituency.