Herbal remedies may help kids with gastrointestinal issues

May 6, 2017

May 6: Many parents of children with debilitating gastrointestinal disorders may be frustrated by the lack of good treatment options and tempted to try herbal remedies at home, but a new study suggests they should proceed with caution.

medicineResearchers examined data from 14 previously published studies with a total of 1,927 children suffering from problems like diarrhea, dehydration, colic, constipation, abdominal pain and irritable bowel syndrome. They didn’t have enough data to combine results from multiple small studies to offer definitive proof that herbal remedies might work for any of these health problems.

But some of the small studies did suggest certain herbal medicines might help ease diarrhea, abdominal pain and colic. And the studies didn’t find serious side effects associated with herbal remedies.“The lack of conclusive research is unfortunately a general problem in pediatrics, but a special problem in herbal medicine is that for many herbal remedies no licensed and standardized products are available,” said lead study author Dr. Dennis Anheyer of the University of Duisburg-Essen in Germany.

In other words, even if evidence shows an herb may be safe and effective for a specific health problem, that doesn’t necessarily mean that every single version of that herb available for sale would work as well or be free of side effects.

When researchers looked at four studies with a total of 424 participants, they found some evidence suggesting that a variety of herbal remedies might help diarrhea: a plant in the rose family called potentilla erecta, carob bean juice, and an herbal compound preparation with chamomile.

One study with 120 participants also suggests that peppermint oil might help curb the duration, frequency and severity chronic abdominal pain that doesn’t have a clear medical explanation.And, fennel might help ease colic symptoms in babies according to a review of five small studies of herbal remedies for infant colic.

While it’s possible herbal remedies might be used in addition to traditional medications or to help reduce reliance on drug therapy, parents should still see a doctor before trying out herbal therapies on their own, Anheyer said by email.

Another reason for caution is that even the studies in the current analysis that found herbal remedies effective don’t show how large the effects are, noted Dr. Peter Lucassen, a researcher at Radboud University Medical Center in the Netherlands who wasn’t involved in the study.

These small studies might get results that find herbs are statistically better than no treatment or alternative therapies, but the difference still might not be big enough to have a meaningful clinical impact on patients’ symptoms, Lucassen said by email.“I would not advocate any of the herbal medicine because the article does not provide any data about how large the effects are,” Lucassen said.

Often, herbal remedies combine a variety of ingredients and use differing amounts of the main ingredients, which may alter how well they work and how safe they are for kids, Lucassen added. They might also contain chemicals not found in prescription medications that have dangerous side effects or a risk of overdose.

And there’s another reason parents shouldn’t try herbal remedies without seeing a doctor.“Delayed diagnosis might be the result of herbal medications because parents seek help too late because they try the herbs first,” Lucassen said.

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Agencies
January 12,2020

Washington D.C., Jan 12: Disruption in one night's sleep can lead to getting Alzheimer's disease, a recent study has stated.

The interruption in the sound sleep for a single night aggravates the level of tau protein in any young male's body, thus gives rise to the chances of developing the disease.

According to CNN, the report was published on Wednesday in neurology, the medical journal of the American Academy of Neurology.

"Our study focuses on the fact that even in young, healthy individuals, missing one night of sleep increases the level of tau in blood suggesting that over time, such sleep deprivation could possibly have detrimental effects," says study author Dr Jonathan Cedernaes, a neurologist at Uppsala University in Sweden.

As defined by the Alzheimer's Association, tau is the name of a protein that helps in stabilizing the internal structure of the brain's nerve cells. An abnormal build-up of tau protein in the body can end up in causing interior cells to fall apart and eventually developing Alzheimer's.

"When you get more of that deep sleep and you get the REM sleep in the normal amounts, that improves clearance of abnormal proteins which we think is good," said Mayo Clinic neurologist Dr Donn Dexter, not the study author but a fellow of the American Academy of Neurology.

Earlier studies have also shown that getting deprived of sleep can allow higher tau development and accumulation. Thus that poor sleep can hasten the development of cognitive issues.

Researchers caution that the study is small and inconclusive, and acknowledged they were not able to determine what the increased levels might mean.

"This study raises more questions than answers," agreed Dexter on a concluding note, sharing, "What this is telling us is that we have to dig more deeply. Despite something we do for a third of our lives, we know so little about sleep and we're learning every day, particularly when it comes to sleep and dementia."

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Agencies
March 27,2020

New Delhi, Mar 27: The Centre has restricted sale and distribution of "hydroxychloroquine" declaring it as an essential drug to treat the COVID-19 patients and meet the requirements of emergency arising due to the pandemic.

The Ministry of Health and Family Welfare on Thursday made the announcement making it clear that the order "shall come into force on the date of its publication in the official Gazette".

In the order, the government declared that the Central government is "satisfied that the drug hydroxychloroquine is essential to meet the requirements of emergency arising due to pandemic COVID-19 and in the public interest, it is necessary and expedient to regulate and restrict the sale and distribution of the drug 'hydroxychloroquine' and preparation based thereon for preventing their misuse".

"Now, therefore, in exercise of the powers conferred by Section 26B of the Drugs and Cosmetics Act, 1940 (23 of 1940), the Central government hereby directs that sale by retail of any preparation containing the drug Hydroxychloroquine shall be in accordance with the conditions for sale of drugs specified in Schedule H1 to the Drugs and Cosmetics Rules, 1945."

The order came at a time when the novel coronavirus claimed 16 lives and infected over 600 people across India.

The announcement regarding ban of sale and distribution of the drug was made by the government earlier but it issued an official Gazette notification on Thursday signalling that hydroxychloroquine -- an anti-Malaria drug -- will work as a medicine for treating coronavirus infected patients as well.

Recently, the national task force for COVID-19 constituted by Indian Council for Medical Research (ICMR) has recommended hydroxy-chloroquine as a preventive medication.

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Agencies
June 4,2020

The World Health Organisation on Wednesday said that anti-malarial drug hydroxychloroquine (HCQ) will return to the solidarity trial for the potential treatment of coronavirus disease.

At a press conference in the WHO headquarters in Geneva, Director General Tedros Adhanom Ghebreyesus said: "On the basis of the available mortality data, the members of the committee recommended that there are no reasons to modify the trial protocol. The Executive Group received this recommendation and endorsed continuation of all arms of the solidarity trial, including hydroxychloroquine."

The world health body had temporarily suspended the usage of HCQ from the solidarity trial for coronavirus treatment on May 25 soon after a study published in one of the most reliable medical journals, which had suggested that the drug could cause more fatalities among COVID-19 patients.

However, the WHO chief said that the decision was taken as a precaution while the safety data was reviewed.

Ghebreyesus also said that the Data Safety and Monitoring Committee will continue to closely monitor the safety of all therapeutics being tested in the solidarity trial.

"So far, more than 3,500 patients have been recruited in 35 countries. WHO is committed to accelerating the development of effective therapeutics, vaccines and diagnostics as part of our commitment to serving the world with science, solutions and solidarity," he said.

Soon after HCQ was suspended from the trial, the Indian government had said that the antimalarial drug has been known for its benefits for a long time and its usage will be continued on the frontline workers, including police and healthcare professionals, as prophylaxis. The government had also said that studies were being conducted and the drug would be included in the clinical trial also for the treatment of coronavirus disease.

US President Donald Trump also had strongly advocated the use of HCQ and called it a "game-changer". He went to the extent of saying that he had taken the medicine.

Launched by WHO and partners, solidarity trial is an international clinical trial to find an effective treatment for COVID-19, including drugs to slow the progression of the disease or improve survival. The trial, which enrols patients from different countries, "will compare four treatment options against standard of care to assess their relative effectiveness against COVID-19", said WHO. 

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