Here's How IIT Madras Students Are Making Wound Healing Easier For Diabetics

Agencies
May 8, 2018

Students at IIT Madras have developed a novel wound dressing material that would help diabetic patients heal faster. The dressing material uses graphene-based compounds. Wound healing in diabetic is not as rapid as compared to a normal, healthy individual. This delayed healing or non-healed wounds could lead to serious complications and in worse cases call for amputations too. 

In a bid to contribute to the major clinical challenge, students at IIT Madras have come up with a  new wound healing material. The researchers said, that they were aiming to exploit the property of graphene-based materials of improving blood vessel formation at certain concentrations to prepare an inexpensive wound dressing. In the animal studies conducted, the psyllium-reduced graphene oxide nanocomposite showed emphatic results.  

"We hope this is the first step towards developing inexpensive wound dressings using graphene-based materials for clinical use," said Vignesh Muthuvijayan, Assistant Professor, Department of Biotechnology. The researchers used a convex lens to focus sunlight on graphene oxide to obtain reduced graphene oxide. "Thereafter, they loaded these reduced graphene oxide dispersions into a plant carbohydrate polymer (psyllium) solution to obtain wound dressing scaffolds. 

The researchers used fibroblast cells which are responsible for wound healing to evaluate the toxicity and bioactivity of these scaffolds on the cell attachment, migration and proliferation. 

"These newly developed scaffolds provide a suitable tissue-friendly environment for cells and subsequently improve cell proliferation and attachment," Muthuvijayan added.
 
The trials and results revealed that the normal wounds treated with the dressings healed in 16 days as compared to 23 days in untreated normal wounds. Similarly, diabetic wounds treated with the dressings healed in 20 days as against 26 days in untreated diabetic wounds. "These scaffolds are easy to prepare, inexpensive, and show excellent healing properties. Thus, the material acts as a good wound dressing and helps in accelerated healing of normal and diabetic wounds," he said.

Diabetes refers to a group of diseases that result in too much sugar in the blood (high blood glucose). The sugar spike is due to an impaired insulin hormone, that triggers abnormal metabolism of carbohydrate and hike in sugar levels. Your diet and nutrition can play a significant role in managing diabetes. Here are some healthy dietary tips you should make part of your daily regime now.

Follow a balanced diet with complex carbs: According to Preeti Rao, Health and Wellness Coach, eating a variety of fruits and vegetables, lean protein and good sources of fat is very essential for diabetes management. One must avoid trans fats (also called hydrogenated fat), processed food, and sugar and up intake of complex carbs. Complex carbohydrates are rich in fiber and are not highly processed like refined carbohydrates. They take longer to digest and hence provide a sustained source of energy for a longer duration.

Include more Low GI Foods: Glycemic Index (GI) is a relative ranking of carbohydrate in foods according to how they affect blood glucose levels. Carbohydrates with a low GI value (55 or less) are more slowly digested, absorbed and metabolised and cause a lower and slower rise in blood glucose. Low GI foods are also rich in fibre which takes the longest to digest, make you feel fuller for a longer time and help control appetite. This could further help in weight management. Tomato, spinach, guavas, cauliflower, and pears are some low glycemic index foods you can choose to add to your diet.

Avoid Sugary Drinks and Fruit Juices: Diabetics should steer clear of aerated and sugary drinks, various studies and reports have time and again reinforced that these drinks are full of liquid calories and can cause major spike in the blood sugar levels. Your can of fruit juice is not one of the healthiest substitutes either. Fruit juices especially packaged fruit juices are loaded with fructose that elevates the blood sugar levels. It is advisable to eat whole fruits instead. Fruits are full of fibres, fibres take time to metabolise and thus doesn't result in sudden surge in blood sugar levels. Eat fruits that have a low glycemic index. Eat fruits with some nuts and olives to balance the glycemic load.

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Agencies
February 27,2020

Washington D.C, Feb 27: New research shows that adults who have low fruit and vegetable intake are more likely to be diagnosed with an anxiety disorder.

"For those who consumed less than 3 sources of fruits and vegetables daily, there was at least at 24% higher odds of anxiety disorder diagnosis," says the lead author of the Canadian Longitudinal Study, Karen Davison, who is a health science faculty member, nutrition informatics lab director at Kwantlen Polytechnic University, (KPU) and North American Primary Care Research Group Fellow.

"This may also partly explain the findings associated with body composition measures. As levels of total body fat increased beyond 36%, the likelihood of anxiety disorder was increased by more than 70%," states co-author Jose Mora-Almanza, a Mitacs Globalink intern who worked with the study at KPU.

"Increased body fat may be linked to greater inflammation. Emerging research suggests that some anxiety disorders can be linked to inflammation," says Davison.

In addition to diet and body composition measures, the prevalence of anxiety disorders also differed by gender, marital status, income, immigrant status and several health issues.

An important limitation of the study was that the assessment of anxiety disorders was mostly based upon self-reporting of a medical diagnosis.

"It is estimated that 10% of the global population will suffer from anxiety disorders which are a leading cause of disability," says Karen Davison

"Our findings suggest that comprehensive approaches that target health behaviours, including diet, as well as social factors, such as economic status, may help to minimize the burden of anxiety disorders among middle-aged and older adults, including immigrants," she concluded.

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Agencies
February 23,2020

Los Angeles, Feb 23: According to researchers, if administered quickly, a common medication that reduces bleeding could be a treatment for bleeding stroke.

The Spot Sign and Tranexamic Acid on Preventing ICH Growth - Australasia Trial (STOP-AUST) was a multicenter, prospective, randomized, double-blind, placebo-controlled, phase 2 clinical trial using the antifibrinolytic agent tranexamic acid in people with intracerebral hemorrhage (ICH).

ICH is a severe form of acute stroke with few treatment options.

Tranexamic acid is currently used to treat or prevent excessive blood loss from trauma, surgery, tooth removal, nosebleeds and heavy menstruation. For this study, one hundred patients with active brain bleeding were given either intravenous tranexamic acid or placebo within 4.5 hours of symptom onset.

Researchers analyzed brain CT scans taken during the 24-hour period after treatment with tranexamic acid or placebo.

Researchers found a trend towards reduced hemorrhage expansion in the group treated with tranexamic acid, especially in those treated within 3 hours of the brain bleed. However, this trend was not statistically significant. The finding was consistent with previous research using the medication.

"Further trials using tranexamic acid are ongoing and focusing on ultra-early treatment - within 2 hours. 

This is where the greatest opportunity for intervention appears to be. Tranexamic acid is inexpensive, safe and widely available. Our results and others provide great impetus for further, focused research using this treatment," Nawaf Yassi said.

Larger trials focused on patient outcomes are required for this therapy to enter routine clinical practice.

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Agencies
February 24,2020

Singapore, Feb 24: Last week Singapore's Ministry of Trade and Industry revised their 2020 GDP growth projections downwards to -0.5 to 1.5 per cent, confirming fears of economic fallout from the coronavirus COVID-19. Just three days earlier, while visiting Changi Airport, the Prime Minister told the media that the country is bracing for a significant hit on the economy and the possibility of a recession.

In the budget announcement on February 18, various measures to help affected companies were announced.

This included a jobs support scheme to help companies retain workers that will see the government offset 8 per cent of wages up to SGD3,600(USD2,600) per worker, per month, for a three-month period. Companies will also get a 25 per cent rebate on their taxes for the year capped at SGD15,000 (USD10,800) per company.

There will be additional support for sectors directly affected by the virus outbreak such as tourism, aviation and retail. Qualifying companies will be given property tax rebates and can apply for temporary bridging loans to ease cash flow. Rebates will be offered on aircraft landing and parking charges as well as rental rebates for shops and cargo agents at Changi Airport.

Overall, the economic package will cost Singapore some USD 4.6 billion, well in excess of the USD 500 million some analysts had predicted. The resulting spending plan including the virus economic package will see a budget deficit of SGD 10.9 billion or 2.1 per cent of GDP, the highest since the Asian financial crisis of 1997.

It is hoped that with financial support, companies in Singapore will not only be able to ride through the current rough patch but be able to position themselves better to take off once the economic crisis brought upon by the contagion is over.

Which then are the Singapore companies that can potentially ride out the current storm and emerge stronger?

Aviation and hospitality firms are among those most impacted by the virus outbreak and Singapore Airlines (SIA) comes to mind. SIA is a well-run company but has seen its share price fall about 5.2 percent since the beginning of the year. In the short term, revenue and profits will no doubt be affected but it will recover in the long run.

Hospitality sector companies like Ascott Residence whose main sponsor is Capitaland, Southeast Asia's largest landlord, and CDL Hospitality, have seen 1.5 and 5.5 percent (respectively) shaved off their share prices since the start of the year.

In reporting financial results for the quarter which ended in December on February 14, Alibaba CEO Daniel Zhang said that due to the virus, they are seeing large changes in buying patterns. With widespread home confinement, there is a growing demand for delivery services including online food and grocery delivery, as well as office apps and streaming entertainment.

Similarly, in Singapore, with more people staying and working from home, the three main food delivery services, Grab Food, Foodpanda and Deliveroo, are doing roaring business. All three are privately held.

In late January, as the scale of the outbreak became more apparent, investors began pouring money into health-product firms in Asia that they think will benefit from the virus outbreak.

Bloomberg reported that when Chinese pharmaceutical companies like Da An Gene Co, Xilong Scientific and Shanghai Kehua Bio-Engineering said they have developed kits for detecting the virus, their stocks soared to hit the 10 per cent daily limit. Firms manufacturing protection gear and air-cleaning equipment climbed more than 10 per cent in Japan, while Malaysian rubber gloves producers climbed at least 5 per cent.

Naturally, many would view that pharmaceutical companies that have the technology and expertise to develop drugs to treat patients with the virus or are able to develop a vaccine, would stand to benefit from the coronavirus outbreak.

Firms like and Johnson & Johnson, Pfizer, MSD, GlaxoSmithKline (GSK) and Sanofi are the pharmaceutical behemoths that dominate the global vaccine market.

However, industry experts speaking to the BBC warned that a pot of gold is not necessarily waiting for any company that successfully develops a vaccine. Although the global vaccine market is expected to grow to USD60 billion this year, it is costly and time-consuming to develop and pass it through for use by the general public.

It is also unclear if Indian pharmaceutical firms will be able to benefit from the demand for medicines that can treat or prevent the virus.

India is the world's largest manufacturer of generic drugs and it supplies 20 percent of the world's drugs by volume. However, it sources 70 percent of its raw material from China. If supplies are disrupted beyond a month to a month and a half, they may see a slow-down in production. According to a CNN report, the companies that are most impacted by material shortages are GSK India, Pfizer (PFE) and Cipla. Other companies like Aurobindo Pharma, Cadila Healthcare and Sun Pharma are said to be carefully monitoring the situation.

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