Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.
However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.
New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.
The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.
It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.
"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.
As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.
"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.
"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.
To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.
At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.
Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.
In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.
They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.
Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.
The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.
Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.
Comments
Ya ya rightly said bopanna...90% of rapes world wide done by them only ..mustapanna ...piece kabab country kananna adu ...
Third rated person from third rated community ...he must be sent for 5 years jail...in their community women are treated as property ...no voice and no respect for opinion ...jail that rapist ..ley sheikh koorappa saaku ...u don't have any rights to say that. .....frustration yaargappa sameee...jihadists are highly frustrated across the globe ...India dallanthu ..burnol sales day by day jaasthine agtha ide...Russians are banging kaali plate of Islamic state ...Islamic banana republic of porkistan are banged up by RAW ,Chinese are banging third rated in people and asking them to shave their beards ..turkey itself getting banged front and back ...no need to say about Israelis ..haha ..Israel hesru helidre ...loose motion suru Agathe jihadi galige ..haha ..adu bidi maarre ...papa the Jana Myanmar navaru jihadi gala attahaasavannu end madlikke rohingya galanna odistha iddare ..mostly bunder nalli iro bunder galige artha agalla ..yaake Andre avakke tale ne tirgalla ..tale yaake tirgalla Andre mallya juice haakalla ...haha...baa maams siddu has brought down on tax on wine...neenu hodi .sheikh GU haaksu ...burnol ge haako dudnslli swalpa karch maadi aitha ?...haha
.... But still, islum has more rapists and thrives per 100 of population .....
Aslum gussa mat Ho ! Islam is full of peas ! Happy ?
Bopanna,
Just shut your mouth, in each religion, each city, each country there is good and bad people, it doesn't mean what you barking!! Senseless fellow...
At what age did wish a get married ?
BhaiLog, sach kadva hots hai.
Why u lot barking when u hear the truth ? Look at most rapes who is behind it ? In Kerala one girl killed by whom ? ANWAR UL ISLAM !!!
Bopanna is your name is named by your parents? or r u shamed of your name which your parents named you and you changed yourself? Dont be shamed show your identity so all can know wich material ur made up from.. May god give you some knowledge and peace.. follower of frustated party... haha
Bopanna: be matured, go through all the crime incidents and please dont try to climb for religious status. Mr Bopanna(its not your real name) might you are working and getting salary from religious of peace people's country) why cant you get out from KSA??? BE WELL MATURED BEFORE COMMENT.
@Bopanna. If you judge a BMW car by the driver of it, then your perception is not correct.
follower of piece is namo naresh !
The minute I read the heading I was thinking that this guy must be the
Follower of the \religion of peace\". As expected from you guys anyway"
Add new comment