India's daredevil woman biker Veenu Paliwal killed in accident

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

Mangaluru: The first-of-its kind Beach Zumba event organized by Veekshitha Arasa on January 26th at Panambur Beach, Mangaluru attracted huge crowd and entertained the masses. Thousands of people who visited the beach last Sunday evening witnessed and danced along with the talented Zumba instructors from Bengaluru and Mangaluru. The show lasted for almost two hours.

The programme was organized by Veekshitha Arasa in association with Panambur Beach Tourism with the cooperation of Panambur Police and sponsorship of AJ Hospital & Research Centre, APD Foundation and SS Arrangers & Caterers.

Panambur Beach Tourism CEO Yatish Baikampady, APD Foundation Trustee Abdullah Rehman and Santhosh Kumar from SS Arrangers and others flagged off the event by releasing saffron, white and green balloons (the colours of Indian tricolor) to mark the nation’s Republic Day. Panambur beach police officials too participated in the inauguration. Veekshitha Arasa’s husband Rohan Lobo, Veekshitha’s parents Bhaskar Arasa and Geetha B Arasa too joined in.

This was done with the message ‘Let the love for health and fitness fly high among the citizens much like the soaring spirit of patriotism’. Speaking on the occasion, Veekshitha said that it was her dream to conduct a Zumba event in the city. “This is my small attempt at promoting fitness among the citizens of Mangaluru. There should be more such events,” she said.

Meenal Dubey, Ashwitha Shetty, Vishal Rai, Aishwarya, Namratha Shekar, Shruthi Keerthiraj, Vinayak Acharya, Kavitha Manish and Urmi were some of the enthusiastic Zumba instructors who performed with Veekshitha.

RJ Nayana and Saravanan Govindaswamy compered the event.

Mangaluru, Apr 23: An elderly woman who was tested positive for COVID-19 in Dakshina Kannada district today breathed her last.

The deceased is a 77-year-old woman from Bantwal taluk. 

She is said to be a close relative of the Bantwal woman who died of COVID-19 on April 19.

She was shifted to govt Wenlock Hospital which is now converted into COVID-19 hospital on April 22 from a private hospital.

Her throat swabs were sent for testing. Health and family welfare department earlier today confirmed that she was tested positive for coronavirus.

Within hours she breathed her last without responding to any treatment. 

So far 17 corona positive cases have been confirmed in the district including two deaths. Most of them have returned home after recovering.