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Washington D.C., May 8: The prime time for brain development in a child's life is the first year, where the infant spends most of the time asleep. It is the time when neural connections form and sensory memories are encoded.

However, when sleep is disrupted, as occurs more often among children with autism, brain development may be affected, too.

New research led by the University of Washington finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

The study, which was published in the American Journal of Psychiatry, researchers report that in a sample of more than 400 taken of 6- to 12-month-old infants, those who were later diagnosed with autism were more likely to have had difficulty falling asleep.

It also states that this sleep difficulty was associated with altered growth trajectories in the hippocampus.

"The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children.

As many as 80 per cent of the children with autism spectrum disorder have sleep problems," said Annette Estes, director of the UW Autism Center and senior author of the study.

"In our clinical experience, parents have a lot of concerns about their children's sleep, and in our work on early autism intervention, we observed that sleep problems were holding children and families back," added Estes, who is also a UW professor of speech and hearing sciences.

"It could be that altered sleep is part-and-parcel of autism for some children. One clue is that behavioural interventions to improve sleep don't work for all children with autism, even when their parents are doing everything just right. This suggests that there may be a biological component to sleep problems for some children with autism," said Estes.

To consider links among sleep, brain development, and autism, researchers at the IBIS Network looked at MRI scans of 432 infants, surveyed parents about sleep patterns, and measured cognitive functioning using a standardized assessment.

At the outset of the study, infants were classified according to their risk for developing autism: Those who were at higher risk of developing autism -- about two-thirds of the study sample -- had an older sibling who had already been diagnosed.

Infant siblings of children with autism have a 20 per cent chance of developing autism spectrum disorder -- a much higher risk than children in the general population.

In the current study, 127 of the 432 infants were identified as "low risk" at the time the MRI scans were taken because they had no family history of autism.

They later evaluated all the participants at 24 months of age to determine whether they had developed autism. Of the roughly 300 children originally considered "high familial risk," 71 were diagnosed with autism spectrum disorder at that age.

Problems with sleep were more common among the infants later diagnosed with an autism spectrum disorder, as were larger hippocampi. No other subcortical brain structures were affected, including the amygdala, which is responsible for certain emotions and aspects of memory, or the thalamus, a signal transmitter from the spinal cord to the cerebral cortex.

The authors note that while parents reported more sleep difficulties among infants who developed autism compared to those who did not, the differences were very subtle and only observed when looking at group averages across hundreds of infants.

Sleep patterns in the first years of life change rapidly as infants transition from sleeping around the clock to a more adult-like sleep/wake cycle. Until further research is completed, Estes said, it is not possible to interpret challenges with sleep as an early sign of increased risk for autism.

Bengaluru, Apr 17: The Karnataka government has announced the purchase of an additional two lakh rapid test kits for COVID-19 detection at a task force meeting on Thursday.

Home Minister Basavaraj Bommai and other senior officials were present at the task force meeting chaired by Deputy Chief Minister Dr CN Ashwathnarayan.

The Chinese government has agreed to supply rapid test kits to an officially listed company, which will increase the number of tests once it arrives, Ashwathnarayan said.

Moreover, 250 kiosks will be set up in the state to collect saliva samples of a person with COVID-19 symptoms. Such kiosks will be launched one-by-one in taluks of the state.

Ashwathnarayan explained that this would increase the sample collection process and prevent the spread of disease.

Ashwathnarayan said the purchase of the required 25,000 RT-PCR kits was also approved.
He stated that COVID-19 patients should be treated at government-appointed hospitals. A separate coronavirus helpline will be made operational to address the queries of people, Ashwathnarayan said.

During Ramadan, it has been decided not to allow mass prayers, he said. And added that tracing of cases related to the Tablighi Jamaat meeting in Delhi has been completed in the state.

Bengaluru, Apr 6: The Covid-19 Task Force aims to conduct 80,000 throat swab and blood tests over the next three weeks here.

According to Task Force Nodal Officer C N Manjunath an order for one lakh anti-body test kits has been placed, and was expected to arrive on April 12.

"From January 20 to March 23, more than 1.2 lakh people arrived at international airports from abroad. Of these, we have kept 37,358 under observation. The Health officials and personnel in fever clinics and hospitals are being trained to conduct the tests. There is no necessity to obtain a clearance to test people with suspected infection. Only laboratories need to get permission to test their blood and throat swab samples."