Jarkiholi will quit Congress, he has sympathy towards Opposition: Poojary

Mangaluru, Mar 29: The second day of a total clampdown by Dakshin Kannada district had no impact as panic-stricken people rushed to buy essential commodities in markets in the City on Sunday without caring for Social distance to be maintained.

Since the crowd swell within minutes the police were forced to order the shops forcibly as otherwise, it might have led to spread of dreaded killer Coronavirus COVID-19.

The rise in Covid-19 cases in Dakshina Kannada and the neighbouring Kasargod district had forced the district administration to declare on total bandh on Saturday and Sunday but in vain.

Bengaluru, Mar 28: Sun Tsu, in 'The Art of War' speaks of a skilful general who can subdue his enemy without any fighting. This constitutes the ultimate triumph which is referred to as stratagem. Today, we would need one such when we are faced with the '21-day corona challenge' for India.
Nearly four weeks back, Dr Jyothsna Rao, Dr Gururaj Rao and I sat across the OPD in the afternoon at HCG Bengaluru discussing our ongoing cancer immunology research. While on this topic, we drifted into the discussion on the coronavirus. During this engaging discussion, we wondered the similarity of the enigma between the virus and cancer. I paused to ask Dr Jyothsna and Dr Guru - how we wish we could do something against this virus.
Dr Jyothsna is a PhD from NCBS and had worked under Dr Ralph Steinman, physician and researcher from Rockefeller University, who won the Nobel Prize for his discovery of the dendritic cell and its role in adaptive immunity in 2011. Dr Gururaj is a molecular and cell biologist who did his PhD at the Chapel Hill, University of North Carolina and is the Director of iCrest.
Jyothsna while hearing our perplexing conversation on the covid intervened, "Yes, surely. I think we should take a break from cancer and focus on the innate and adaptive immunity role in COVID-19."
Thus began this sincere attempt to relook the human immune system from the eyes of the COVID-19.
We have 10 types of immune cells at the least which are widely dispersed in millions across the body. When our body is invaded by a foreign organism (bacteria, fungi or virus), these cells work with each other to destroy the invader.
Now, the question is - how do the immune cells talk to each other? They use small-molecule substances called cytokines (cyto means cells; kine means movement). There are many cytokines that are involved in work on the immune system. The most relevant for viruses are interferons.
Interferons (IFN) as the name reflects have an ability to interfere with the viral activity and stop their multiplication. These specialised signal proteins are released by our cells in response to a viral attack to forewarn other cells. They help build the antiviral proteins within the cells to kill the virus as it tries to invade the new cells.
Historically, interferons are a group of cytokines known to be potent antiviral agents against viruses and a hallmark cytokine induced by the host upon viral infections. Interferons possess unique immunoregulatory activities and are signature cytokines released by (TH1) T immune cells, which are crucial in viral infections.
As the outbreak of COVID-19 grapples us, an urgent need for finding strategies to combat the virus is growing. Coronaviruses (CoVs) are a group of RNA viruses. In patients infected with coronavirus, it was indicated that the activation of the IFN does not occur until 48 hours post-infection. Thus the delayed IFN-related antiviral response by the healthy cells leads to coronavirus evade the immune response.
Numerous studies have presented the success in defeating CoVs by the direct administration of IFNs. In a combination as a concoction, it was shown to synergistically inhibit the virus replication in vitro.
Moreover, it is understood that the earlier induction of IFNs in children although they have a less developed immune system could be the reason behind the children being least affected.
The key to success in reducing the disease fatality might be the stimulation of the immune responses to trigger IFN production at the very early stages of the disease, which might be done through the administration of IFN. Despite the evidence for the efficacy of IFNs in treating CoV-induced infections, the proper dosing and ideal timing for such interventions needs to be verified in clinical trials.
For the later stages of the diseases in advance stages where patients are on ventilator and have developed respiratory distress, we propose to utilise the mesenchymal cells derived from donor bone marrow that have been known to treat acute respiratory syndrome. Mesenchymal cells are known to possess anti-inflammatory activity and thus used often in autoimmune diseases.
With this scientific background, we have activated T cells from healthy donors, in a cGMP facility at iCrest - HCG hospital with an enriched cocktail of cytokines rich in Interferons. Injections of this cocktail we believe will result in a surge of cytokines in the body of the infected person and will boost his ability to fight the virus in the early phases. We are in the initial phases of this study and hope to be ready in the coming weeks with meaningful data on its potential utility.
Currently, it awaits government approvals (Union and state) and we have applied to central drugs authority for their initial evaluation and further directions.
As my Guru often expounded the philosophy of 'Seva' - the goal of education is knowledge, the end goal of knowledge is service. In this attempt to serve our fellow humans at this brink of unprecedented crisis, medical fraternity stands with you and promises to do our best for your safety.
We assure to exhaust every bit of our spirit in this fight against coronavirus. We have lost the sight of shores and travelled thus far, but that is the mandatory first step to cross the ocean. Are we going to succeed in this battle, is something only time will answer. 

On Friday, February 7, 2020 Tulu Koota Kuwait under the leadership of Dynamic President Ramesh S Bhandary and coordination of Sports Secretary Roshan Quadras  held its annual picnic at Mishref Garden, Kuwait.  Although slight drizzling on the   previous night had caused great concern amongst committee members , yet the  windy and dusty weather did not lessen the enthusiasm and excitement of Tulu Koota Kuwait members.  Over 1000 members enjoyed the fun filled day.

MC of the occasion Mr. Manoj Shetty & Ms. Priya Devadiga welcomed the audience and Chief guests for the event Dr Jeshna Rajan- Badr Al Samaa Clinic, Dr. S.M.Hyther Ali- Chairman of TVS Hyder Group, Mr. John Simon- Group Manager for Corporate Sales and Event Marketing ,  Al Mulla Exchange, Mr Pradeep, owner of Geetherb medicine and Mr. Lokesh & Team from NH Assets.  The program kicked off with Kuwait & Indian National anthem. The guests in their address to audience, praised Tulu Koota Kuwait unwavering efforts to unite people through language, and also the solid philanthropy and charity work being carried by the association was applauded. The presidents  of different South Canara  association in Kuwait were also amongst invited dignitaries for the event, and were welcomed with flower bouquet. This was followed by the release of “ Tulu Nada Jathre flyer”.

Tulu Koota Kuwait President, Ramesh S Bhandary in his speech welcomed the dignitaries and emphasized the significance of the annual picnic gathering. He further elaborated on the innovative concept of “Tulunada Jathre ” being initiated this year, and requested fervent support and participation from all members in  this wonderful program scheduled to be held on Friday,  March 27, 2020 at Indian Central School Indoor Ground Abbasiya. 

As part of days celebration TKK’s Flag hosting  was done  by President , Ramesh Bhandary. “Go Green Global concept” by Tulu Koota members   was the highlight of the inaugural ceremony.  This act was directed by talented committee member Mr. Suresh Salian.

The act beautifully conveyed the message of sustainability, and climate change and raised awareness on how to fight it, how to live green.  The traditional inaugural of the sports event was done by breaking of coconut by Sports Secretary Mr. Roshan Quadras.  TKK First Lady Mrs Anitha Ramesh Bhandary led the sports march holding the traditional torch followed by the  Go Green Global team holding different country flags with plant pots, followed by President, committee members and Sponsors of TKK. The president officially inaugurated the Sports Event by officially lighting the Sports Lamp.

After the inauguration ceremony, the members and kids actively participated in day long sports games and activities meticulously planned out by the Sports committee  for different age groups.  Passing the parcel, Veggies collection, ball bucket, veg shopping , macroni race, hockey, kutti donne, sack race, lagori,  breaking the pot , tyre race, slow cycling, water ballon race, musical chair , kabbadi, volley ball, throw  ball , tug of war, housie housie, kept the members and their families  engaged and entertained. The winners for the competitions were awarded with trophies towards the end of the exciting day.

Delicious and authentic Mangalorean lunch for the event was served by Oriental Restaurant Kuwait.  Sounds and lights support for the event was provided by Anand, while the beautiful moments were captured in camera by Mr.Blen Dsouza and Mr.Rajesh Devadiga

Tulu Koota Kuwait takes this opportunity to thank its committee members, members and volunteers for their dedicated efforts and team spirit and active participation that eventually lead to the huge success of Family Picnic 2020. The Event Sponsors were Al Ahleia Insurance Company SAKP, Al Mulla Exchange, Khain Properties Udupi, Badr Al-Samaa Clinic, TVS Hyder Group and Geetherb.