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Beijing/Zurich, Mar 4: China has approved the use of Swiss drugmaker Roche's anti-inflammation drug Actemra for patients who develop severe complications from the coronavirus as it urgently hunts for new ways to combat the deadly infection that is spreading worldwide.

China is hoping that some older drugs could stop severe cytokine release syndrome (CRS), or cytokine storms, an overreaction of the immune system which is considered a major factor behind catastrophic organ failure and death in some coronavirus patients.

Actemra, a biologic drug approved in 2010 in the United States for rheumatoid arthritis (RA), inhibits high Interleukin 6 (IL-6) protein levels that drive some inflammatory diseases.

China's National Health Commission said in treatment guidelines published online on Wednesday that Actemra can now be used to treat coronavirus patients with serious lung damage and high IL-6 levels.

Separately, researchers in the country are testing Actemra, known generically as tocilizumab, in a clinical trial expected to include 188 coronavirus patients and running until May 10.

Roche, which donated 14 million yuan ($2.02 million) worth of Actemra during February, said the trial was initiated independently by a third party with the aim of exploring the efficacy and safety of the drug in coronavirus patients with CRS.

It added that there was currently no published clinical trial data on the drug's safety or efficacy against the virus.

More than 3,000 people have died and 93,000 have been infected by the novel coronavirus thought to have originated in Wuhan, China, before spreading to around 90 countries including the United States, Italy, Switzerland, France and Germany.

The Swiss company, for which China is its No. 2 market behind the United States, also makes diagnostic gear to detect the coronavirus.

Since Actemra's approval a decade ago, it has become a go-to drug against other inflammatory conditions, including cytokine storms in cancer patients receiving cell therapies from Novartis and Gilead Sciences.

In 2012 it helped save the life of a young U.S. girl, the first child to be treated for leukaemia with Novatis' Kymriah, from a post-treatment rush of IL-6.

Priced at between $20-30,000 annually for RA according to SSR Health, Roche's medicine is also used for rare juvenile arthritis and giant cell arteritis, or inflammation of the blood vessels.

New Delhi, May 17: Spelling out the government’s fourth tranche of initiatives towards achieving Prime Minister Narendra Modi’s vision of ‘Atmanirbhar Bharat’, Union Finance Minister Nirmala Sitharaman on Saturday announced significant structural reforms in eight sectors of the economy — coal, minerals, defense production, aviation, power distribution in Union territories, space and atomic energy.

Addressing her fourth and the second-last press conference, Sitharaman said crucial sectors such as coal production and exploration, defence production and space would see an increased participation from private entities.

Coal sector:

In the realm of coal exploration, the government has decided to liberalise the entry norms for private entities, which would mean that any interested party could bid for a coal block and sell it in the open market. The minister said that the government would do away with all the eligibility conditions at the time of bidding for a coal block, except requiring an “upfront payment with a ceiling.”

Nearly 50 coal blocks would be offered to private players immediately, revealed Sitharaman.

She further said that Rs 50,000 crore would be spent by Centre in creating ‘coal evacuation’ infrastructure, which would expedite the transport of mined product to the destination.

Defence sector:

In defence production, Sitharaman revealed that the government would raise the foreign direct investment (FDI) limit in the sector from current 49 per cent to 74 per cent. Further, the government would also work towards corporatising the ordnance factory boards. “Corporatising doesn’t amount to privatization,” added Sitharaman.

In a bid to boost indigenous production of defence products and gave an impetus to Make in India, Sitharaman said that the government was in a process of notifying a list of weapons/platforms for an import ban with year-wise timelines.

These decisions would also help in reducing huge import bills, the finance minister said.

Privatisation of electricity:

In another announcement that could have an effect on electricity charges in the union territories, Union Finance Minister Nirmala Sitharaman announced on Saturday that power departments and utilities in all the centrally administered territories would be privatised.

Sitharaman said that the proposed move would lead to better service to consumers and improvement in operational and financial efficiency in distribution.

The finance minister said that decision was guided by 'sub-optimal' utilisation of performance of power distribution and supply'.

She said that the move to that effect would provide a model for emulation by other utilities across the country, in what could be an indicator of what's in the pipeline for utilities in other states as well.

Sitharaman said that the privation reform was in line with the tariff policy reforms and would help in enhancing consumer rights, promote industry and improve the overall sustainability of the sector.

Space sector:

Sitharaman also announced the opening up of the space exploration sector for private players. Till date, the government-run Indian Space Research Organisation (ISRO) has held a monopoly on all activities concerning space exploration and satellite launches.

The Indian private sector will be a co-traveller in India's space sector journey, said Sitharaman, while announcing a series of structural reforms in eight crucial areas of the economy. The Union Finance Minister was addressing her fourth press conference in as many days, as a follow-up towards realising Prime Minister Narendra Modi's vision of 'atmanirbhar Bharat', which was spelled out in his video address on May 12.

Sitharaman said that the reforms in the space sector will provide a level-playing field for private companies in satellite launches and space-based services.

She said that the private sector would be allowed to use ISRO facilities and other assets to improve their capacities. Stating that the government would provide predictable policy and regulatory environment to private players, Sitharaman also disclosed that future projects for planetary exploration and outer space travel among others would be opened up for private entities.

Thiruvananthapuram, Jan 10: Eminent Carnatic vocalist and playback singer K J Yesudas, who has enthralled music aficionados across the world with his profound and mellifluous voice for the last six decades, turned 80 on Friday.

People from various walks of life, including Prime Minister Narendra Modi, Kerala Chief Minister Pinarayi Vijayan and luminaries of music and film world besides socio-cultural personalities, wished the legendary singer, popularly called as 'gana gandharvan' (the celestial singer) by his fans, on his birthday.

Regional newspapers came out with special pages and television channels with exclusive programmes as a tribute to the singer, who has recorded over 80,000 songs in various genres in almost all languages of India including about 25,000 film songs, Carnatic bhajans and devotional songs.

Besides Indian languages like Malayalam, Tamil, Telugu, Hindi, Kannada, Bengali, Odia, his voice gave life to songs in Arabic, English, Latin, and Russian during a career spanning over six decades.

Yesudas, whom the country had honoured with Padma Vibhushan in 2017, is the recipient of eight national awards, 25 Kerala state awards, five state awards of Tamil Nadu and four of Andhra Pradesh.

"On the special occasion of his 80th birthday, greetings to the versatile K J Yesudas Ji. His melodious music and soulful renditions have made him popular across all age groups. He has made valuable contributions to Indian culture. Wishing him a long and healthy life," Modi tweeted.

The Left veteran also shared a photo of the veteran singer along with the tweet.

Meanwhile, Yesudas this morning visited the Mookambika Temple at Kollur in Udupi district of Karnataka along with his family, a practice he has been following for the last four decades.

Draped in the traditional Kerala style kasavu mundu and shawl, 'dasettan', as he is known among his hardcore fans cutting across ages, Yesudas offered prayers along with his wife Prabha and sons and performed special poojas at the Goddess Saraswathi temple.

Hundreds of music buffs gathered at the shrine to wish the octogenarian singer.

Considered as one of the best playback singers in the country, Yesudas had begun his music career in the tinsel town with the Malayalam song "Jathi bhedam matha dwesham" in the year 1961 and sang in Tamil, Telugu and Kannada films among other languages.

Yesudas's foray into Bollywood saw him recording various memorable hits, including "Jab Deep Jale Aana" and "Gori Tera Gaon Bada Pyara".